Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.

Abstract : Epithelial to mesenchymal transition (EMT) is a fundamental process during development and disease, including development of the heart valves and tumour metastases. An extended cellular Potts model was implemented to represent the behaviour emerging from autonomous cell morphology, labile adhesion, junctional coupling and cell motility. Computer simulations normally focus on these functional changes independently whereas this model facilitates exploration of the interplay between cell shape changes, adhesion and migration. The simulation model is fitted to an in vitro model of endocardial EMT, and agrees with the finding that Notch signalling increases cell-matrix adhesion in addition to modulating cell-cell adhesion.
Liste complète des métadonnées

Littérature citée [22 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00838163
Contributeur : Lotfi Senhadji <>
Soumis le : lundi 24 juin 2013 - 20:36:43
Dernière modification le : jeudi 26 juillet 2018 - 13:56:20
Document(s) archivé(s) le : mercredi 25 septembre 2013 - 04:12:07

Fichier

Abdulla_CMPB_Mar2013.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Tariq Abdulla, Jean-Marc Schleich, Ron Summers. Epithelial to mesenchymal transition-The roles of cell morphology, labile adhesion and junctional coupling.. Computer Methods and Programs in Biomedicine, Elsevier, 2013, 111 (2), pp.435-446. 〈10.1016/j.cmpb.2013.05.018〉. 〈inserm-00838163〉

Partager

Métriques

Consultations de la notice

549

Téléchargements de fichiers

383