A. Recommended, Papers of particular interest, published within the annual period of review, have been highlighted as: * of special interest ** of outstanding interest Additional references related to this topic can also be found in the Current World Literature section in this issue

F. Falcone, H. Haas, and B. Gibbs, The human basophil: a new appreciation of its role in immune responses, Blood, vol.96, pp.4028-4038, 2000.

P. Fulkerson and M. Rothenberg, Targeting eosinophils in allergy, inflammation and beyond, Nature Reviews Drug Discovery, vol.114, issue.2, pp.117-129, 2013.
DOI : 10.1038/nrd3838

B. Lambrecht and H. Hammad, The airway epithelium in asthma, Nature Medicine, vol.184, issue.5, pp.684-692, 2012.
DOI : 10.1038/nm.2737

K. Bartemes and H. Kita, Dynamic role of epithelium-derived cytokines in asthma, Clinical Immunology, vol.143, issue.3, pp.222-235, 2012.
DOI : 10.1016/j.clim.2012.03.001

C. Corrigan, W. Wang, and Q. Meng, Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses, Journal of Allergy and Clinical Immunology, vol.128, issue.1, pp.116-124, 2011.
DOI : 10.1016/j.jaci.2011.03.043

Y. Haenuki, K. Matsushita, and S. Futatsugi-yumikura, A critical role of IL-33 in experimental allergic rhinitis, Journal of Allergy and Clinical Immunology, vol.130, issue.1, pp.184-194, 2012.
DOI : 10.1016/j.jaci.2012.02.013

K. Cho, J. Suh, and J. Sohn, IL-33 induces Th17-mediated airway inflammation via mast cells in ovalbumin-challenged mice, AJP: Lung Cellular and Molecular Physiology, vol.302, issue.4, pp.429-440, 2011.
DOI : 10.1152/ajplung.00252.2011

M. Headley, B. Zhou, and W. Shih, TSLP Conditions the Lung Immune Environment for the Generation of Pathogenic Innate and Antigen-Specific Adaptive Immune Responses, The Journal of Immunology, vol.182, issue.3, pp.1641-1647, 2009.
DOI : 10.4049/jimmunol.182.3.1641

M. Paplinska, J. Hermanowicz-salamon, and P. Nejman-gryz, Expression of eotaxins in the material from nasal brushing in asthma, allergic rhinitis and COPD patients, Cytokine, vol.60, issue.2, pp.393-399, 2012.
DOI : 10.1016/j.cyto.2012.07.001

L. Bao, V. Shi, and L. Chan, IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis, Molecular Immunology, vol.50, issue.1-2, pp.91-97, 2012.
DOI : 10.1016/j.molimm.2011.12.008

X. Ge, S. Ha, and F. Liu, Eosinophil-expressed galectin-3 regulates cell trafficking and migration, Frontiers in Pharmacology, vol.4, p.37, 2013.
DOI : 10.3389/fphar.2013.00037

M. Johansson, K. Gunderson, and E. Kelly, -integrins on circulating eosinophils after segmental antigen challenge, Clinical & Experimental Allergy, vol.89, issue.3, pp.292-303, 2013.
DOI : 10.1111/j.1365-2222.2012.04065.x

URL : https://hal.archives-ouvertes.fr/hal-00807148

M. Johansson and D. Mosher, Integrin Activation States and Eosinophil Recruitment in Asthma, Frontiers in Pharmacology, vol.4, p.33, 2013.
DOI : 10.3389/fphar.2013.00033

M. Masuoka, H. Shiraishi, and S. Ohta, Periostin promotes chronic allergic inflammation in response to Th2 cytokines, Journal of Clinical Investigation, vol.122, issue.7, pp.2590-2600, 2012.
DOI : 10.1172/JCI58978DS1

M. Ikutani, T. Yanagibashi, and M. Ogasawara, Identification of Innate IL-5-Producing Cells and Their Role in Lung Eosinophil Regulation and Antitumor Immunity, The Journal of Immunology, vol.188, issue.2, pp.703-713, 2012.
DOI : 10.4049/jimmunol.1101270

H. Tan and M. Rosenthal, IL-17 in lung disease: friend or foe?, Thorax, vol.292, issue.8, 2013.
DOI : 10.1136/thoraxjnl-2013-203307

S. Esnault, E. Kelly, and L. Nettenstrom, T lymphocytes, Clinical & Experimental Allergy, vol.292, issue.12, pp.1756-1764, 2012.
DOI : 10.1111/j.1365-2222.2012.04060.x

J. Eckl-dorna, A. Ellinger, and K. Blatt, Basophils are not the key antigen-presenting cells in allergic patients, Allergy, vol.11, issue.8 Pt 1, pp.601-608, 2012.
DOI : 10.1111/j.1398-9995.2012.02792.x

