Primary prophylaxis of disseminated histoplasmosis in HIV patients in French Guiana: arguments for cost effectiveness.

Abstract : Histoplasmosis is the first cause of acquired immunodeficiency syndrome (AIDS) and AIDS-related deaths in French Guiana. Cohort data were used to determine whether primary prophylaxis with 100 mg itraconazole for patients with CD4 counts < 150/mm(3) was cost-effective with different scenarios. For a scenario where 12% of patients died, 60% were aware of their human immunodeficiency virus (HIV) infection and adherence was only 50%, primary prophylaxis would prevent 1 death and 9 cases of histoplasmosis for a cost of 36,792 Euros per averted death, 1,533 per life-year saved, 4,415 Euros per averted case, when only counting the costs of itraconazole prophylaxis. Taking into account the total costs of hospitalization showed that primary prophylaxis would allow a savings of 185,178 Euros per year. Even in a scenario of low adherence, primary prophylaxis would be cost-effective in French Guiana, and presumably in the rest of the Guianas and the Amazon.
Type de document :
Article dans une revue
American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 89 (6), pp.1195-8. 〈10.4269/ajtmh.13-0082〉
Liste complète des métadonnées

Littérature citée [3 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00913886
Contributeur : Antoine Adenis <>
Soumis le : vendredi 3 octobre 2014 - 10:51:45
Dernière modification le : mercredi 7 mars 2018 - 01:13:21
Document(s) archivé(s) le : dimanche 4 janvier 2015 - 10:12:23

Fichiers

2013_Nacher_-_Primary_prophyla...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Mathieu Nacher, Antoine Adenis, Celia Basurko, Vincent Vantilcke, Denis Blanchet, et al.. Primary prophylaxis of disseminated histoplasmosis in HIV patients in French Guiana: arguments for cost effectiveness.. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2013, 89 (6), pp.1195-8. 〈10.4269/ajtmh.13-0082〉. 〈inserm-00913886〉

Partager

Métriques

Consultations de la notice

695

Téléchargements de fichiers

126