D. Hardie, F. Ross, and S. Hawley, AMPK: a nutrient and energy sensor that maintains energy homeostasis, Nature Reviews Molecular Cell Biology, vol.26, issue.4, pp.251-262
DOI : 10.1038/nrm3311

G. Steinberg and B. Kemp, AMPK in Health and Disease, Physiological Reviews, vol.89, issue.3, pp.1025-1078, 2009.
DOI : 10.1152/physrev.00011.2008

D. Hardie, Signal transduction: How cells sense energy, Nature, vol.107, issue.7342, pp.472176-177, 2011.
DOI : 10.1038/472176a

M. Bland and M. Birnbaum, ADaPting to Energetic Stress, Science, vol.265, issue.1, pp.1387-1388, 2011.
DOI : 10.1242/jeb.00426

A. Woods, S. Johnstone, K. Dickerson, F. Leiper, L. Fryer et al., LKB1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade, Current Biology, vol.13, issue.22, pp.1-132004, 2003.
DOI : 10.1016/j.cub.2003.10.031

URL : https://hal.archives-ouvertes.fr/inserm-00390855

B. Xiao, M. Sanders, E. Underwood, R. Heath, F. Mayer et al., Structure of mammalian AMPK and its regulation by ADP, Nature, vol.50, issue.7342, pp.472230-233, 2011.
DOI : 10.1038/nature09932

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078618

O. Akhilljs and P. Lingn, AMPK is a direct adenylate charge-regulated protein kinase, Science, vol.332, issue.6036, pp.1433-1435, 2011.

D. Carling, The AMP-activated protein kinase cascade ??? a unifying system for energy control, Trends in Biochemical Sciences, vol.29, issue.1, pp.18-24, 2004.
DOI : 10.1016/j.tibs.2003.11.005

D. Hardie, AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy, Nature Reviews Molecular Cell Biology, vol.367, issue.10, pp.774-785, 2007.
DOI : 10.1038/nrm2249

D. Hardie and D. Carling, The AMP-Activated Protein Kinase. Fuel Gauge of the Mammalian Cell?, European Journal of Biochemistry, vol.12, issue.2, pp.259-273, 1997.
DOI : 10.1006/scel.1994.1048

D. Hardie, AMP-activated protein kinase: the guardian of cardiac energy status, Journal of Clinical Investigation, vol.114, issue.4, pp.465-468, 2004.
DOI : 10.1172/JCI200422683

K. Hallows, P. Mount, N. Pastor-soler, and D. Power, Role of the energy sensor AMP-activated protein kinase in renal physiology and disease, AJP: Renal Physiology, vol.298, issue.5
DOI : 10.1152/ajprenal.00005.2010

L. Hue, C. Beauloye, L. Bertrand, S. Horman, U. Krause et al., New targets of AMP-activated protein kinase, Biochemical Society Transactions, vol.31, issue.1, pp.31213-215, 2003.
DOI : 10.1042/bst0310213

D. Hardie, D. Carling, and M. Carlson, THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?, Annual Review of Biochemistry, vol.67, issue.1, pp.821-855, 1998.
DOI : 10.1146/annurev.biochem.67.1.821

D. Hardie and D. Pan, Regulation of fatty acid synthesis and oxidation by the AMP-activated protein kinase, Biochemical Society Transactions, vol.30, issue.6, pp.1064-1070, 2002.
DOI : 10.1042/bst0301064

N. Hay and N. Sonenberg, Upstream and downstream of mTOR, Genes & Development, vol.18, issue.16, pp.1926-1945, 2004.
DOI : 10.1101/gad.1212704

D. Gwinn, D. Shackelford, D. Egan, M. Mihaylova, A. Mery et al., AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint, Molecular Cell, vol.30, issue.2, pp.214-226, 2008.
DOI : 10.1016/j.molcel.2008.03.003

W. Lieberthal, L. Zhang, V. Patel, and J. Levine, AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation, AJP: Renal Physiology, vol.301, issue.6, pp.1177-1192, 2011.
DOI : 10.1152/ajprenal.00034.2011

B. Viollet, F. Andreelli, S. Jorgensen, C. Perrin, A. Geloen et al., The AMP-activated protein kinase ??2 catalytic subunit controls whole-body insulin sensitivity, Journal of Clinical Investigation, vol.111, issue.1, pp.91-98, 2003.
DOI : 10.1172/JCI16567

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151837

S. Jorgensen, B. Viollet, F. Andreelli, C. Frosig, J. Birk et al., Knockout of the ??2 but Not ??1 5'-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-??-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle, Journal of Biological Chemistry, vol.279, issue.2, pp.1070-1079, 2004.
DOI : 10.1074/jbc.M306205200

V. Kroshian, A. Sheridan, and W. Lieberthal, Functional and cytoskeletal changes induced by sublethal injury in proximal tubular epithelial cells, Am J Physiol, vol.266, issue.1 2, pp.21-30, 1994.

