mTOR signaling at a glance, Journal of Cell Science, vol.122, issue.20, pp.3589-3594, 2009. ,
DOI : 10.1242/jcs.051011
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1, Human Molecular Genetics, vol.17, issue.19, pp.2934-2948, 2008. ,
DOI : 10.1093/hmg/ddn192
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB, Molecular Cell, vol.22, issue.2, pp.159-168, 2006. ,
DOI : 10.1016/j.molcel.2006.03.029
URL : http://doi.org/10.1016/j.molcel.2006.03.029
The mTORC2 Complex Regulates Terminal Differentiation of C2C12 Myoblasts, Molecular and Cellular Biology, vol.29, issue.17, pp.4691-4700, 2009. ,
DOI : 10.1128/MCB.00764-09
mTOR signaling: PLD takes center stage, Cell Cycle, vol.7, issue.20, pp.3118-3123, 2008. ,
DOI : 10.4161/cc.7.20.6881
Phosphatidic acid signaling to mTOR: Signals for the survival of human cancer cells, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1791, issue.9, pp.949-955, 2009. ,
DOI : 10.1016/j.bbalip.2009.02.009
Emerging findings from studies of phospholipase D in model organisms (and a short update on phosphatidic acid effectors), Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1791, issue.9, pp.889-897, 2009. ,
DOI : 10.1016/j.bbalip.2009.03.013
Regulation of mTORC1 and mTORC2 Complex Assembly by Phosphatidic Acid: Competition with Rapamycin, Molecular and Cellular Biology, vol.29, issue.6, pp.1411-1420, 2009. ,
DOI : 10.1128/MCB.00782-08
Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR, Oncogene, vol.28, issue.5, pp.585-595, 2008. ,
DOI : 10.1038/ncb1594
The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle, Proceedings of the National Academy of Sciences, vol.103, issue.12, pp.4741-4746, 2006. ,
DOI : 10.1073/pnas.0600678103
Resistance Exercise Increases Muscle Protein Synthesis and Translation of Eukaryotic Initiation Factor 2B?? mRNA in a Mammalian Target of Rapamycin-dependent Manner, Journal of Biological Chemistry, vol.280, issue.9, pp.7570-7580, 2005. ,
DOI : 10.1074/jbc.M413732200
Atrophy of S6K1???/??? skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control, Nature Cell Biology, vol.279, issue.3, pp.286-294, 2005. ,
DOI : 10.1093/emboj/17.22.6649
mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms, AJP: Cell Physiology, vol.297, issue.6, pp.1434-1444, 2009. ,
DOI : 10.1152/ajpcell.00248.2009
The Mitogenic and Myogenic Actions of Insulin-like Growth Factors Utilize Distinct Signaling Pathways, Journal of Biological Chemistry, vol.272, issue.10, pp.6653-6662, 1997. ,
DOI : 10.1074/jbc.272.10.6653
Stress-activated Protein Kinase-2/p38 and a Rapamycin-sensitive Pathway Are Required for C2C12 Myogenesis, Journal of Biological Chemistry, vol.274, issue.7, pp.4341-4346, 1999. ,
DOI : 10.1074/jbc.274.7.4341
The Mammalian Target of Rapamycin Regulates C2C12 Myogenesis via a Kinase-independent Mechanism, Journal of Biological Chemistry, vol.276, issue.39, pp.36079-36082, 2001. ,
DOI : 10.1074/jbc.C100406200
Myogenic Differentiation Is Dependent on Both the Kinase Function and the N-terminal Sequence of Mammalian Target of Rapamycin, Journal of Biological Chemistry, vol.277, issue.19, pp.16726-16732, 2002. ,
DOI : 10.1074/jbc.M112285200
Presence of Functional Oxytocin Receptors in Cultured Human Myoblasts, The Journal of Clinical Endocrinology & Metabolism, vol.87, issue.3, pp.1415-1418, 2002. ,
DOI : 10.1210/jcem.87.3.8537
Phorbol ester-induced differentiation of L6 myogenic cells involves phospholipase D activation, FEBS Letters, vol.482, issue.3, pp.409-414, 2004. ,
DOI : 10.1016/j.febslet.2004.10.036
Phospholipase D Is Involved in Myogenic Differentiation through Remodeling of Actin Cytoskeleton, Molecular Biology of the Cell, vol.16, issue.3, pp.1232-1244, 2005. ,
DOI : 10.1091/mbc.E04-06-0459
Inhibition of de novo ceramide synthesis upregulates phospholipase D and enhances myogenic differentiation, Journal of Cell Science, vol.120, issue.3, pp.407-416, 2007. ,
DOI : 10.1242/jcs.03331
URL : https://hal.archives-ouvertes.fr/inserm-00276757
PLD regulates myoblast differentiation through the mTOR-IGF2 pathway, Journal of Cell Science, vol.121, issue.3, pp.282-289, 2008. ,
DOI : 10.1242/jcs.022566
Optimization of Halopemide for Phospholipase D2 inhibition, Bioorganic & Medicinal Chemistry Letters, vol.17, issue.8, pp.2310-2311, 2007. ,
