S. Ta-rui and Y. Matsuzawa, Contribution of visceral fat accumulation to the de-velopment of coronary artery disease in non-obese men

V. Solfrizzi, F. Panza, V. Frisardi, D. Seripa, G. Logroscino et al., Diet and Alzheimer???s disease risk factors or prevention: the current evidence, Expert Review of Neurotherapeutics, vol.11, issue.5, pp.677-708, 2011.
DOI : 10.1586/ern.11.56

B. Vessby, S. Chen, and R. Chen, Dietary fat, fatty acid composition in plasma and the metabolic syndrome Docosahexaenoic acid-containing phospholipids and triglycerides based nutritional supplements, Curr. Opin. Lipidol. Recent Pat. Food. Nutr. Agric, vol.14, issue.2, pp.15-19, 2003.

A. M. Giudetti, R. Cagnazzo, L. L. Souza, and L. C. Faustino, Beneficial effects of n-3 PUFA on chronic airway inflammatory diseases, Prostaglandins & Other Lipid Mediators, vol.99, issue.3-4, pp.57-67, 2008.
DOI : 10.1016/j.prostaglandins.2012.09.006

T. M. Ortiga-carvalho, K. J. Oliveira, and C. C. Pazos-moura, Thyroid hormone contributes to hypolipidemic effect of polyunsaturated fatty acids from fish oil: in vivo evidence for cross talking mechanisms, J. Endocrinol, vol.2119, pp.65-72, 2011.

D. Caterina, R. Madonna, R. Bertolotto, A. Schmidt, and E. B. , n-3 Fatty Acids in the Treatment of Diabetic Patients: Biological rationale and clinical data, Diabetes Care, vol.30, issue.4, pp.1012-1026, 2007.
DOI : 10.2337/dc06-1332

D. Mozaffarian, J. Wu, P. A. Corsetto, G. Montorfano, S. Zava et al., Omega-3 fatty acids and cardiovascular disease Effects of n-3 PUFA on breast cancer cells through their incorporation in plasma membranes, J.Am. Coll. Cardiol. Lipids Health Dis, vol.5213, issue.12, pp.2578-258510, 2003.

Z. Guo, A. F. Vikbjerg, and X. B. Xu, Enzymatic modification of phospholipids for functional applications and human nutrition, Biotechnology Advances, vol.23, issue.3, pp.203-259, 2005.
DOI : 10.1016/j.biotechadv.2005.02.001

S. D. Doig and R. M. Diks, Toolbox for exchanging constituent fatty acids in lecithin [15] Timmermann, F. Functional food and lipids. Oils Fats, Medium chain triglycerides and structured lipids, pp.359-367, 1987.

R. Trivedi and R. P. Singh, Modification of Oils and Fats to Produce Structured Lipids, Journal of Oleo Science, vol.54, issue.8, pp.423-430, 2005.
DOI : 10.5650/jos.54.423

A. G. Marangoni, D. Rousseau, and G. G. Haraldsson, Chemical interesterification. Food Lipids The application of lipases for preparing various lipids enriched with omega-3 fatty acids Almarsson, O. Studies on the positional specificity of lipase from Mucor miehei during interesterification reactions of cod liver oil with n-3 polyunsaturated fatty acid and ethyl ester concentrates, Rit. Fiskideildar. Acta Chem. Scand, vol.1621, issue.45, pp.251-281, 1991.

K. H. Huang, C. Akoh, C. C. Akoh, and C. Moussata, Optimization and scale-up of enzymatic synthesis of structured lipids using RSM Characterization and oxidative stability of enzymatically produced fish and canola-oil-based structured lipids, J. Food Sci. J. Am. Oil Chem. Soc, vol.6123, issue.78, pp.137-141, 1996.

B. Jennings, C. C. Akoh, and A. Kawashima, Enzymatic modification of triacylglycerols of high eicosapentaenoic and docosahexaenoic acids content to produce structured lipids, Journal of the American Oil Chemists??? Society, vol.45, issue.10, pp.1133-1137, 1999.
DOI : 10.1007/s11746-999-0085-4

S. Komemushi and Y. Tominaga, Enzymatic synthesis of high-purity structured lipids with caprylic acid at 1,3-positions and polyunsaturated fatty acid at 2- position, J. Am. Oil Chem. Soc, vol.7825, pp.611-616, 2001.

Y. Iwasaki, J. J. Han, M. Narita, R. Rosu, and T. Yamane, Enzymatic synthesis of structured lipids from single cell oil of high docosahexaenoic acid content, Journal of the American Oil Chemists' Society, vol.70, issue.5, pp.563-669, 1999.
DOI : 10.1007/s11746-999-0005-7

Y. Shimada, A. Sugihara, T. Maruyama, T. Nagao, H. Nakayama et al., Production of structured lipid containing docosahexaenoic and caprylic acids using immobilized Rhizopus delemar lipase, Journal of Fermentation and Bioengineering, vol.81, issue.4, pp.299-303, 1996.
DOI : 10.1016/0922-338X(96)80580-0

X. Xu, A. Skands, and G. Jonsson, Production of structured lipids by lipase-catalysed interesterification in an ultrafiltration membrane reactor, Biotech-nology. Letters, vol.2229, pp.1667-1671, 2000.

