Abnormal binding and disruption in large scale networks involved in human partial seizures

Abstract : There is a marked increase in the amount of electrophysiological and neuroimaging works dealing with the study of large scale brain connectivity in the epileptic brain. Our view of the epileptogenic process in the brain has largely evolved over the last twenty years from the historical concept of "epileptic focus" to a more complex description of "Epileptogenic networks" involved in the genesis and "propagation" of epileptic activities. In particular, a large number of studies have been dedicated to the analysis of intracerebral EEG signals to characterize the dynamic of interactions between brain areas during temporal lobe seizures. These studies have reported that large scale functional connectivity is dramatically altered during seizures, particularly during temporal lobe seizure genesis and development. Dramatic changes in neural synchrony provoked by epileptic rhythms are also responsible for the production of ictal symptoms or changes in patient's behaviour such as automatisms, emotional changes or consciousness alteration. Beside these studies dedicated to seizures, large-scale network connectivity during the interictal state has also been investigated not only to define biomarkers of epileptogenicity but also to better understand the cognitive impairments observed between seizures.
Type de document :
Article dans une revue
EPJ Nonlinear Biomedical Physics, 2013, 1 (1), pp.4. 〈10.1140/epjnbp11〉
Liste complète des métadonnées

Littérature citée [72 références]  Voir  Masquer  Télécharger

Contributeur : Ed. Bmc <>
Soumis le : jeudi 27 juin 2013 - 13:03:34
Dernière modification le : mercredi 16 mai 2018 - 11:23:40


Fichiers éditeurs autorisés sur une archive ouverte




Fabrice Bartolomei, Maxime Guye, Fabrice Wendling. Abnormal binding and disruption in large scale networks involved in human partial seizures. EPJ Nonlinear Biomedical Physics, 2013, 1 (1), pp.4. 〈10.1140/epjnbp11〉. 〈inserm-00839181〉



Consultations de la notice


Téléchargements de fichiers