M. Hedger and B. Hales, Immunophysiology of the male reproductive tract In Knobil and Neill' s physiology of reproduction, Amsterdam, pp.1195-1286, 2006.

A. Meinhardt and M. Hedger, Immunological, paracrine and endocrine aspects of testicular immune privilege, Molecular and Cellular Endocrinology, vol.335, issue.1, pp.60-68, 2010.
DOI : 10.1016/j.mce.2010.03.022

M. Hedger, Immunophysiology and Pathology of Inflammation in the Testis and Epididymis, Journal of Andrology, vol.32, issue.6, pp.625-640, 2011.
DOI : 10.2164/jandrol.111.012989

B. Setchell, J. Voglmayr, and G. Waites, A blood-testis barrier restricting passage from blood into rete testis fluid but not into lymph, The Journal of Physiology, vol.200, issue.1
DOI : 10.1113/jphysiol.1969.sp008682

E. Dubé and D. Cyr, The Blood-Epididymis Barrier and Human Male Fertility, Adv Exp Med Biol, vol.763, pp.218-236, 2012.
DOI : 10.1007/978-1-4614-4711-5_11

N. Da-silva, V. Cortez-retamozo, H. Reinecker, M. Wildgruber, E. Hill et al., A dense network of dendritic cells populates the murine epididymis, Reproduction, vol.141, issue.5, pp.141653-663, 2011.
DOI : 10.1530/REP-10-0493

J. Coombes and F. Powrie, Dendritic cells in intestinal immune regulation, Nature Reviews Immunology, vol.22, issue.6, pp.435-446, 2008.
DOI : 10.1038/nri2335

K. Lewis and B. Reizis, Dendritic Cells: Arbiters of Immunity and Immunological Tolerance, Cold Spring Harbor Perspectives in Biology, vol.4, issue.8, 2013.
DOI : 10.1101/cshperspect.a007401

M. Swiecki and M. Colonna, Unraveling the functions of plasmacytoid dendritic cells during viral infections, autoimmunity, and tolerance, Immunological Reviews, vol.205, issue.Suppl 5, pp.142-162, 2010.
DOI : 10.1111/j.0105-2896.2009.00881.x

S. Schmidt, A. Nino-castro, and J. Schultze, Regulatory dendritic cells: there is more than just immune activation, Frontiers in Immunology, vol.3, pp.274-284, 2012.
DOI : 10.3389/fimmu.2012.00274

URL : http://doi.org/10.3389/fimmu.2012.00274

S. Manicassamy and B. Pulendran, Dendritic cell control of tolerogenic responses, Immunological Reviews, vol.206, issue.Suppl. 1, pp.206-227, 2011.
DOI : 10.1111/j.1600-065X.2011.01015.x

J. Harden and N. Egilmez, Indoleamine 2,3-Dioxygenase and Dendritic Cell Tolerogenicity, Immunological Investigations, vol.25, issue.2, pp.6-7738
DOI : 10.1111/j.1600-6143.2011.03624.x

L. Huang, B. Baban, B. Johnson, and A. Mellor, Dendritic Cells, Indoleamine 2,3 Dioxygenase and Acquired Immune Privilege, International Reviews of Immunology, vol.106, issue.2, pp.133-155, 2010.
DOI : 10.4049/jimmunol.0900408

G. Matteoli, E. Mazzini, I. Iliev, E. Mileti, F. Fallarino et al., Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction, Gut, vol.59, issue.5, pp.59595-604, 2010.
DOI : 10.1136/gut.2009.185108

R. Yoshida, T. Nukiwa, Y. Watanabe, M. Fujiwara, F. Hirata et al., Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice, Archives of Biochemistry and Biophysics, vol.203, issue.1, pp.343-351, 1980.
DOI : 10.1016/0003-9861(80)90185-X

S. Yamamoto and O. Hayaishi, Tryptophan pyrrolase of rabbit intestine. D-and L-tryptophan-cleaving enzyme or enzymes, J Biol Chem, vol.242, pp.5260-5266, 1967.

