Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.

Laurent Plawinski 1 Eduardo Anglés-Cano 2, *
* Auteur correspondant
2 Inserm UMR_S765
U765 - Risque Thrombotique et Mecanismes de l'Hemostase
Abstract : Thrombus lysis is the consequence of a restricted number of reactions localised on the surface of fibrin and cell membranes. A functional defect or an insufficient fibrinolytic response may result in thrombosis with severe or fatal clinical consequences. Despite this clinical exigency and a real progress in the knowledge of the different components of this system (plasminogen activators, inhibitors and receptors) including structure-function relationship unveiled by the crystal structure of plasminogen, the functional evaluation of fibrinolysis still remains a challenge in haemostasis. Interestingly, we recently discovered that circulating membrane microvesicles might be indicators of the fibrinolytic response to an inflammatory or prothrombotic process via their participation in a new mechanism of plasmin formation requiring a cross-talk between two different surfaces. We propose that the fibrinolytic activity conveyed by microvesicles could be the real source of fibrinolysis in circulating blood.
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Article dans une revue
Haematologica, Ferrata Storti Foundation, 2013, 98 (7), pp.e75-6. 〈10.3324/haematol.2013.088948〉
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http://www.hal.inserm.fr/inserm-00851463
Contributeur : Eduardo Angles-Cano <>
Soumis le : mercredi 14 août 2013 - 12:28:56
Dernière modification le : jeudi 24 mai 2018 - 11:52:01
Document(s) archivé(s) le : vendredi 15 novembre 2013 - 09:28:17

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Laurent Plawinski, Eduardo Anglés-Cano. Membrane microvesicles: a circulating source for fibrinolysis, new antithrombotic messengers.. Haematologica, Ferrata Storti Foundation, 2013, 98 (7), pp.e75-6. 〈10.3324/haematol.2013.088948〉. 〈inserm-00851463〉

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