M. Gilead and P. Companies, JFT participated to scientific committee of epidemiological studies organized by Astellas and Merck companies. MC has received research grants from Pfizer. JPG received lecture fees from Astellas, Gilead, Merck and Pfizer, and participated in scientific committee of epidemiological studies organized by Astellas and Merck. VJ is a member of Astellas scientific committee, received lecture fees from Tibotec and BMS and received research grants from Biocodex and Sanofi, MW received lectures fees from Astellas

M. , V. Ea, and M. , Authors' contributions JFT drafted the manuscript and contributed to the design of the study JPG contributed to the design of the study and helped to draft the manuscript. AV, JFT and VJ prepared the statistical analysis and helped to draft the manuscript, All authors read and approved the final manuscript

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