Lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium-90 glass microsphere radioembolization: preliminary results.

Abstract : Portal vein tumor thrombosis (PVTT) is a common complication of hepatocellular carcinoma (HCC) and has a negative impact on prognosis. This characteristic feature led to the rationale of the present trial designed to assess the efficacy and the safety of yttrium-90 glass-microsphere treatment for advanced-stage lobar HCC with ipsilateral PVTT. 18 patients with unresectable lobar HCC and ipsilateral PVTT were treated in our institution with (90)Y-microS radioembolization. Patients were evaluated every 3 to 6 months for response, survival, and toxicity. Mean follow-up was 13.0 months (2.2-50.6). Outcomes were: complete response (n = 2), partial response (n = 13), stable disease (n = 1), and progressive disease (n = 2) giving a disease control rate of 88.9%. Four patients were downstaged. Treating lobar hepatocellular carcinoma with ipsilateral portal vein thrombosis with yttrium-90 glass-microsphere radioembolization is safe and efficacious. Further clinical trials are warranted to confirm these results and to compare (90)Y-microS with sorafenib, taking into account not only survival but also the possibility of secondary surgery for putative curative intention after downstaging.
Type de document :
Article dans une revue
International Journal of Hepatology, 2013, 2013, pp.827649. 〈10.1155/2013/827649〉
Liste complète des métadonnées

Littérature citée [32 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00814189
Contributeur : Véronique Touya <>
Soumis le : mardi 23 avril 2013 - 10:22:18
Dernière modification le : mercredi 16 mai 2018 - 11:24:09
Document(s) archivé(s) le : jeudi 25 juillet 2013 - 11:20:23

Fichier

827649.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Citation

Marc Pracht, Julien Edeline, Laurence Lenoir, M. Latournerie, Habiba Mesbah, et al.. Lobar hepatocellular carcinoma with ipsilateral portal vein tumor thrombosis treated with yttrium-90 glass microsphere radioembolization: preliminary results.. International Journal of Hepatology, 2013, 2013, pp.827649. 〈10.1155/2013/827649〉. 〈inserm-00814189〉

Partager

Métriques

Consultations de la notice

411

Téléchargements de fichiers

204