J. Moore, Parasites and the Behavior of Animals, 2002.

B. Hart, Behavioral adaptations to pathogens and parasites: Five strategies, Neuroscience & Biobehavioral Reviews, vol.14, issue.3, pp.273-294, 1990.
DOI : 10.1016/S0149-7634(05)80038-7

B. Hart, Behavioral Adaptations to Parasites: An Ethological Approach, The Journal of Parasitology, vol.78, issue.2, pp.256-265, 1992.
DOI : 10.2307/3283472

V. Curtis, M. De-barra, and R. Aunger, Disgust as an adaptive system for disease avoidance behaviour, Philosophical Transactions of the Royal Society B: Biological Sciences, vol.23, issue.1491, pp.389-401, 2011.
DOI : 10.1098/rspb.2001.1932

D. Behringer, M. Butler, . Iv, and J. Shields, Ecology: Avoidance of disease by social lobsters, Nature, vol.49, issue.7092, p.421, 2006.
DOI : 10.1038/441421a

F. Libersat, A. Delago, and R. Gal, Manipulation of Host Behavior by Parasitic Insects and Insect Parasites, Annual Review of Entomology, vol.54, issue.1, pp.189-207, 2009.
DOI : 10.1146/annurev.ento.54.110807.090556

S. Klein, Parasite manipulation of the proximate mechanisms that mediate social behavior in vertebrates, Physiology & Behavior, vol.79, issue.3, pp.441-449, 2003.
DOI : 10.1016/S0031-9384(03)00163-X

N. Wilson-rich, M. Spivak, N. Fefferman, and P. Starks, Genetic, Individual, and Group Facilitation of Disease Resistance in Insect Societies, Annual Review of Entomology, vol.54, issue.1, pp.405-423, 2009.
DOI : 10.1146/annurev.ento.53.103106.093301

S. Cremer and S. Armitage, Social Immunity, Current Biology, vol.17, issue.16, pp.693-702, 2007.
DOI : 10.1016/j.cub.2007.06.008

O. Rueppell, M. Hayworth, and N. Ross, Altruistic self-removal of health-compromised honey bee workers from their hive, Journal of Evolutionary Biology, vol.19, issue.Suppl. 9, pp.1538-1546, 2010.
DOI : 10.1111/j.1420-9101.2010.02022.x

D. Downey, T. Higo, and M. Winston, Single and dual parasitic mite infestations on the honey bee Apis mellifera L. Insect Soc, pp.171-176, 2000.

A. Janmaat and M. Winston, The influence of pollen storage area and Varroa jacobsoni Oudemans parasitism on temporal caste structure in honey bees (Apis mellifera L.) Insect Soc, pp.177-182, 2000.

C. Dussaubat, A. Maisonnasse, D. Crauser, D. Beslay, G. Costagliola et al., Flight behavior and pheromone changes associated to Nosema ceranae infection of honey bee workers (Apis mellifera) in field conditions, Journal of Invertebrate Pathology, vol.113, issue.1, pp.42-51, 2013.
DOI : 10.1016/j.jip.2013.01.002

M. Goblirsch, Z. Huang, and M. Spivak, Physiological and Behavioral Changes in Honey Bees (Apis mellifera) Induced by Nosema ceranae Infection, PLoS ONE, vol.109, issue.3, p.58165, 2013.
DOI : 10.1371/journal.pone.0058165.t002

C. Alaux, N. Kemper, A. Krezschmar, and L. Conte, Brain, physiological and behavioral modulation induced by immune stimulation in honeybees (Apis mellifera): A potential mediator of social immunity?, Brain, Behavior, and Immunity, vol.26, issue.7, pp.1057-1060, 2012.
DOI : 10.1016/j.bbi.2012.04.004

L. Conte, Y. Ellis, M. Ritter, and W. , Varroa mites and honey bee health: can Varroa explain part of the colony losses? Apidologie, pp.353-363, 2010.

