Peroxisomes, lipid metabolism 18 and lipotoxicity 20 Characterization of the gene encoding human peroxisomal 3-oxoacyl-CoA thiolase 21 (ACAA) No large DNA rearrangement in a thiolase-deficient patient, Biochim. Biophys. Acta Biochim. Biophys. Acta Am. J. Hum. Genet, vol.16, issue.704, pp.17-272, 1991. ,
Molecular cloning, gene structure and expression profile of two mouse 29 peroxisomal 3-ketoacyl-CoA thiolase genes, BMC Biochem, vol.55, issue.3, p.30, 2004. ,
Cloning and sequence determination of cDNA 34 encoding a second rat liver peroxisomal 3-ketoacyl-CoA thiolase Comparison 1 of the stability and substrate specificity of purified peroxisomal 3-oxoacyl-CoA thiolases A 2 and B from rat liver, Wirtz, R.J. Wanders, N. Maeda, G. Assmann, Defective peroxisomal 5 catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier, pp.4600-4606, 1990. ,
Seedorf, 8 Identification of the newly discovered 58 kDa peroxisomal thiolase SCPx as the main 9 thiolase involved in both pristanic acid and trihydroxycholestanoic acid oxidation: 10 implications for peroxisomal beta-oxidation disorders, Genes Dev. J Inherit Metab Dis, vol.1210, issue.12, pp.1189-1201, 1998. ,
G939-951. 15 [11] I Peroxisomal cholesterol 16 biosynthesis and Smith-Lemli-Opitz syndrome 19 Characterization of peroxisomal 3-hydroxy-3-methylglutaryl coenzyme A reductase in UT2 20 cells: sterol biosynthesis, phosphorylation, degradation, and statin inhibition Role of peroxisomes in 23 isoprenoid biosynthesis, Clemencet, N. Latruffe, V. Nicolas-Frances, pp.205-209, 1999. ,
The Peroxisomal 3-keto-acyl-CoA thiolase B Gene Expression Is under the Dual 30 Control of PPARalpha and HNF4alpha in the Liver Peroxisome proliferator-activated receptor alpha 32 target genes Peroxisome proliferator- 34 activated receptor alpha target genes, PPAR Res Cell. Mol. Life Sci. PPAR Res, vol.16, issue.33, pp.31-393, 2004. ,
The Interleukin-1 receptor antagonist is a direct 37 target gene of PPARalpha in liver, J. Hepatol, vol.46, issue.38, pp.869-877, 2007. ,
PPARalpha governs glycerol 40 metabolism, J. Clin. Invest, vol.114, pp.94-103, 2004. ,
The 45 PPARalpha-leukotriene B4 pathway to inflammation control Nuclear control of the inflammatory response in mammals 47 by peroxisome proliferator-activated receptors, Physiological and Nutritional 49 Roles of PPAR across Species, pp.1145-1157, 1996. ,
Modulation of the hepatic fatty acid 2 pool in peroxisomal 3-ketoacyl-CoA thiolase B-null mice exposed to the selective 3 ,
Thorens, Peroxisomal and microsomal lipid 14 pathways associated with resistance to hepatic steatosis and reduced pro-inflammatory state, 15 Induction of peroxisomal lipid metabolism in mice fed a 18 high-fat diet, Okano, 17 S. Nakashima, N. Shimozawa, pp.31011-31023, 2010. ,
Constitutive androstane receptor activation 24 stimulates faecal bile acid excretion and reverse cholesterol transport in mice A comparison of three methods of glycogen 27 measurement in tissues, J Hepatol Anal Biochem, vol.55, issue.28, pp.25-154, 1974. ,
Nuclear localization of a new c-cbl related protein, CARP 90, during 30 in vivo thymic apoptosis in mice, Cell. Death Differ, vol.6, pp.689-697, 1999. ,
33 Coordinate induction of PPARalpha and SREBP2 in multifunctional protein 2 deficient 34 mice Normal 36 growth and development in the absence of hepatic insulin-like growth factor I, Proc. Natl, pp.35-37, 2008. ,
Liver-specific igf-1 gene deletion leads to muscle 40 insulin insensitivity, Diabetes, vol.50, pp.1110-1118, 2001. ,
Low serum levels of free and total insulin-like growth factor I (IGF-I) in patients 43 with anorexia nervosa are not associated with increased IGF-binding protein-3 proteolysis, p.44 ,