H. Garcia, J. Arcos, D. Ward, C. Hill, R. Irimescu et al., Synthesis of glycerides containing n- 3 fatty acids and conjugated linoleic acid by solvent-free acidolysis of fish oil Utilization of reaction medium-dependent regiospecificity of Candida antarctica lipase (Novozym 435) for the synthesis of 1,3-dicapryloyl-2-docosahexaenoyl. (or eicosapentaenoyl) glycerol Two-step enzymatic synthesis of docosahexaenoic acid-rich symmetrically structured triacylglycerols via 2-monoacylglycerols Synthesis of structured lipids by two enzymatic steps: Ethanolysis of fish oils and esterifi-cation of 2-monoacylglycerols, Biotechnol. Bioeng. J. Am. Oil Chem. Soc. J. Am Oil Chem. Soc. Process Biochemistry B, vol.30, issue.44, pp.587-591, 2000.

P. A. González and A. Robles, Synthesis of 2-monoacylglycerols and structured triacylglycerols rich in polyunsaturated fatty acids by enzyme catalyzed reactions, Enzyme Microb. Technol, vol.5134, pp.148-155, 2012.

H. Zhang, G. Önal, C. Wijesundera, and X. Xu, Practical synthesis of 1,3-oleoyl 2-docosahexaenoyl-glycerol by lipase-catalyzed reactions: An evaluation of different reaction routes, Process. Biochemistry, vol.4435, pp.534-539, 2009.

Y. Endo, S. Hoshizaki, K. Fujimoto, A. Haldorsson, C. Magnusson et al., Oxidation of synthetic triacylglycerols containing eicosa-pentaenoic and docosahexaenoic acids: Effect of oxidation system and triacylglycerol structure Chemoenzymatic synthesis of structured triacylglycerols Chemoenzymatic synthesis of structured triacylglycerols Chemoenzymatic synthesis of structured triacylglycerols possessing short-chain fatty acids Practical syntheses of triacylglycerol regioisomers containing long-chain polyunsaturated fatty acids, J. Am. Oil.Chem. Soc. Tetrahedron. Lett. Tetrahedron Tetrahedron P J. Amer. Oil. Chem. Soc, vol.7440, issue.84, pp.1041-1045, 1997.

C. D. Magnusson and G. G. Haraldsson, Activation of n-3 polyunsaturated fatty acids as oxime esters: a novel approach for their exclusive incorporation into the primary alcoholic positions of the glycerol moiety by lipase, Chemistry and Physics of Lipids, vol.165, issue.7, pp.712-720, 2012.
DOI : 10.1016/j.chemphyslip.2012.07.005

B. Chen, H. Zhang, L. Z. Cheong, T. Tan, X. Xu et al., Enzymatic Production of ABA-Type Structured Lipids Containing Omega-3 and Medium-Chain Fatty Acids: Effects of Different Acyl Donors on the Acyl Migration Rate, Food and Bioprocess Technology, vol.71, issue.2, pp.541-547, 2004.
DOI : 10.1007/s11947-009-0322-8

A. Seto, J. Jelinek, T. Reinecker, A. Hauenschild, G. Boehm et al., Short term effects of dietary medium-chain fatty acids and n-3 long-chain polyunsaturated fatty acids on the fat metabolism of healthy volun-teers Consumption of a functional oil rich in phytosterols and medium-chain triglyceride oil im-proves plasma lipid profile in men Physiological functions of iso-type short-chain fatty acid and omega 3 polyunsaturated fatty acids containing oil in obese OLETF rats Oxidative stability of docosahexaenoic acid-containing oils in the form of phospholipids, triacylglycerols and ethyl esters, 49] Lyberg, A.M.; Fasoli, E.; Adlercreutz, P. Monitoring the oxidation of docosahexaenoic acid in lipids. Lipids, pp.1293-1298, 1996.

B. Stankova, B. Kristinsson, G. G. Haraldsson, H. Svensen, I. Stoknes et al., Metabolic effects of n-3 PUFA as phospholipids are superior to triglycerides in mice fed a high-fat diet: possible role of endocannabinoids Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF, -13. [51] Vigerust, 2012.

M. Armstrong and M. Lagarde, Blood compartmental metabolism of docosahexaenoic acid (DHA) in humans after ingestion of a single dose of [ 13 C]DHA in phosphatidylcholine, J. Lipid. Res, vol.40, pp.1867-1874, 1999.