R. Rosenkranz, P. Aumeier, and B. Ziegelmann, Biology and control of Varroa destructor, Journal of Invertebrate Pathology, vol.103, pp.96-119, 2010.
DOI : 10.1016/j.jip.2009.07.016

X. Yang and D. Cox-foster, Effects of parasitization by Varroa destructor on survivorship and physiological traits of Apis mellifera in correlation with viral incidence and microbial challenge, Parasitology, vol.134, issue.03, pp.405-412, 2007.
DOI : 10.1126/science.226.4674.557

M. Higes, R. Martín-hernández, and A. Meana, in Europe: an emergent type C nosemosis, Apidologie, vol.64, issue.3, pp.375-392, 2010.
DOI : 10.1051/apido/2010019

I. Fries, F. Feng, A. Da-silva, S. Slemenda, and N. Pieniazek, Nosema ceranae n. sp. (Microspora, Nosematidae), morphological and molecular characterization of a microsporidian parasite of the Asian honey bee Apis cerana (Hymenoptera, Apidae), European Journal of Protistology, vol.32, issue.3, pp.356-365, 1996.
DOI : 10.1016/S0932-4739(96)80059-9

B. Williams, Unique physiology of host-parasite interactions in microsporidia infections, Cellular Microbiology, vol.50, issue.1, pp.1551-1560, 2009.
DOI : 10.1111/j.1462-5822.2009.01362.x

J. Kralj and S. Fuchs, ) foragers, Apidologie, vol.29, issue.28, pp.21-28, 2010.
DOI : 10.1051/apido/2009046

J. Kralj and S. Fuchs, foragers, Apidologie, vol.44, issue.5, pp.577-587, 2006.
DOI : 10.1051/apido:2006040

URL : https://hal.archives-ouvertes.fr/hal-00892221

G. Amdam, K. Hartfelder, K. Norberg, A. Hagen, and S. Omholt, Altered Physiology in Worker Honey Bees (Hymenoptera: Apidae) Infested with the Mite Varroa destructor (Acari: Varroidae): A Factor in Colony Loss During Overwintering?, Journal of Economic Entomology, vol.97, issue.3, pp.741-747, 2004.
DOI : 10.1093/jee/97.3.741

P. Bowen-walker and A. Gunn, The effect of the ectoparasitic mite, Varroa destructor on adult worker honeybee (Apis mellifera) emergence weights, water, protein, carbohydrate, and lipid levels, Entomologia Experimentalis et Applicata, vol.101, issue.3, pp.207-217, 2001.
DOI : 10.1046/j.1570-7458.2001.00905.x

R. Kucharski, C. Mitri, Y. Grau, and R. Maleszka, Characterization of a metabotropic glutamate receptor in the honeybee (Apis mellifera): implications for memory formation, Invertebrate Neuroscience, vol.75, issue.2, pp.99-108, 2007.
DOI : 10.1007/s10158-007-0045-3

K. Antunez, R. Martin-hernandez, L. Prieto, A. Meana, P. Zunino et al., ), Environmental Microbiology, vol.21, issue.9, pp.2284-2290, 2009.
DOI : 10.1111/j.1462-2920.2009.01953.x

C. Dussaubat, A. Maisonnasse, C. Alaux, S. Tchamitchan, J. Brunet et al., Nosema spp. Infection Alters Pheromone Production in Honey Bees (Apis mellifera), Journal of Chemical Ecology, vol.63, issue.5, pp.522-525, 2010.
DOI : 10.1007/s10886-010-9786-2

C. Whitfield, A. Cziko, and G. Robinson, Gene Expression Profiles in the Brain Predict Behavior in Individual Honey Bees, Science, vol.302, issue.5643, pp.296-299, 2003.
DOI : 10.1126/science.1086807

L. Mußig, A. Richlitzki, R. Rößler, D. Eisenhardt, R. Menzel et al., Acute Disruption of the NMDA Receptor Subunit NR1 in the Honeybee Brain Selectively Impairs Memory Formation, Journal of Neuroscience, vol.30, issue.23, pp.7817-7825, 2010.
DOI : 10.1523/JNEUROSCI.5543-09.2010

C. Mayack and D. Naug, Energetic stress in the honeybee Apis mellifera from Nosema ceranae infection, Journal of Invertebrate Pathology, vol.100, issue.3, pp.185-188, 2009.
DOI : 10.1016/j.jip.2008.12.001

S. Ament, C. Blatti, C. Alaux, M. Wheeler, A. Toth et al., New meta-analysis tools reveal common transcriptional regulatory basis for multiple determinants of behavior, Proceedings of the National Academy of Sciences, vol.109, issue.26, pp.1801-1810, 2012.
DOI : 10.1073/pnas.1205283109

A. Zayed and G. Robinson, Understanding the Relationship Between Brain Gene Expression and Social Behavior: Lessons from the Honey Bee, Annual Review of Genetics, vol.46, issue.1, pp.589-613, 2012.
DOI : 10.1146/annurev-genet-110711-155517

F. Richard, A. A. Grozinger, and C. , Modulation of social interactions by immune stimulation in honey bee, Apis mellifera, workers, BMC Biology, vol.6, issue.1, pp.50-62, 2008.
DOI : 10.1186/1741-7007-6-50