A. Otsuka, S. Nakajima, and M. Kubo, Basophils are required for the induction of Th2 immunity to haptens and peptide antigens, Nature Communications, vol.131, p.1738, 2013.
DOI : 10.1038/ncomms2740

B. Sullivan, H. Liang, and J. Bando, Genetic analysis of basophil function in vivo, Nature Immunology, vol.147, issue.6, pp.527-535, 2011.
DOI : 10.1165/rcmb.2005-0417OC

K. Wakahara, V. Van, and N. Baba, Basophils are recruited to inflamed lungs and exacerbate memory Th2 responses in mice and humans, Allergy, vol.16, issue.2, pp.180-189, 2013.
DOI : 10.1111/all.12072

*. Egawa, M. Mukai, K. Yoshikawa, and S. , Inflammatory Monocytes Recruited to Allergic Skin Acquire an Anti-inflammatory M2 Phenotype via Basophil-Derived Interleukin-4, Immunity, vol.38, issue.3, pp.570-580, 2013.
DOI : 10.1016/j.immuni.2012.11.014

H. Han, M. Headley, and W. Xu, Thymic Stromal Lymphopoietin Amplifies the Differentiation of Alternatively Activated Macrophages, The Journal of Immunology, vol.190, issue.3, pp.904-912, 2013.
DOI : 10.4049/jimmunol.1201808

M. Siracusa, S. Saenz, and D. Hill, TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation, Nature, vol.181, issue.7363, pp.229-233, 2012.
DOI : 10.1038/nature10329

T. Uhm, B. Kim, and I. Chung, Eosinophil Development, Regulation of Eosinophil-Specific Genes, and Role of Eosinophils in the Pathogenesis of Asthma, Allergy, Asthma and Immunology Research, vol.4, issue.2, pp.68-79, 2012.
DOI : 10.4168/aair.2012.4.2.68

Y. Baba, K. Maeda, and T. Yashiro, Involvement of PU.1 in Mast Cell/Basophil-Specific Function of the Human IL1RL1/ST2 Promoter, Allergology International, vol.61, issue.3, pp.461-467, 2012.
DOI : 10.2332/allergolint.12-OA-0424

K. Matsuoka, H. Shitara, and C. Taya, Novel Basophil- or Eosinophil-Depleted Mouse Models for Functional Analyses of Allergic Inflammation, PLoS ONE, vol.183, issue.4, p.60958, 2013.
DOI : 10.1371/journal.pone.0060958.s001

E. Bouzigon, V. Chaudru, and A. Carpentier, Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands, European Journal of Human Genetics, vol.12, issue.11, pp.955-963, 2004.
DOI : 10.1038/sj.ejhg.5201241

G. Pilia, W. Chen, and A. Scuteri, Heritability of Cardiovascular and Personality Traits in 6,148 Sardinians, PLoS Genetics, vol.6, issue.8, p.132, 2006.
DOI : 10.1371/journal.pgen.0020132.st003

M. Kang, H. Yu, and J. Seo, GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness, Human Immunology, vol.73, issue.9, pp.954-959, 2012.
DOI : 10.1016/j.humimm.2012.06.009

K. Takeuchi, Y. Mashimo, and N. Shimojo, Functional variants in the thromboxane A2 receptor gene are associated with lung function in childhood-onset asthma, Clinical & Experimental Allergy, vol.4, issue.4, pp.413-424, 2013.
DOI : 10.1111/cea.12058

I. Ungvari, E. Hadadi, and V. Virag, Implication of BIRC5 in asthma pathogenesis, International Immunology, vol.24, issue.5, pp.293-301, 2012.
DOI : 10.1093/intimm/dxs007

D. Gudbjartsson, U. Bjornsdottir, and E. Halapi, Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction, Nature Genetics, vol.447, issue.3, pp.342-347, 2009.
DOI : 10.1038/ng1245

M. Nalls, D. Couper, and T. Tanaka, Multiple Loci Are Associated with White Blood Cell Phenotypes, PLoS Genetics, vol.81, issue.6, p.1002113, 2011.
DOI : 10.1371/journal.pgen.1002113.s019

Y. Okada, T. Hirota, and Y. Kamatani, Identification of Nine Novel Loci Associated with White Blood Cell Subtypes in a Japanese Population, PLoS Genetics, vol.24, issue.6, p.1002067, 2011.
DOI : 10.1371/journal.pgen.1002067.s008

M. Rothenberg, J. Spergel, and J. Sherrill, Common variants at 5q22 associate with pediatric eosinophilic esophagitis, Nature Genetics, vol.4, issue.4, pp.289-291, 2010.
DOI : 10.1038/ng.547