1346-1350 46 Dissociated insulinotropic sensitivity to glucose and carbachol in high-fat diet-induced 47 insulin resistance in C57BL/6J mice, Clin. Endocrinol. Metab. Metabolism, vol.8438, issue.48, pp.45-97, 1997. ,
The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity, J Biol Chem, vol.281, issue.1 2 3, pp.934-944, 2006. ,
Inflammasome is a central player 5 in the induction of obesity and insulin resistance, Proc Natl Acad Sci U S A, vol.108, issue.740 8, pp.15324-15329, 2011. ,
Obesity and insulin resistance Adipogenesis and 15 insulin sensitivity in obesity are regulated by retinoid-related orphan receptor gamma, 16 EMBO molecular medicine 3 (2011) 637-651 19 Separation of human adipocytes by size: hypertrophic fat cells display distinct gene 20 expression HDL-C concentration is related to markers of absorption and of 23 cholesterol synthesis: Study in subjects with low vs, Adipose tissue dysfunction signals progression of hepatic 9 steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice, pp.3181-3191, 2000. ,
Peroxisome deficiency-induced ER stress 27 and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice, p.30 ,
Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout 35 mouse model Central role of peroxisomes in isoprenoid 37 biosynthesis A comprehensive 39 machine-readable view of the mammalian cholesterol biosynthesis pathway Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in 43 humans, Localization of the pre-squalene segment of the isoprenoid 31 biosynthetic pathway in mammalian peroxisomes Angptl4 upregulates cholesterol synthesis 46 in liver via inhibition of LPL-and HL-dependent hepatic cholesterol uptake, pp.273-305, 1988. ,
Knockout of mouse Cyp3a gene enhances 2 synthesis of cholesterol and bile acid in the liver, J Lipid Res, 2013. ,
Isotopomer spectral analysis of intermediates of cholesterol 5 synthesis in human subjects and hepatic cells Relative contributions by liver and intestine to 8 individual plasma apolipoproteins in the rat Quantitative proteomic comparison of mouse 10 peroxisomes from liver and kidney, Am J Physiol Endocrinol Metab J Biol Chem Proteomics, vol.282, issue.756, pp.7316-7322, 1222. ,
Circulating levels of IGF-1 directly 13 regulate bone growth and density Steatohepatitis, 15 spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty 16 acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural 17 ligand metabolism, J Clin Invest J. Biol. Chem, vol.110, issue.18, pp.771-781, 1998. ,
the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but 21 also of very long chain fatty acids Defect in 23 peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines 24 the severity of hepatic steatosis in response to fasting, J. Biol. Chem. J Biol Chem, vol.20, issue.275, pp.16329-16336, 1926. ,
Inhibition of mitochondrial fatty acid oxidation in vivo only slightly suppresses 28 gluconeogenesis but enhances clearance of glucose in mice 1032- 29 1042 Role of the low density lipoprotein 31 receptor in the flux of cholesterol through the plasma and across the tissues of the mouse, Hepatology J 32 Clin Invest, vol.4762, issue.33, pp.1124-1132, 1995. ,
Lathosterolosis: an 35 inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase 36 deficiency Sources of cholesterol for kidney and nerve during 38 development Apolipoprotein E 40 synthesis in human kidney, adrenal gland, and liver Substrate 43 specificities of 3-oxoacyl-CoA thiolase A and sterol carrier protein 2/3-oxoacyl-CoA 44 thiolase purified from normal rat liver peroxisomes Sterol carrier protein 2/3-oxoacyl-CoA 45 thiolase is involved in the metabolism of 2-methyl-branched fatty acids and bile acid 46 intermediates, Hum. Mol. Genet. J Lipid Res Proc Natl Acad Sci U S A J Biol Chem, vol.12120, issue.27266, pp.1631-1641, 1983. ,
Peroxisomal and mitochondrial oxidation of fatty acids in the ,