MMN and Novelty P3 in Coma and Other Altered States of Consciousness: A Review.

Abstract : In recent decades, there has been a growing interest in the assessment of patients in altered states of consciousness. There is a need for accurate and early prediction of awakening and recovery from coma. Neurophysiological assessment of coma was once restricted to brainstem auditory and primary cortex somatosensory evoked potentials elicited in the 30 ms range, which have both shown good predictive value for poor coma outcome only. In this paper, we review how passive auditory oddball paradigms including deviant and novel sounds have proved their efficiency in assessing brain function at a higher level, without requiring the patient's active involvement, thus providing an enhanced tool for the prediction of coma outcome. The presence of an MMN in response to deviant stimuli highlights preserved automatic sensory memory processes. Recorded during coma, MMN has shown high specificity as a predictor of recovery of consciousness. The presence of a novelty P3 in response to the subject's own first name presented as a novel (rare) stimulus has shown a good correlation with coma awakening. There is now a growing interest in the search for markers of consciousness, if there are any, in unresponsive patients (chronic vegetative or minimally conscious states). We discuss the different ERP patterns observed in these patients. The presence of novelty P3, including parietal components and possibly followed by a late parietal positivity, raises the possibility that some awareness processes are at work in these unresponsive patients.
Type de document :
Article dans une revue
Brain Topography, Springer Verlag, 2014, 27 (4), pp.467-79. 〈10.1007/s10548-013-0335-5〉
Liste complète des métadonnées

Littérature citée [60 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00914320
Contributeur : Dominique Morlet <>
Soumis le : jeudi 5 décembre 2013 - 11:48:41
Dernière modification le : jeudi 15 mars 2018 - 10:14:01
Document(s) archivé(s) le : samedi 8 avril 2017 - 04:33:48

Fichiers

Ms_BTOP_D_13_00088R1_12_nov_13...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Dominique Morlet, Catherine Fischer. MMN and Novelty P3 in Coma and Other Altered States of Consciousness: A Review.. Brain Topography, Springer Verlag, 2014, 27 (4), pp.467-79. 〈10.1007/s10548-013-0335-5〉. 〈inserm-00914320〉

Partager

Métriques

Consultations de la notice

120

Téléchargements de fichiers

412