URL : https://hal.archives-ouvertes.fr/hal-00384087

F. Richard, H. Holt, and C. Grozinger, Effects of immunostimulation on social behavior, chemical communication and genome-wide gene expression in honey bee workers (Apis mellifera), BMC Genomics, vol.13, issue.1, p.558, 2012.
DOI : 10.1007/s00359-011-0654-5

URL : https://hal.archives-ouvertes.fr/hal-00872884

D. Baracchi, A. Fadda, and S. Turillazzi, Evidence for antiseptic behavior towards sick adult bees in honey bee colonies, J Insect Physiol

M. Blum, A. Novak, S. Taber, and . Iii, 10-Hydroxy-Dgr2-Decenoic Acid, an Antibiotic Found in Royal Jelly, Science, vol.130, issue.3373, pp.452-453, 1959.
DOI : 10.1126/science.130.3373.452

S. Krishnaswamy, S. Duan, L. Von-moltke, D. Greenblatt, and M. Court, Validation of Serotonin (5-Hydroxtryptamine) as an in Vitro Substrate Probe for Human UDP-Glucuronosyltransferase (UGT) 1A6, Drug Metabolism and Disposition, vol.31, issue.1, pp.133-139, 2003.
DOI : 10.1124/dmd.31.1.133

S. Krishnaswamy, Q. Hao, L. Von-moltke, D. Greenblatt, and M. Court, EVALUATION OF 5-HYDROXYTRYPTOPHOL AND OTHER ENDOGENOUS SEROTONIN (5-HYDROXYTRYPTAMINE) ANALOGS AS SUBSTRATES FOR UDP-GLUCURONOSYLTRANSFERASE 1A6, Drug Metabolism and Disposition, vol.32, issue.8, pp.862-869, 2004.
DOI : 10.1124/dmd.32.8.862

K. Itäaho, M. Court, P. Uutela, R. Kostiainen, A. Radominska-pandya et al., Dopamine Is a Low-Affinity and High-Specificity Substrate for the Human UDP-Glucuronosyltransferase 1A10, Drug Metabolism and Disposition, vol.37, issue.4, pp.768-775, 2009.
DOI : 10.1124/dmd.108.025692

C. Alaux, L. Conte, Y. Adams, H. Rodriguez-zas, S. Grozinger et al., Regulation of brain gene expression in honey bees by brood pheromone, Genes, Brain and Behavior, vol.103, issue.3, pp.309-319, 2009.
DOI : 10.1111/j.1601-183X.2009.00480.x

M. Salvy, C. Martin, A. Bagneres, E. Provost, M. Roux et al., Modifications of the cuticular hydrocarbon profile of Apis mellifera worker bees in the presence of the ectoparasitic mite Varroa jacobsoni in brood cells, Parasitology, vol.122, issue.02, pp.145-159, 2001.
DOI : 10.1017/S0031182001007181

R. Kather, F. Drijfhout, and S. Martin, Task Group Differences in Cuticular Lipids in the Honey Bee Apis mellifera, Journal of Chemical Ecology, vol.27, issue.2, pp.205-212, 2011.
DOI : 10.1007/s10886-011-9909-4

J. Scholl and D. Naug, Olfactory discrimination of age-specific hydrocarbons generates behavioral segregation in a honeybee colony, Behavioral Ecology and Sociobiology, vol.364, issue.10, pp.1967-1973, 2011.
DOI : 10.1007/s00265-011-1206-2

R. Howard and G. Blomquist, ECOLOGICAL, BEHAVIORAL, AND BIOCHEMICAL ASPECTS OF INSECT HYDROCARBONS, Annual Review of Entomology, vol.50, issue.1, pp.371-393, 2005.
DOI : 10.1146/annurev.ento.50.071803.130359

G. Blomquist and A. Bagneres, Insect hydrocarbons: biology, biochemistry and chemical ecology, 2010.
DOI : 10.1017/CBO9780511711909

E. Plettner, G. Sutherland, K. Slessor, and M. Winston, Why not be a queen? Regioselectivity in mandibular secretions of honeybee castes, Journal of Chemical Ecology, vol.83, issue.7, pp.1017-1029, 1995.
DOI : 10.1007/BF02033805

I. Phillips and E. Shephard, Flavin-containing monooxygenases: mutations, disease and drug response, Trends in Pharmacological Sciences, vol.29, issue.6, pp.294-301, 2008.
DOI : 10.1016/j.tips.2008.03.004