J. T. Brenna, P. Pillon, P. Moliere, M. Lagarde, and J. Lecerf, Efficacy of dietary arachidonic acid provided as triglyceride or phospholipid as substrates for brain arachidonic acid accretion in baboon neonates Preferential incorporation of sn-2 lysoPC DHA over unesterified DHA in the young rat brain, Pediatr. Res. Am. J. Physiol, vol.5155, pp.265-272, 1994.

N. Bernoud, L. Fenart, P. Moliere, M. P. Dehouck, M. Lagarde et al., Preferential Transfer of 2-Docosahexaenoyl-1-Lysophosphatidylcholine Through an In Vitro Blood-Brain Barrier Over Unesterified Docosahexaenoic Acid, Journal of Neurochemistry, vol.28, issue.1, pp.338-345, 1999.
DOI : 10.1046/j.1471-4159.1999.0720338.x

URL : https://hal.archives-ouvertes.fr/hal-00524636

M. Jim, N. Hung, J. Yoo, M. Kim, and D. Sok, Suppressive effect of docosahexaenoyl-lysophosphatidylcholine and 17- hydroxydocosahexaenoyl-lysophosphatidylcholine on levels of cytokines in spleen of mice treated with lipopolysaccharide Preparation of phospholipids highly enriched with n-3 polyunsaturated fatty acids by lipase, Eur. J .Lipid Sci. Technol. J. Am. Oil Chem. Soc, vol.11458, issue.76, pp.114-122, 1999.

L. Poisson, M. Devos, S. Godet, F. Ergan, and G. Pencreac-'h, Acyl migration during deacylation of phospholipids rich in docosahexaenoic acid (DHA): an enzymatic approach for evidence and study, Biotechnology Letters, vol.92, issue.5, pp.31-743, 2009.
DOI : 10.1007/s10529-009-9932-5

M. Croset, N. Brossard, A. Polette, and M. Lagarde, Caracterization of plasma unsaturated lysophosphatidylcholine in human and rat Enzymatic fatty acid exchange in glycero-phospholipids, Biochem. J. Eur. J. Lipid Sci. Technol, vol.345, issue.105, pp.61-67, 2000.

T. Tanaka, T. Isezaki, H. Nakano, and Y. Iwasaki, Synthesis of phospholipids containing polyunsaturated fatty acids by phospholipase A2-mediated esterification with food-compatible reagents Enzymatic and chemical synthesis of phosphatidylcholine regioisomers containing eicosapentaenoic acid or docosahexaenoic acid, J. Oleo. Sci. Eur J Lipid Sci. Technol, vol.5963, issue.107, pp.375-380, 2005.

I. H. Kim, H. Garcia, and C. Graham-hill, Phospholipase A1-catalyzed synthesis of phospholipids enriched in n -3 polyunsaturated fatty acid residues Enz, Microb. Technol, vol.4064, pp.1130-1135, 2007.

J. Baeza-jiménez, H. Noriega-rodríguez, H. García, and C. Otero, Structured phosphatidylcholine with elevated content of conjugated linoleic acid: Optimization by response surface methodology X. Synthesis of structured phospholipids by immobilized phos-pholipase A2-catalyzed acidolysis, Eur. J. Lipid Sci. Technol. J. Biotechnol, vol.11466, issue.128, pp.1261-1267, 2007.

M. Lagarde, Synthesis of acetyl,docosahexaenoyl-glycerophosphocholine and its characterization using nuclear magnetic resonance, Lipids, vol.3467, pp.1333-1370, 1999.

M. Lagarde, M. Guichardant, M. Picq, S. Michaud, and A. Doutheau, Method for preparing acetyl,docosahexaenoyl-glycerophosphocholine and use thereof for the delivery of polyunsaturated fatty acids. WIPO Patent Application WO, 2008.

J. M. Maligan, T. Estiasih, J. Kusnadi, and P. Aguettaz, Structured phospholipids from commercial soybean lecithin containing omega-3 fatty acids reduces atherosclerosis risk in male Sprague dawley rats which fed with an atherogenic diet. World academy of science, Engineering and technology, pp.552-558, 2012.

M. Picq, M. Lagarde, Y. Berthezene, N. Nighoghossian, M. Wiart et al., Braintargeting form of docosahexaenoic acid for experimental stroke treatment: MRI evaluation and anti-oxidant impact Synthesis of a novel phosphatidylcholine conjugated to docosahexaenoic acid and methotrexate that inhibits cell proliferation. Anti-Cancer Drugs, Lysophosphatidylcholine containing docosahexaenoic acid at the sn-1 position is anti-inflammatory, pp.95-102, 2002.

C. N. Serhan and N. Petasis, Resolvins and Protectins in Inflammation Resolution, Chemical Reviews, vol.111, issue.10, pp.5922-5943, 2009.
DOI : 10.1021/cr100396c