A. Mellor and D. Munn, Ido expression by dendritic cells: tolerance and tryptophan catabolism, Nature Reviews Immunology, vol.467, issue.10, pp.762-764, 2004.
DOI : 10.1016/S0041-1345(00)02792-5

O. Takikawa, Y. Tagawa, Y. Iwakura, R. Yoshida, and R. Truscott, Interferon-Gamma-Dependent/Independent Expression of Indoleamine 2,3-Dioxygenase, Adv Exp Med Biol, vol.467, pp.553-557, 1999.
DOI : 10.1007/978-1-4615-4709-9_68

A. Jrad-lamine, J. Henry-berger, P. Gourbeyre, C. Damon-soubeyrand, A. Lenoir et al., Deficient Tryptophan Catabolism along the Kynurenine Pathway Reveals That the Epididymis Is in a Unique Tolerogenic State, Journal of Biological Chemistry, vol.286, issue.10, pp.2868030-8042, 2011.
DOI : 10.1074/jbc.M110.172114

A. Jrad-lamine, J. Henry-berger, C. Damon-soubeyrand, F. Saez, A. Kocer et al., Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment, PLoS ONE, vol.59, issue.7, 2013.
DOI : 10.1371/journal.pone.0066494.t001

A. Britan, V. Maffre, S. Tone, and J. Drevet, Quantitative and spatial differences in the expression of tryptophan-metabolizing enzymes in mouse epididymis, Cell and Tissue Research, vol.203, issue.2, pp.301-310, 2006.
DOI : 10.1007/s00441-005-0151-7

B. Baban, P. Chandler, D. Mccool, B. Marshall, D. Munn et al., Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific, Journal of Reproductive Immunology, vol.61, issue.2, pp.67-77, 2004.
DOI : 10.1016/j.jri.2003.11.003

S. Tone, A. Britan, A. Jrad, V. Maffre, and J. Drevet, The mouse epididymis: A site of strong and constitutive expression of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase (IDO), International Congress Series, vol.1304, pp.233-240, 2007.
DOI : 10.1016/j.ics.2007.07.035

A. De-luca, S. Bozza, T. Zelante, S. Zagarella, D. Angelo et al., Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO, Cellular and Molecular Immunology, vol.176, issue.6, pp.459-470, 2010.
DOI : 10.1086/526500

F. Fallarino and U. Grohmann, Using an Ancient Tool for Igniting and Propagating Immune Tolerance: IDO as an Inducer and Amplifier of Regulatory T Cell Functions, Current Medicinal Chemistry, vol.18, issue.15, pp.2215-2221, 2011.
DOI : 10.2174/092986711795656027

H. Xu, G. Zhang, B. Ciric, and A. Rostani, IDO: A double-edged sword for TH1/TH2 regulation, Immunology Letters, vol.121, issue.1, pp.1-6, 2008.
DOI : 10.1016/j.imlet.2008.08.008

M. Platten, P. Ho, S. Youssef, P. Fontoura, H. Garren et al., Steinman L: Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite, Science, issue.5749, pp.310850-855, 2005.

C. Orabona, P. Puccetti, C. Vacca, S. Bicciato, A. Luchini et al., Toward the identification of a tolerogenic signature in IDO-competent dendritic cells, Blood, vol.107, issue.7, pp.2846-2854, 2006.
DOI : 10.1182/blood-2005-10-4077

E. Kwidzinski, J. Bunse, O. Aktas, D. Richter, L. Mutlu et al., Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation, The FASEB Journal, issue.10, pp.191347-1349, 2005.
DOI : 10.1096/fj.04-3228fje

T. Cooper, C. Yeung, R. Jones, M. Orgebin-crist, and B. Robaire, Rebuttal of a role for the epididymis in sperm quality control by phagocytosis of defective sperm, J Cell Sci, vol.115, pp.5-7, 2002.

T. Balaji, S. Aruna, M. Ramanathan, M. Srinivasan, and V. Menon, Suppression of constitutively expressed cyclooxygenase-2 in the epididymis of mice by nimesulide decreases sperm motility, Journal of Basic and Clinical Physiology and Pharmacology, vol.20, issue.4, pp.357-376, 2009.
DOI : 10.1515/JBCPP.2009.20.4.357

D. Johnston, S. Jelinsky, H. Bang, P. Dicandeloro, E. Wilson et al., The Mouse Epididymal Transcriptome: Transcriptional Profiling of Segmental Gene Expression in the Epididymis1, Biology of Reproduction, vol.73, issue.3, pp.404-413, 2005.
DOI : 10.1095/biolreprod.105.039719

. Smithcj, . Zhangy, . Koboldtcm, . Muhammadj, . Zweifelbs et al., Pharmacological analysis of cyclooxygenase-1 in inflammation, Proceedings of the National Academy of Sciences, vol.95, issue.22, pp.13313-13318, 1998.
DOI : 10.1073/pnas.95.22.13313