W. Lieberthal, S. Menza, and J. Levine, Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cells

D. Sinha, Z. Wang, K. Ruchalski, J. Levine, S. Krishnan et al., Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors, AJP: Renal Physiology, vol.288, issue.4, pp.703-713, 2005.
DOI : 10.1152/ajprenal.00189.2004

A. Gruzman, G. Babai, and S. Sasson, Adenosine Monophosphate-Activated Protein Kinase (AMPK) as a New Target for Antidiabetic Drugs: A Review on Metabolic, Pharmacological and Chemical Considerations, The Review of Diabetic Studies, vol.6, issue.1, pp.13-36, 2009.
DOI : 10.1900/RDS.2009.6.13

H. Mori, K. Inoki, K. Masutani, Y. Wakabayashi, K. Komai et al., The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential, Biochemical and Biophysical Research Communications, vol.384, issue.4, pp.471-475, 2009.
DOI : 10.1016/j.bbrc.2009.04.136

Z. Luo, A. Saha, X. Xiang, and N. Ruderman, AMPK, the metabolic syndrome and cancer, Trends in Pharmacological Sciences, vol.26, issue.2, pp.69-76, 2005.
DOI : 10.1016/j.tips.2004.12.011

B. Kola, M. Boscaro, G. Rutter, A. Grossman, and M. Korbonits, Expanding role of AMPK in endocrinology, Trends in Endocrinology & Metabolism, vol.17, issue.5, pp.205-215, 2006.
DOI : 10.1016/j.tem.2006.05.006

N. Musi and L. Goodyear, Targeting the AMP-Activated Protein Kinase for the Treatment of Type 2 Diabetes, Current Drug Target - Immune, Endocrine & Metabolic Disorders, vol.2, issue.2, pp.119-127, 2002.
DOI : 10.2174/1568005310202020119

K. Kato, T. Ogura, A. Kishimoto, Y. Minegishi, N. Nakajima et al., Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation, Oncogene, vol.21, issue.39, pp.6082-6090, 2002.
DOI : 10.1038/sj.onc.1205737

M. Arad, C. Seidman, and J. Seidman, AMP-Activated Protein Kinase in the Heart: Role During Health and Disease, Circulation Research, vol.100, issue.4, pp.474-488, 2007.
DOI : 10.1161/01.RES.0000258446.23525.37

R. Russell, J. Li, D. Coven, M. Pypaert, C. Zechner et al., AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury, Journal of Clinical Investigation, vol.114, issue.4, pp.495-503, 2004.
DOI : 10.1172/JCI19297

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC503766

N. Spector, Y. Yarden, B. Smith, L. Lyass, P. Trusk et al., Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells, Proceedings of the National Academy of Sciences, vol.83, issue.1, pp.10410607-10612, 2007.
DOI : 10.1139/y04-107

R. Shibata, K. Sato, D. Pimentel, Y. Takemura, S. Kihara et al., Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2???dependent mechanisms, Nature Medicine, vol.101, issue.10, pp.111096-1103, 2005.
DOI : 10.1074/jbc.M300643200

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828682

K. Terai, Y. Hiramoto, M. Masaki, S. Sugiyama, T. Kuroda et al., AMPactivated protein kinase protects cardiomyocytes against hypoxic injury through attenuation of endoplasmic reticulum stress, Mol Cell Biol, issue.21, pp.259554-9575, 2005.

C. Peralta, R. Bartrons, A. Serafin, C. Blazquez, M. Guzman et al., Adenosine monophosphate-activated protein kinase mediates the protective effects of ischemic preconditioning on hepatic ischemiareperfusion injury in the rat, Hepatology, issue.6, pp.341164-1173, 2001.

J. Li, Z. Zeng, B. Viollet, G. Ronnett, and L. Mccullough, Neuroprotective Effects of Adenosine Monophosphate- Activated Protein Kinase Inhibition and Gene Deletion in Stroke, Stroke, vol.38, issue.11, pp.2992-2999, 2007.
DOI : 10.1161/STROKEAHA.107.490904

L. Mccullough, Z. Zeng, H. Li, L. Landree, J. Mcfadden et al., Pharmacological Inhibition of AMP-activated Protein Kinase Provides Neuroprotection in Stroke, Journal of Biological Chemistry, vol.280, issue.21, pp.20493-20502, 2005.
DOI : 10.1074/jbc.M409985200

C. Cao, S. Lu, R. Kivlin, B. Wallin, E. Card et al., AMP-activated protein kinase contributes to UV-and H2O2-induced apoptosis in human skin keratinocytes, J Biol Chem, issue.43, pp.28328897-28908, 2008.
DOI : 10.1074/jbc.m804144200

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570892

R. Memmott, J. Gills, M. Hollingshead, M. Powers, Z. Chen et al., Phosphatidylinositol Ether Lipid Analogues Induce AMP-Activated Protein Kinase Dependent Death in LKB1-Mutant Non Small Cell Lung Cancer Cells, Cancer Research, vol.68, issue.2, pp.580-588, 2008.
DOI : 10.1158/0008-5472.CAN-07-3091

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558831

R. Okoshi, T. Ozaki, H. Yamamoto, K. Ando, N. Koida et al., Activation of AMP-activated Protein Kinase Induces p53-dependent Apoptotic Cell Death in Response to Energetic Stress, Journal of Biological Chemistry, vol.283, issue.7, pp.2833979-3987, 2008.
DOI : 10.1074/jbc.M705232200

M. Shaw, W. Gurr, R. Mccrimmon, D. Schorderet, and R. Sherwin, AMP- activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells, J Cell Mol Med, vol.5, issue.112, pp.286-298, 2007.
DOI : 10.1111/j.1582-4934.2007.00023.x

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3822827

A. Tzatsos and P. Tsichlis, Energy Depletion Inhibits Phosphatidylinositol 3-Kinase/Akt Signaling and Induces Apoptosis via AMP-activated Protein Kinase-dependent Phosphorylation of IRS-1 at Ser-794, Journal of Biological Chemistry, vol.282, issue.25, pp.28218069-18082, 2007.
DOI : 10.1074/jbc.M610101200

Y. Dagon, Y. Avraham, and E. Berry, AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2?? in adipocytes, Biochemical and Biophysical Research Communications, vol.340, issue.1, pp.43-47, 2006.
DOI : 10.1016/j.bbrc.2005.11.159