Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Journal of Translational Medicine Année : 2013

Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer

Résumé

Epithelial ovarian cancer (EOC) is a significant cause of cancer-related mortality in women, and there has been no substantial decrease in the death rates due to EOC in the last three decades. Thus, basic knowledge regarding ovarian tumor cell biology is urgently needed to allow the development of innovative treatments for EOC. Traditionally, EOC has not been considered an immunogenic tumor, but there is evidence of an immune response to EOC in patients. Clinical data demonstrate that an antitumor immune response and immune evasion mechanisms are correlated with a better and lower survival, respectively, providing evidence for the immunoediting hypothesis in EOC. This review focuses on the immune response and immune suppression in EOC. The immunological roles of chemotherapy and surgery in EOC are also described. Finally, we detail pilot data supporting the efficiency of immunotherapy in the treatment of EOC and the emerging concept that immunomodulation aimed at counteracting the immunosuppressive microenvironment must be associated with immunotherapy strategies.
Fichier principal
Vignette du fichier
1479-5876-11-147.pdf (380.53 Ko) Télécharger le fichier
1479-5876-11-147.xml (176.23 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00834422 , version 1 (15-06-2013)

Identifiants

Citer

Vincent Lavoué, Aurélie Thédrez, Jean Levêque, Fabrice Foucher, Sébastien Henno, et al.. Immunity of human epithelial ovarian carcinoma: the paradigm of immune suppression in cancer. Journal of Translational Medicine, 2013, 11 (1), pp.147. ⟨10.1186/1479-5876-11-147⟩. ⟨inserm-00834422⟩
132 Consultations
498 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More