The HLA-G low expressor genotype is associated with protection against bipolar disorder.

Abstract : Implication of immune processes in bipolar disorder (BD) has recently gained increasing attention. Tolerogenic molecules, among which HLA-G plays a prominent role, mediate the modulation of such processes. The HLA-G locus is characterized by a high number of polymorphisms including a functionally relevant 14 base pair (bp) insertion/deletion (Ins/Del) allele affecting the HLA-G expression. Here, we analyzed the distribution of this polymorphism in 561 BD patients and 161 healthy and found that the HLA-G 14bp Ins/Ins genotype was significantly more prevalent in healthy controls than in patients (corrected p; pc=0.032) and that the prevalence of such protective genotype is lower among patients born during the winter season as compared to those born in other periods (pc=0.006). Possible mechanisms between low HLA G expression and resistance to infections as well as potential relationships between infections in early life and susceptibility to BD are discussed.
Type de document :
Article dans une revue
Human Immunology, Elsevier, 2013, 74 (5), pp.593-7. 〈10.1016/j.humimm.2012.11.032〉
Liste complète des métadonnées

Littérature citée [49 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00864639
Contributeur : Georges Guellaen <>
Soumis le : lundi 23 septembre 2013 - 08:25:52
Dernière modification le : mercredi 18 juillet 2018 - 20:11:26
Document(s) archivé(s) le : mardi 24 décembre 2013 - 04:30:00

Fichiers

HLA-G_and_BD_manuscript_-1.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Monojit Debnath, Marc Busson, Stéphane Jamain, Bruno Etain, Nora Hamdani, et al.. The HLA-G low expressor genotype is associated with protection against bipolar disorder.. Human Immunology, Elsevier, 2013, 74 (5), pp.593-7. 〈10.1016/j.humimm.2012.11.032〉. 〈inserm-00864639〉

Partager

Métriques

Consultations de la notice

459

Téléchargements de fichiers

783