S. Abbreviations, Society for Immunotherapy of Cancer; TILs: Tumor infiltrating T lymphocytes; TECs: Tumor endothelial cells

. Fasl, Fas-ligand; IL-10: Interleukin-10; TGF-?: Transforming growth factor-beta

F. Pagès, J. Galon, M. Dieu-nosjean, E. Tartour, C. Sautès-fridman et al., Immune infiltration in human tumors: a prognostic factor that should not be ignored, Oncogene, vol.173, issue.8, pp.1093-1102, 2010.
DOI : 10.1038/nrc1586

C. Clemente, M. Mihm, . Jr, R. Bufalino, S. Zurrida et al., Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma, Cancer, vol.77, issue.7, pp.1303-1310, 1996.
DOI : 10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.3.CO;2-0

K. Schumacher, W. Haensch, C. Roefzaad, P. Schlag, K. Schumacher et al., Prognostic significance of activated CD8(+) T cell infiltrations within esophageal carcinomas, Cancer Res, vol.61, pp.3932-3936, 2001.

L. Zhang, J. Conejo-garcia, D. Katsaros, P. Gimotty, M. Massobrio et al., Intratumoral T Cells, Recurrence, and Survival in Epithelial Ovarian Cancer, New England Journal of Medicine, vol.348, issue.3, pp.203-213, 2003.
DOI : 10.1056/NEJMoa020177

Y. Naito, K. Saito, K. Shiiba, A. Ohuchi, K. Saigenji et al., CD8 + T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer, Cancer Res, vol.58, pp.3491-3494, 1998.

R. Buckanovich, A. Facciabene, S. Kim, F. Benencia, D. Sasaroli et al., Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy, Nature Medicine, vol.32, issue.1, pp.28-36, 2008.
DOI : 10.1182/blood-2004-05-1906

A. Mellor and D. Munn, Creating immune privilege: active local suppression that benefits friends, but protects foes, Nature Reviews Immunology, vol.176, issue.1, pp.74-80, 2008.
DOI : 10.1038/nri2233

M. Spiotto and H. Schreiber, Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells, Cancer Immunology, vol.5, pp.8-12, 2005.

B. Zhang, N. Bowerman, J. Salama, H. Schmidt, M. Spiotto et al., Induced sensitization of tumor stroma leads to eradication of established cancer by T cells, The Journal of Experimental Medicine, vol.9, issue.1, pp.49-55, 2007.
DOI : 10.1073/pnas.111161198

M. Sharma, B. Baban, P. Chandler, D. Hou, N. Singh et al., Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamine 2,3-dioxygenase, Journal of Clinical Investigation, vol.117, issue.9, pp.2570-2582, 2007.
DOI : 10.1172/JCI31911DS1

D. Munn, Blocking IDO activity to enhance anti-tumor immunity, Frontiers in Bioscience, vol.4, issue.2, pp.734-745, 2012.
DOI : 10.2741/e414

D. Munn, GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase, Immunity, vol.22, issue.5, pp.633-642, 2005.
DOI : 10.1016/j.immuni.2005.03.013

D. Munn and A. Mellor, Indoleamine 2,3 dioxygenase and metabolic control of immune responses, Trends in Immunology, vol.34, issue.3, pp.137-143, 2012.
DOI : 10.1016/j.it.2012.10.001

S. Ugel, E. Peranzoni, G. Desantis, M. Chioda, S. Walter et al., Immune Tolerance to Tumor Antigens Occurs in a Specialized Environment of the Spleen, Cell Reports, vol.2, issue.3, pp.628-639, 2012.
DOI : 10.1016/j.celrep.2012.08.006

T. Gajewski, J. Louahed, and V. Brichard, Gene Signature in Melanoma Associated With Clinical Activity, The Cancer Journal, vol.16, issue.4, pp.399-403, 2010.
DOI : 10.1097/PPO.0b013e3181eacbd8

M. Fuertes, A. Kacha, J. Kline, S. Woo, D. Kranz et al., dendritic cells, The Journal of Experimental Medicine, vol.61, issue.10, pp.2005-2016, 2011.
DOI : 10.1158/0008-5472.CAN-07-5324

Y. Zheng, Y. Zha, G. Driessens, F. Locke, and T. Gajewski, Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo, The Journal of Experimental Medicine, vol.162, issue.12, pp.2157-2163, 2012.
DOI : 10.1111/j.1600-065X.2008.00647.x

A. Cipponi, M. Mercier, T. Seremet, J. Baurain, I. Theate et al., Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases, Cancer Research, vol.72, issue.16, pp.4997-5002, 2012.
DOI : 10.1158/0008-5472.CAN-12-1377

