Dolosigranulum pigrum keratitis: a three-case series

Abstract : BackgroundDolosigranulum pigrum is a commensal inhabitant of the upper respiratory tract suspected to be responsible for ocular infections but no well-described case of D. pigrum corneal infection has been reported. Herein culture and PCR-sequencing-based investigations of corneal scraping specimens confirmed D. pigrum keratitis in three patients.Case presentationThree elderly patients presented with unilateral keratitis. None was a corneal-contact lens wearer, one had previous cataract surgery and another suffered rheumatoid arthritis sicca syndrome. Culturing the corneal scraping specimen was positive for two cases and PCR-sequencing of bacterial 16S rDNA in the presence of negative controls identified D. pigrum in three cases. The two D. pigrum isolates were in-vitro susceptible to penicillin G, amoxicillin, doxycycline, rifampicin and gentamicin. In all cases, surgical treatment of corneal thinning was necessary, but corneal perforation occurred in two cases despite intensive antimicrobial treatment with ticarcillin, gentamicin and vancomycin or levofloxacin eye drops leading to enucleation in one case. Conclusions D. pigrum is the likely cause of corneal infection in three patients, with effective antibiotic treatment in two patients.
Type de document :
Article dans une revue
BMC Ophthalmology, BioMed Central, 2013, 13 (1), pp.31
Liste complète des métadonnées

Littérature citée [9 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00844109
Contributeur : Ed. Bmc <>
Soumis le : vendredi 12 juillet 2013 - 18:09:07
Dernière modification le : mercredi 18 avril 2018 - 11:42:05
Document(s) archivé(s) le : lundi 14 octobre 2013 - 11:21:03

Fichiers

Identifiants

  • HAL Id : inserm-00844109, version 1

Collections

Citation

Magali Sampo, Oaufeh Ghazouani, Dominique Cadiou, Elodie Trichet, Louis Hoffart, et al.. Dolosigranulum pigrum keratitis: a three-case series. BMC Ophthalmology, BioMed Central, 2013, 13 (1), pp.31. 〈inserm-00844109〉

Partager

Métriques

Consultations de la notice

925

Téléchargements de fichiers

258