N. Wakabayashi-ito, O. Doherty, H. Moriyama, X. Breakefield, J. Gusella et al., dtorsin, the Drosophila Ortholog of the Early-Onset Dystonia TOR1A (DYT1), Plays a Novel Role in Dopamine Metabolism, PLoS ONE, vol.1, issue.Pt 12, p.26183, 2011.
DOI : 10.1371/journal.pone.0026183.s008

R. Neumüller, C. Richter, A. Fischer, M. Novatchkova, K. Neumuller et al., Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi, Cell Stem Cell, vol.8, issue.5, pp.580-593, 2011.
DOI : 10.1016/j.stem.2011.02.022

A. Brockmann, S. Annangudi, T. Richmond, S. Ament, F. Xie et al., Quantitative peptidomics reveal brain peptide signatures of behavior, Proceedings of the National Academy of Sciences, vol.106, issue.7, pp.2383-2388, 2009.
DOI : 10.1073/pnas.0813021106

A. Rafaeli, Pheromone biosynthesis activating neuropeptide (PBAN): Regulatory role and mode of action, General and Comparative Endocrinology, vol.162, issue.1, pp.69-78, 2009.
DOI : 10.1016/j.ygcen.2008.04.004

Y. Fan, A. Rafaeli, C. Gileadi, E. Kubli, and S. Applebaum, Drosophila melanogaster sex peptide stimulates juvenile hormone synthesis and depresses sex pheromone production in Helicoverpa armigera, Journal of Insect Physiology, vol.45, issue.2, pp.127-133, 1999.
DOI : 10.1016/S0022-1910(98)00106-1

N. Zioni, V. Soroker, and N. Chejanovsky, Replication of Varroa destructor virus 1 (VDV-1) and a Varroa destructor virus 1???deformed wing virus recombinant (VDV-1???DWV) in the head of the honey bee, Virology, vol.417, issue.1, pp.106-112, 2011.
DOI : 10.1016/j.virol.2011.05.009

K. Shah, E. Evans, and M. Pizzorno, Localization of deformed wing virus (DWV) in the brains of the honeybee, Apis mellifera Linnaeus, Virology Journal, vol.6, issue.1, pp.182-188, 2009.
DOI : 10.1186/1743-422X-6-182

E. Genersch and A. M. , L.), Veterinary Research, vol.41, issue.6, pp.54-73, 2010.
DOI : 10.1051/vetres/2010027

URL : https://hal.archives-ouvertes.fr/hal-00903174

C. Costa, G. Tanner, M. Lodesani, L. Maistrello, and P. Neumann, Negative correlation between Nosema ceranae spore loads and deformed wing virus infection levels in adult honey bee workers, Journal of Invertebrate Pathology, vol.108, issue.3, pp.224-225, 2011.
DOI : 10.1016/j.jip.2011.08.012

C. Dussaubat, J. Brunet, M. Higes, J. Colbourned, J. Lopez et al., Gut Pathology and Responses to the Microsporidium Nosema ceranae in the Honey Bee Apis mellifera, PLoS ONE, vol.35, issue.5, p.37017, 2012.
DOI : 10.1371/journal.pone.0037017.s006

J. Kralj, A. Brockmann, S. Fuchs, and J. Tautz, The parasitic mite Varroa destructor affects non-associative learning in honey bee foragers, Apis mellifera L., Journal of Comparative Physiology A, vol.102, issue.3, pp.363-370, 2007.
DOI : 10.1007/s00359-006-0192-8

A. Si, P. Helliwell, and R. Maleszka, Effects of NMDA receptor antagonists on olfactory learning and memory in the honeybee (Apis mellifera), Pharmacology Biochemistry and Behavior, vol.77, issue.2
DOI : 10.1016/j.pbb.2003.09.023

S. Fahrbach, STRUCTURE OF THE MUSHROOM BODIES OF THE INSECT BRAIN, Annual Review of Entomology, vol.51, issue.1, pp.209-232, 2006.
DOI : 10.1146/annurev.ento.51.110104.150954

S. Farris, G. Robinson, and S. Fahrbach, Experience and age-related outgrowth of intrinsic neurons in the mushroom bodies of the adult worker honeybee, J Neurosci, vol.21, pp.6395-6404, 2001.