S. Budhu, J. Loike, A. Pandolfi, S. Han, G. Catalano et al., T cell concentration determines their efficiency in killing cognate antigen???expressing syngeneic mammalian cells in vitro and in mouse tissues, The Journal of Experimental Medicine, vol.46, issue.1, pp.223-235, 2010.
DOI : 10.1016/0022-1759(86)90079-7

H. Torikai, A. Reik, P. Liu, Y. Zhou, L. Zhang et al., A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR, Blood, vol.119, issue.24, pp.5697-5705, 2012.
DOI : 10.1182/blood-2012-01-405365

S. Topalian, F. Hodi, J. Brahmer, S. Gettinger, D. Smith et al., Safety, Activity, and Immune Correlates of Anti???PD-1 Antibody in Cancer, New England Journal of Medicine, vol.366, issue.26, pp.2443-2454, 2012.
DOI : 10.1056/NEJMoa1200690

J. Taube, R. Anders, G. Young, H. Xu, R. Sharma et al., Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape, Science Translational Medicine, vol.4, issue.127, pp.127-137, 2012.
DOI : 10.1126/scitranslmed.3003689

D. Pardoll, Immunology beats cancer: a blueprint for successful translation, Nature Immunology, vol.11, issue.12, pp.1129-1132, 2012.
DOI : 10.1038/nm730

M. Mkrtichyan, Y. Najjar, E. Raulfs, M. Abdalla, R. Samara et al., Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms, European Journal of Immunology, vol.178, issue.10, pp.2977-2986, 2011.
DOI : 10.1002/eji.201141639

M. Mkrtichyan, Y. Najjar, E. Raulfs, L. Liu, S. Langerman et al., B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression Level on T Cell Subsets, The Journal of Immunology, vol.189, issue.5, pp.2338-2347, 2012.
DOI : 10.4049/jimmunol.1103085

R. Huang, J. Jalil, J. Economou, B. Chmielowski, R. Koya et al., CTLA4 Blockade Induces Frequent Tumor Infiltration by Activated Lymphocytes Regardless of Clinical Responses in Humans, Clinical Cancer Research, vol.17, issue.12, pp.4101-4109, 2011.
DOI : 10.1158/1078-0432.CCR-11-0407

D. Bellovin, B. Das, and D. Felsher, Tumor Dormancy, Oncogene Addiction, Cellular Senescence, and Self-Renewal Programs, Adv Exp Med Biol, vol.734, pp.91-107, 2013.
DOI : 10.1007/978-1-4614-1445-2_6

K. Rakhra, P. Bachireddy, T. Zabuawala, R. Zeiser, L. Xu et al., CD4+ T Cells Contribute to the Remodeling of the Microenvironment Required for Sustained Tumor Regression upon Oncogene Inactivation, Cancer Cell, vol.18, issue.5, pp.485-498, 2010.
DOI : 10.1016/j.ccr.2010.10.002

J. Deguine, B. Breart, F. Lemaître, and P. Bousso, Cutting Edge: Tumor-Targeting Antibodies Enhance NKG2D-Mediated NK Cell Cytotoxicity by Stabilizing NK Cell-Tumor Cell Interactions, The Journal of Immunology, vol.189, issue.12, pp.5493-5497, 2012.
DOI : 10.4049/jimmunol.1202065

J. Crespo, H. Sun, T. Welling, Z. Tian, and W. Zou, T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment, Current Opinion in Immunology, vol.25, issue.2, pp.952-791500193
DOI : 10.1016/j.coi.2012.12.003

S. Kerkar, P. Muranski, A. Kaiser, A. Boni, L. Sanchez-perez et al., Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts, Cancer Research, vol.70, issue.17, pp.6725-6734, 2010.
DOI : 10.1158/0008-5472.CAN-10-0735

S. Kerkar, R. Goldszmid, P. Muranski, D. Chinnasamy, Z. Yu et al., IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors, Journal of Clinical Investigation, vol.121, issue.12, pp.4746-4757, 2011.
DOI : 10.1172/JCI58814DS1

M. Jinushi, Y. Nakazaki, M. Dougan, D. Carrasco, M. Mihm et al., MFG-E8???mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF, Journal of Clinical Investigation, vol.117, issue.7, pp.1902-1913, 2007.
DOI : 10.1172/JCI30966DS1

M. Jinushi, M. Sato, A. Kanamoto, A. Itoh, S. Nagai et al., Milk fat globule epidermal growth factor???8 blockade triggers tumor destruction through coordinated cell-autonomous and immune-mediated mechanisms, The Journal of Experimental Medicine, vol.206, issue.6, pp.1317-1326, 2009.
DOI : 10.1073/pnas.90.8.3539

O. Ali, D. Emerich, G. Dranoff, and D. Mooney, In situ regulation of CD subsets and T cells mediates tumor regression in mice, Sci Transl Med, vol.1, pp.8-19, 2009.