M. Chen, E. Boilard, P. Nigrovic, P. Clark, D. Xu et al., Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum???transfer arthritis, Arthritis & Rheumatism, vol.352, issue.69, pp.1354-1365, 2008.
DOI : 10.1002/art.23453

V. Blaho, M. Buczynski, E. Dennis, and C. Brown, Cyclooxygenase-1 Orchestrates Germinal Center Formation and Antibody Class-Switch via Regulation of IL-17, The Journal of Immunology, vol.183, issue.9, pp.5644-5653, 2009.
DOI : 10.4049/jimmunol.0901499

Y. Wan and R. Flavell, TGF-?? and Regulatory T Cell in Immunity and Autoimmunity, Journal of Clinical Immunology, vol.108, issue.6, pp.647-659, 2008.
DOI : 10.1007/s10875-008-9251-y

W. Chen, J. W. Hardegen, N. Lei, K. Li, L. Marinos et al., Conversion of peripheral CD4 + CD25-naive T cells to CD4 + CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3, J Exp Med, issue.12, pp.1981875-1886, 2003.

K. Desai, K. Flanders, and P. Kondaiah, Expression of transforming growth factor-?? isoforms in the rat male accessory sex organs and epididymis, Cell and Tissue Research, vol.294, issue.2, pp.271-277, 1998.
DOI : 10.1007/s004410051177

D. Bomgardner, U. Wehrenberg, and G. Rune, TGF-beta could be involved in paracrine actions in the epididymis of the marmoset monkey (Callithrix jacchus), J Androl, vol.20, issue.3, pp.375-383, 1999.

K. Desai and P. Kondaiah, Androgen ablation results in differential regulation of transforming growth factor-beta isoforms in rat male accessory sex organs and epididymis, Journal of Molecular Endocrinology, vol.24, issue.2, pp.253-260, 2000.
DOI : 10.1677/jme.0.0240253

N. Henderson, G. Cooke, and B. Robaire, Region-specific expression of androgen and growth factor pathway genes in the rat epididymis and the effects of dual 5alpha-reductase inhibition, pp.779-791

G. Zhao, L. Liaw, and B. Hogan, Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis, pp.1103-1112, 1998.

G. Zhao, Y. Chen, X. Liu, Z. Xu, and X. Qi, Mutation in Bmp7 Exacerbates the Phenotype of Bmp8a Mutants in Spermatogenesis and Epididymis, Developmental Biology, vol.240, issue.1
DOI : 10.1006/dbio.2001.0448

L. Borish and J. Steinke, 2. Cytokines and chemokines, Journal of Allergy and Clinical Immunology, vol.111, issue.2, pp.460-475, 2003.
DOI : 10.1067/mai.2003.108

G. Petitjean, M. Chevalier, F. Tibaoui, C. Didier, M. Manea et al., Level of double negative T cells, which produce TGF-?? and IL-10, predicts CD8 T-cell activation in primary HIV-1 infection, AIDS, vol.26, issue.2, pp.139-148
DOI : 10.1097/QAD.0b013e32834e1484

E. Veräjänkorva, P. Pöllänen, A. Hänninen, M. Martikainen, J. Sundström et al., IL-10 is highly expressed in the cryptorchid cryptepididymal epithelium: a probable mechanism preventing immune responses against autoantigenic spermatozoa in the epididymal tubule, International Journal of Andrology, vol.149, issue.3, pp.129-133, 2002.
DOI : 10.1016/0165-0378(94)90019-1

J. Hall, J. Grainger, S. Spencer, and Y. Belkaid, The Role of Retinoic Acid in Tolerance and Immunity, Immunity, vol.35, issue.1, pp.13-22, 2011.
DOI : 10.1016/j.immuni.2011.07.002

R. Pappas, M. Newcomer, and D. Ong, Endogenous Retinoids in Rat Epididymal Tissue and Rat and Human Spermatozoa1, Biology of Reproduction, vol.48, issue.2, pp.235-247, 1993.
DOI : 10.1095/biolreprod48.2.235

D. Ong, M. Newcomer, J. Lareyre, and M. Orgebin-crist, Epididymal retinoic acid-binding protein, Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, vol.1482, issue.1-2, pp.209-217, 2000.
DOI : 10.1016/S0167-4838(00)00156-4