M. Hammer and R. Menzel, Learning and memory in the honeybee, J Neurosci, vol.15, pp.1617-1630, 1995.

P. Kurshan, I. Hamilton, J. Mustard, and A. Mercer, Developmental changes in expression patterns of two dopamine receptor genes in mushroom bodies of the honeybee,Apis mellifera, The Journal of Comparative Neurology, vol.10, issue.1, pp.91-103, 2003.
DOI : 10.1002/cne.10864

Y. Kim, H. Lee, and K. Han, D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila, Journal of Neuroscience, vol.27, issue.29, pp.7640-7647, 2007.
DOI : 10.1523/JNEUROSCI.1167-07.2007

R. Menzel and U. Müller, Learning and Memory in Honeybees: From Behavior to Neural Substrates, Annual Review of Neuroscience, vol.19, issue.1, pp.379-404, 1996.
DOI : 10.1146/annurev.ne.19.030196.002115

D. Shakiryanova, G. Zettel, T. Gu, R. Hewes, and E. Levitan, Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal, Proceedings of the National Academy of Sciences, vol.108, issue.11, pp.4477-4481, 2011.
DOI : 10.1073/pnas.1017837108

B. Fussnecker and C. Grozinger, ), Insect Molecular Biology, vol.302, issue.7114, pp.515-522, 2008.
DOI : 10.1111/j.1365-2583.2008.00819.x

C. Lutz, S. Rodriguez-zas, S. Fahrbach, and G. Robinson, Transcriptional response to foraging experience in the honey bee mushroom bodies, Developmental Neurobiology, vol.4, issue.2, pp.153-166, 2012.
DOI : 10.1002/dneu.20929

D. Biron, L. Marché, F. Ponton, H. Loxdale, N. Galéotti et al., Behavioural manipulation in a grasshopper harbouring hairworm: a proteomics approach, Proceedings of the Royal Society B: Biological Sciences, vol.18, issue.1, pp.2117-2126, 2005.
DOI : 10.1006/jtbi.1996.0346

T. Lefevre, F. Thomas, S. Rave, D. Patre, R. L. et al., Trypanosoma brucei brucei induces alteration in the head proteome of the tsetse fly vector Glossina palpalis gambiensis, Insect Molecular Biology, vol.186, issue.6, pp.651-660, 2007.
DOI : 10.1111/j.1365-2583.2007.00761.x

D. Van-engelsdorp and M. Meixner, A historical review of managed honey bee populations in Europe and the United States and the factors that may affect them, Journal of Invertebrate Pathology, vol.103, pp.80-95, 2010.
DOI : 10.1016/j.jip.2009.06.011

C. Alaux, C. Dantec, H. Parrinello, L. Conte, and Y. , Nutrigenomics in honey bees: digital gene expression analysis of pollen's nutritive effects on healthy and varroa-parasitized bees, BMC Genomics, vol.11, issue.11, p.496, 2011.
DOI : 10.1186/1471-2164-11-282

M. Breed, S. Perry, and L. Biostad, Testing the blank slate hypothesis: why honey bee colonies accept young bees, Insectes Sociaux, vol.51, issue.1, pp.12-16, 2004.
DOI : 10.1007/s00040-003-0698-9

R. Page, R. Metcalf, R. Metcalf, E. Erickson, and R. Lampman, Extractable hydrocarbons and kin recognition in honeybee, pp.745-756, 1991.

R. Reyment, Compositional data analysis, Terra Nova, vol.1, issue.1, pp.29-34, 1989.
DOI : 10.1111/j.1365-3121.1989.tb00322.x

S. Anders and W. Huber, Differential expression analysis for sequence count data, Genome Biology, vol.11, issue.10, p.106, 2010.
DOI : 10.1186/gb-2010-11-10-r106

M. Priooznia, V. Nagarajan, and Y. Deng, GeneVenn - A web application for comparing gene lists using Venn diagrams, Bioinformation, vol.1, issue.10, pp.420-422, 2007.
DOI : 10.6026/97320630001420

S. Kim, J. Lund, M. Kiraly, K. Duke, M. Jiang et al., A Gene Expression Map for Caenorhabditis elegans, Science, vol.293, issue.5537, pp.2087-2092, 2001.
DOI : 10.1126/science.1061603

D. Huang, B. Sherman, and R. Lempicki, Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources, Nature Protocols, vol.99, issue.1, pp.44-57, 2009.
DOI : 10.1038/nprot.2008.211

D. Huang, B. Sherman, and R. Lempicki, Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists, Nucleic Acids Research, vol.37, issue.1, pp.1-13, 2009.
DOI : 10.1093/nar/gkn923

. Mcdonnell, Ecto- and endoparasite induce similar chemical and brain neurogenomic responses in the honey bee (Apis mellifera), BMC Ecology, vol.13, issue.1, p.25, 2013.
DOI : 10.1093/nar/gkn923

URL : https://hal.archives-ouvertes.fr/inserm-00848671