Social stress models in depression research: what do they tell us?

Abstract : Interest has recently surged in the use of social stress models, especially social defeat. Such interest lies both in the recognition that stressors of social origin play a major role in human psychopathologies and in the acknowledgement that natural and hence ethologically-based stress models have important translational value. The use of the most recent technology has allowed the recognition of the mechanisms through which social defeat might have enduring psychoneuroendocrine effects, especially social avoidance and anhedonia, two behaviours relevant to human depression. In view of the sensitivity of these behavioural outcomes to repeated antidepressant treatments, the social defeat model has been proposed as a possible animal model of depression. The present survey is aimed at examining the limits of such an interpretation and focuses on methodological aspects and on the relevance of social defeat to the study of anxiety-related pathologies.
Type de document :
Article dans une revue
Cell and Tissue Research, Springer Verlag, 2013, epub ahead of print. 〈10.1007/s00441-013-1606-x〉
Liste complète des métadonnées

Littérature citée [106 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00813556
Contributeur : Francis Chaouloff <>
Soumis le : mardi 15 avril 2014 - 07:00:05
Dernière modification le : mercredi 29 novembre 2017 - 14:54:07
Document(s) archivé(s) le : mardi 15 juillet 2014 - 10:37:03

Fichiers

Review_Chaouloff_CTR_13_0012_R...
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

Citation

Francis Chaouloff. Social stress models in depression research: what do they tell us?. Cell and Tissue Research, Springer Verlag, 2013, epub ahead of print. 〈10.1007/s00441-013-1606-x〉. 〈inserm-00813556〉

Partager

Métriques

Consultations de la notice

251

Téléchargements de fichiers

311