DOI : 10.1016/j.bmcl.2007.01.059
5-Fluoro-2-indolyl des-chlorohalopemide (FIPI), a Phospholipase D Pharmacological Inhibitor That Alters Cell Spreading and Inhibits Chemotaxis, Molecular Pharmacology, vol.75, issue.3, pp.437-446, 2009. ,
DOI : 10.1124/mol.108.053298
Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness, Nature Chemical Biology, vol.275, issue.2, pp.108-117, 2009. ,
DOI : 10.1038/nchembio.140
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling, Molecular and Cellular Biology, vol.30, issue.4, pp.908-921, 2010. ,
DOI : 10.1128/MCB.00601-09
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815569
Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1, Molecular and Cellular Biology, vol.29, issue.21, pp.5657-5670, 2009. ,
DOI : 10.1128/MCB.00735-09
PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding, Journal of Biological Chemistry, vol.282, issue.27, pp.20036-20044, 2007. ,
DOI : 10.1074/jbc.M702376200
Inhibition profiles of phosphatidylinositol 3-kinase inhibitors against PI3K superfamily and human cancer cell line panel JFCR39, European Journal of Cancer, vol.46, issue.6, pp.1111-1121, 2010. ,
DOI : 10.1016/j.ejca.2010.01.005
Structure, Sequence, Expression, and Chromosomal Localization of the Human V1aVasopressin Receptor Gene, Genomics, vol.31, issue.3, pp.327-334, 1996. ,
DOI : 10.1006/geno.1996.0055
Nutrient-dependent Multimerization of the Mammalian Target of Rapamycin through the N-terminal HEAT Repeat Region, Journal of Biological Chemistry, vol.281, issue.39, pp.28605-28614, 2006. ,
DOI : 10.1074/jbc.M606087200
Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway, FEBS Letters, vol.283, issue.6, pp.965-970, 2009. ,
DOI : 10.1016/j.febslet.2009.02.015
Syndecan-4 Regulates Subcellular Localization of mTOR Complex2 and Akt Activation in a PKC??-Dependent Manner in Endothelial Cells, Molecular Cell, vol.32, issue.1, pp.140-149, 2008. ,
DOI : 10.1016/j.molcel.2008.09.010
Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini., Molecular and Cellular Biology, vol.11, issue.11, pp.5541-5550, 1991. ,
DOI : 10.1128/MCB.11.11.5541
Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR, The FASEB Journal, vol.21, issue.4, pp.1075-1087, 2007. ,
DOI : 10.1096/fj.06-6652com
Differential Activation of p70 and p85 S6 Kinase Isoforms during Cardiac Hypertrophy in the Adult Mammal, Journal of Biological Chemistry, vol.273, issue.38, pp.24610-24619, 1998. ,
DOI : 10.1074/jbc.273.38.24610
Thyroid Hormone Stimulates Protein Synthesis in the Cardiomyocyte by Activating the Akt-mTOR and p70S6K Pathways, Journal of Biological Chemistry, vol.281, issue.30, pp.20666-20672, 2006. ,
DOI : 10.1074/jbc.M512671200
L6 myoblast differentiation is modulated by Cdk5 via the PI3K???AKT???p70S6K signaling pathway, Oncogene, vol.23, issue.36, pp.6064-6070, 2004. ,
DOI : 10.1038/sj.onc.1207819
Mammalian Target of Rapamycin (mTOR) Signaling Is Required for a Late-stage Fusion Process during Skeletal Myotube Maturation, Journal of Biological Chemistry, vol.280, issue.36, pp.32009-32017, 2005. ,
DOI : 10.1074/jbc.M506120200
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size, AJP: Cell Physiology, vol.296, issue.6, pp.1258-1270, 2009. ,
DOI : 10.1152/ajpcell.00105.2009
Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors, Cancer Research, vol.69, issue.15, pp.6107-6114, 2009. ,
DOI : 10.1158/0008-5472.CAN-09-0975
FKHR (FOXO1a) is required for myotube fusion of primary mouse myoblasts, The EMBO Journal, vol.22, issue.5, pp.1147-1157, 2003. ,
DOI : 10.1093/emboj/cdg116
Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton, Current Biology, vol.14, issue.14, pp.1296-1302, 2004. ,
DOI : 10.1016/j.cub.2004.06.054
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling, The EMBO Journal, vol.9, issue.14, pp.1919-1931, 2008. ,
DOI : 10.1038/emboj.2008.119
Mechanisms of Regulation of Phospholipase D1 by Protein Kinase Calpha, Journal of Biological Chemistry, vol.278, issue.4, pp.2348-2355, 2003. ,
DOI : 10.1074/jbc.M210093200
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive, Nature Cell Biology, vol.59, issue.11, pp.1122-1128, 2004. ,
DOI : 10.1006/jmbi.2000.4042