In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives.

Abstract : Given this widespread role for estrogen in human physiology, it is not surprising that estrogen influence the pathophysiology of numerous diseases, including cancer (of the reproductive tract as breast, endometrial but also colorectal, prostate...), as well as neurodegenerative, inflammatory-immune, cardiovascular and metabolic diseases, and osteoporosis. These actions are mediated by the activation of estrogen receptors (ER) alpha (ERα) and beta (ERβ), which regulate target gene transcription (genomic action) through two independent activation functions (AF)-1 and AF-2, but can also elicit rapid membrane initiated steroid signals (MISS). Targeted ER gene inactivation has shown that although ERβ plays an important role in the central nervous system and in the heart, ERα appears to play a prominent role in most of the other tissues. Pharmacological activation or inhibition of ERα and/or ERβ provides already the basis for many therapeutic interventions, from contraception or hormone replacement at menopause to prevention of the recurrence of breast cancer. However, the use of these estrogens or selective estrogen receptors modulators (SERMs) have also induced undesired effects. Thus, an important challenge consists now to uncouple the beneficial actions from other deleterious ones. We summarize here an in vivo molecular "dissection" that allows to delineate in mouse the role of the main "subfunctions" of the receptor. This could pave the way to an optimization of the ER modulation.
Type de document :
Article dans une revue
Annales d'Endocrinologie, Elsevier Masson, 2013, 74 (2), pp.82-9. 〈10.1016/j.ando.2013.03.001〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00852204
Contributeur : Marie Francoise Simon <>
Soumis le : mardi 20 août 2013 - 11:24:41
Dernière modification le : jeudi 22 août 2013 - 11:28:51

Identifiants

Collections

Citation

Jean-François Arnal, Pierre Gourdy, Françoise Lenfant. In vivo dissection of the estrogen receptor alpha: uncoupling of its physiological effects and medical perspectives.. Annales d'Endocrinologie, Elsevier Masson, 2013, 74 (2), pp.82-9. 〈10.1016/j.ando.2013.03.001〉. 〈inserm-00852204〉

Partager

Métriques

Consultations de la notice

92