Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism

Abstract : Abnormalities in oxidativemetabolism, inflammation,and selective neuronal death are described features of Alzheimer 's disease (AD) pathology. Brain thiamine-dependent enzymes play an important role in energy metabolism and display reduced activity in AD. Thiamine (vitamin B1) deficiency (TD) induces regionally selective neuronal death in animal and human brains.
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Molecular Neurodegeneration, BioMed Central, 2013, 8 (Suppl 1), pp.P31. 〈10.1186/1750-1326-8-S1-P31〉
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François Mouton-Liger, Anne-Sophie Rebillat, Sarah Gourmaud, Audrey Leguen, Claire Paquet, et al.. Neuroprotective role of PKR in a model of neurodegeneration due to mild impairment of oxidative metabolism. Molecular Neurodegeneration, BioMed Central, 2013, 8 (Suppl 1), pp.P31. 〈10.1186/1750-1326-8-S1-P31〉. 〈inserm-00868757〉

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