Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.

Abstract : : Allogeneic stem cell (SC)-based therapy is a promising tool for the treatment of a range of human degenerative and inflammatory diseases. Many reports highlighted the immune modulatory properties of some SC types, such as mesenchymal stromal cells (MSCs), but a comparative study with SCs of different origin, to assess whether immune regulation is a general SC property, is still lacking. To this aim, we applied highly standardized methods employed for MSC characterization to compare the immunological properties of bone marrow-MSCs, olfactory ectomesenchymal SCs, leptomeningeal SCs, and three different c-Kit-positive SC types, that is, amniotic fluid SCs, cardiac SCs, and lung SCs. We found that all the analyzed human SCs share a common pattern of immunological features, in terms of expression of activation markers ICAM-1, VCAM-1, HLA-ABC, and HLA-DR, modulatory activity toward purified T, B, and NK cells, lower immunogenicity of inflammatory-primed SCs as compared to resting SCs, and indoleamine-2,3-dioxygenase-activation as molecular inhibitory pathways, with some SC type-related peculiarities. Moreover, the SC types analyzed exert an anti-apoptotic effect toward not-activated immune effector cells (IECs). In addition, we found that the inhibitory behavior is not a constitutive property of SCs, but is acquired as a consequence of IEC activation, as previously described for MSCs. Thus, immune regulation is a general property of SCs and the characterization of this phenomenon may be useful for a proper therapeutic use of SCs.
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Stem Cells and Development, Mary Ann Liebert, 2013, 22 (22), pp.2990-3002. 〈10.1089/scd.2013.0204〉
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Mariano Di Trapani, Giulio Bassi, Mario Ricciardi, Emanuela Fontana, Francesco Bifari, et al.. Comparative Study of Immune Regulatory Properties of Stem Cells Derived from Different Tissues.. Stem Cells and Development, Mary Ann Liebert, 2013, 22 (22), pp.2990-3002. 〈10.1089/scd.2013.0204〉. 〈inserm-00868952〉

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