Is extracapsular tumour spread a prognostic factor in patients with early breast cancer?

Abstract : BACKGROUND: This study searched for extra capsular tumour spread (ECS) as a prognostic factor for recurrence in terms of Disease Free Survival (DFS) and Overall Survival (OS). PATIENTS AND METHODS: For this study, from a retrospective database of the Doubs cancer registry, 823 eligible women with node positive breast cancer treated from February 1984 to November 2000 were identified. The following factors were evaluated: ECS, numbers of involved nodes, histological tumour grade, tumour size, status of estrogen and progesterone receptors, and age of patient. A Cox proportional hazards method was used to search for significant factors related to OS and DFS length. RESULTS: In the multivariate analysis, factors related to DFS length were found to be: tumour grade (aHR 0.76, 95 % CI 0.61-0.96, p = 0.02), ECS status (aHR 0.7, 95 % CI 0.49-0.96, p = 0.03), progesterone (PgR) status (aHR 0.63, 95 % CI 0.44-0.85 p = 0.008), number of nodes involved (aHR 0.75, 95 % CI 0.56-1, p = 0.05). The multivariate analysis for OS found as significant factors: tumour grade (aHR 0.76, 95 % CI 0.61-0.95; p = 0.02) and PgR status (aHR 0.8, 95 % CI 0.56-0.99, p = 0.02). CONCLUSIONS: This study might suggest taking into account ECS status in the adjuvant decision-making process.
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International Journal of Clinical Oncology, Springer Verlag, 2012, epub ahead of print. 〈10.1007/s10147-012-0439-z〉
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Soumis le : vendredi 10 mai 2013 - 15:49:32
Dernière modification le : jeudi 15 février 2018 - 08:48:14

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Erion Dobi, Fernando Bazan, Armelle Dufresne, Martin Demarchi, Cristian Villanueva, et al.. Is extracapsular tumour spread a prognostic factor in patients with early breast cancer?. International Journal of Clinical Oncology, Springer Verlag, 2012, epub ahead of print. 〈10.1007/s10147-012-0439-z〉. 〈inserm-00821517〉

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