M. Disis, T. Gooley, K. Rinn, D. Davis, M. Piepkorn et al., Generation of T-Cell Immunity to the HER-2/neu Protein After Active Immunization With HER-2/neu Peptide???Based Vaccines, Journal of Clinical Oncology, vol.20, issue.11, pp.2624-2632, 2002.
DOI : 10.1200/JCO.2002.06.171

M. Disis, D. Wallace, T. Gooley, Y. Dang, M. Slota et al., -Specific Vaccination in Patients With Metastatic Breast Cancer, Journal of Clinical Oncology, vol.27, issue.28, pp.4685-4692, 2009.
DOI : 10.1200/JCO.2008.20.6789

URL : https://hal.archives-ouvertes.fr/hal-01440327

J. Ko, A. Zea, B. Rini, J. Ireland, P. Elson et al., Sunitinib Mediates Reversal of Myeloid-Derived Suppressor Cell Accumulation in Renal Cell Carcinoma Patients, Clinical Cancer Research, vol.15, issue.6, pp.2148-2153, 2009.
DOI : 10.1158/1078-0432.CCR-08-1332

S. Walter, T. Weinschenk, A. Stenzl, R. Zdrojowy, A. Pluzanska et al., Multipeptide immune response to cancer vaccine IMA901 after single-dose cyclophosphamide associates with longer patient survival, Nature Medicine, vol.174, issue.8, pp.1254-1261, 2012.
DOI : 10.1016/j.cll.2007.05.002

P. Serafini, K. Meckel, M. Kelso, K. Noonan, J. Califano et al., Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function, The Journal of Experimental Medicine, vol.79, issue.12, pp.2691-2702, 2006.
DOI : 10.1073/pnas.90.8.3539

J. Fetting, N. Davidson, and E. Jaffee, Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocytemacrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation, J Clin Oncol, vol.27, pp.5911-5918, 2009.

I. Zlobec, K. Baker, L. Terracciano, S. Peter, L. Degen et al., Two-marker protein profile predicts poor prognosis in patients with early rectal cancer, British Journal of Cancer, vol.61, issue.10, pp.1712-1717, 2008.
DOI : 10.1158/1078-0432.CCR-08-0048

F. Pagès, A. Berger, M. Camus, F. Sanchez-cabo, A. Costes et al., Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer, New England Journal of Medicine, vol.353, issue.25, pp.2654-2666, 2005.
DOI : 10.1056/NEJMoa051424

I. Zlobec, P. Minoo, D. Baumhoer, K. Baker, L. Terracciano et al., Multimarker phenotype predicts adverse survival in patients with lymph node-negative colorectal cancer, Cancer, vol.52, issue.3, pp.495-502, 2008.
DOI : 10.1002/cncr.23208

W. Fridman, F. Pages, C. Sautes-fridman, and J. Galon, The immune contexture in human tumours: impact on clinical outcome, Nature Reviews Cancer, vol.29, issue.4, pp.298-306, 2012.
DOI : 10.1038/nrc3245

J. Galon, F. Pages, F. Marincola, M. Thurin, G. Trinchieri et al., The immunoscore as a new possible approach for the classification of cancer, J Transl Med, vol.3, pp.10-11, 2012.

J. Galon, P. Franck, F. Marincola, H. Angell, M. Thurin et al., Cancer classification using the Immunoscore: a worldwide task force, Journal of Translational Medicine, vol.10, issue.1, p.205, 2012.
DOI : 10.1186/1479-5876-10-1

URL : https://hal.archives-ouvertes.fr/inserm-00780742

S. Ugurel, D. Schrama, G. Keller, D. Schadendorf, E. Brocker et al., Impact of the CCR5 gene polymorphism on the survival of metastatic melanoma patients receiving immunotherapy, Cancer Immunology, Immunotherapy, vol.24, issue.5, pp.685-691, 2008.
DOI : 10.1007/s00262-007-0407-z

E. Wang, L. Uccellini, and F. Marincola, A genetic inference on cancer immune responsiveness, OncoImmunology, vol.19, issue.4, pp.520-525
DOI : 10.1007/s00262-007-0407-z