S. Costa, K. Boekelheide, B. Vanderhyden, R. Seth, and M. Mcburney, Male Infertility Caused by Epididymal Dysfunction in Transgenic Mice Expressing a Dominant Negative Mutation of Retinoic Acid Receptor ??1, Biology of Reproduction, vol.56, issue.4, pp.985-990, 1997.
DOI : 10.1095/biolreprod56.4.985

L. Xu, A. Kitani, and W. Strober, Molecular mechanisms regulating TGF-??-induced Foxp3 expression, Mucosal Immunology, vol.181, issue.3, pp.230-238, 2010.
DOI : 10.1182/blood-2007-06-096438

D. Nashan, U. Malorny, C. Sorg, T. Cooper, and E. Nieschlag, Immuno-competent cells in the murine epididymis, International Journal of Andrology, vol.233, issue.1, pp.85-94, 1989.
DOI : 10.1126/science.2437650

D. Acquisto, F. Crompton, and T. , CD3+CD4???CD8??? (double negative) T cells: Saviours or villains of the immune response?, Biochemical Pharmacology, vol.82, issue.4, pp.333-340, 2011.
DOI : 10.1016/j.bcp.2011.05.019

URL : https://hal.archives-ouvertes.fr/hal-00718034

S. Juvet and L. Zhang, Double negative regulatory T cells in transplantation and autoimmunity: recent progress and future directions, Journal of Molecular Cell Biology, vol.4, issue.1, pp.48-58
DOI : 10.1093/jmcb/mjr043

F. Mcintyre, M. Young, K. Gao, J. , J. B. Zhang et al., Cutting Edge: In Vivo Trogocytosis as a Mechanism of Double Negative Regulatory T Cell-Mediated Antigen-Specific Suppression, The Journal of Immunology, vol.181, issue.4, pp.2271-2275, 2008.
DOI : 10.4049/jimmunol.181.4.2271

W. Chen, M. Ford, K. Young, and L. Zhang, The role and mechanisms of double negative regulatory T cells in the suppression of immune responses, Cell Mol Immunol, vol.5, pp.328-335, 2004.

K. Wing and S. Sakaguchi, Regulatory T cells exert checks and balances on self tolerance and autoimmunity, Nature Immunology, vol.104, issue.1, pp.7-13, 2010.
DOI : 10.1038/ni.1818

K. Wheeler, S. Tardif, C. Rival, B. Luu, E. Bui et al., Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy, Proceedings of the National Academy of Sciences, vol.108, issue.18, pp.7511-7516, 2011.
DOI : 10.1073/pnas.1017615108

S. Poglio, F. De-toni-costes, E. Arnaud, P. Laharrague, E. Espinosa et al., Adipose Tissue as a Dedicated Reservoir of Functional Mast Cell Progenitors, STEM CELLS, vol.246, issue.11, pp.2065-2072, 2010.
DOI : 10.1002/stem.523

S. Caspar-bauguil, B. Cousin, S. Bour, L. Casteilla, L. Penicaud et al., Adipose tissue lymphocytes: types and roles, Journal of Physiology and Biochemistry, vol.300, issue.4, pp.423-436, 2009.
DOI : 10.1007/BF03185938

D. Doherty, O. Farrelly, and C. , Innate and adaptive lymphoid cells in the human liver, Immunological Reviews, vol.174, issue.1, pp.5-20, 2000.
DOI : 10.1034/j.1600-0528.2002.017416.x

. Kaufman, gamma/delta and other unconventional T lymphocytes: what do they see and what do they do?, Proceedings of the National Academy of Sciences, vol.93, issue.6, pp.2272-2279, 1996.
DOI : 10.1073/pnas.93.6.2272

M. González, E. Gonzalez-rey, L. Rico, D. Büscher, and M. Delgado, Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses, Gastroenterology, vol.136, issue.3, pp.978-989, 2009.
DOI : 10.1053/j.gastro.2008.11.041

Y. Chu, G. Huddleston, A. Clancy, R. Harris, and T. Bartness, Epididymal Fat Is Necessary for Spermatogenesis, but not Testosterone Production or Copulatory Behavior, Endocrinology, vol.151, issue.12, pp.5669-5679, 2010.
DOI : 10.1210/en.2010-0772

A. Kazeem, The assessment of epididymal lymphatics within the concept of immunologically privileged sites, Lymphology, vol.16, pp.168-171, 1983.

. Guiton, The immunobiology of the mammalian epididymis: the black box is now open!. Basic and Clinical Andrology, p.8, 2013.
URL : https://hal.archives-ouvertes.fr/inserm-00879088