R. Hruban, M. Goggins, J. Parsons, and S. Kern, Progression model for pancreatic cancer, Clin Cancer Res, vol.6, pp.2969-2972, 2000.

R. Hruban, A. Maitra, S. Kern, and M. Goggins, Precursors to Pancreatic Cancer, Gastroenterology Clinics of North America, vol.36, issue.4, pp.831-849, 2007.
DOI : 10.1016/j.gtc.2007.08.012

N. Jonckheere, N. Skrypek, and I. Van-seuningen, Mucins and Pancreatic Cancer, Cancers, vol.2, issue.4, pp.1794-1812, 2010.
DOI : 10.3390/cancers2041794
URL : https://hal.archives-ouvertes.fr/inserm-00807873

N. Jonckheere and I. Van-seuningen, The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies, Critical Reviews??? in Oncogenesis, vol.14, issue.2-3, pp.177-196, 2008.
DOI : 10.1615/CritRevOncog.v14.i2-3.30

M. Komoto, B. Nakata, R. Amano, N. Yamada, and M. Yashiro, HER2 overexpression correlates with survival after curative resection of pancreatic cancer, Cancer Science, vol.355, issue.7, pp.1243-1247, 2009.
DOI : 10.1111/j.1349-7006.2009.01176.x

I. Van-seuningen, E. Leteurtre, and P. Pigny, Mucins in pancreas and hepatobiliary tract. Expression, regulation, biomarkers and therapy, The Epithelial Mucins: Structure/Function Roles in Cancer and Inflammatory Diseases. Kerala, India: Research Signpost, pp.233-248, 2008.

N. Moniaux, S. Nollet, N. Porchet, P. Degand, and A. Laine, Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin, Biochemical Journal, vol.338, issue.2, pp.325-333, 1999.
DOI : 10.1042/bj3380325

S. Nollet, N. Moniaux, M. J. Petitprez, D. Degand, and P. , Human mucin gene MUC4: organization of its 5???-region and polymorphism of its central tandem repeat array, Biochemical Journal, vol.332, issue.3, pp.739-748, 1998.
DOI : 10.1042/bj3320739

N. Porchet, V. Nguyen, J. Dufosse, J. Audie, and V. Guyonnet-duperat, Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs, Biochemical and Biophysical Research Communications, vol.175, issue.2, pp.414-422, 1991.
DOI : 10.1016/0006-291X(91)91580-6

N. Jonckheere and I. Van-seuningen, The ever growing family of membranebound mucins In: Van Seuningen I, ed. The Epithelial Mucins: Structure/ Function Roles in Cancer and Inflammatory Diseases, pp.17-38, 2008.

J. Desseyn, I. Clavereau, and A. Laine, Cloning, chromosomal localization and characterization of the murine mucin gene orthologous to human MUC4, 2002.

K. Carraway, G. Theodoropoulos, G. Kozloski, C. Carraway, and C. , Muc4/MUC4 functions and regulation in cancer, Future Oncology, vol.5, issue.10, pp.1631-1640, 2009.
DOI : 10.2217/fon.09.125

K. Carraway, V. Ramsauer, B. Haq, C. Carraway, and C. , Cell signaling through membrane mucins, BioEssays, vol.2, issue.1, pp.66-71, 2003.
DOI : 10.1002/bies.10201

M. Moasser, The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis, Oncogene, vol.15, issue.45, pp.6469-6487, 2007.
DOI : 10.1158/1078-0432.CCR-04-0112

P. Chaturvedi, A. Singh, S. Chakraborty, S. Chauhan, and S. Bafna, MUC4 Mucin Interacts with and Stabilizes the HER2 Oncoprotein in Human Pancreatic Cancer Cells, Cancer Research, vol.68, issue.7, pp.2065-2070, 2008.
DOI : 10.1158/0008-5472.CAN-07-6041

N. Moniaux, P. Chaturvedi, G. Varshney, J. Meza, and J. Rodriguez-sierra, Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells, British Journal of Cancer, vol.265, issue.3, pp.345-357, 2007.
DOI : 10.1093/nar/30.4.e15

K. Pirollo, A. Rait, Q. Zhou, S. Hwang, and J. Dagata, Materializing the Potential of Small Interfering RNA via a Tumor-Targeting Nanodelivery System, Cancer Research, vol.67, issue.7, pp.2938-2943, 2007.
DOI : 10.1158/0008-5472.CAN-06-4535

G. Theodoropoulos, C. Carraway, and K. Carraway, MUC4 involvement in ErbB2/ErbB3 phosphorylation and signaling in response to airway cell mechanical injury, Journal of Cellular Biochemistry, vol.38, issue.381, pp.112-122, 2009.
DOI : 10.1002/jcb.22106

V. Ramsauer, C. Carraway, P. Salas, and K. Carraway, Muc4/Sialomucin Complex, the Intramembrane ErbB2 Ligand, Translocates ErbB2 to the Apical Surface in Polarized Epithelial Cells, Journal of Biological Chemistry, vol.278, issue.32, pp.30142-30147, 2003.
DOI : 10.1074/jbc.M303220200

N. Jonckheere, M. Perrais, C. Mariette, S. Batra, and J. Aubert, A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-?? in pancreatic carcinogenesis, Oncogene, vol.23, issue.34, pp.5729-5738, 2004.
DOI : 10.1038/sj.onc.1207769

I. Van-seuningen, J. Ostrowski, X. Bustelo, P. Sleath, and K. Bomsztyk, The K Protein Domain That Recruits the Interleukin 1-responsive K Protein Kinase Lies Adjacent to a Cluster of c-Src and Vav SH3-binding Sites: IMPLICATIONS THAT K PROTEIN ACTS AS A DOCKING PLATFORM, Journal of Biological Chemistry, vol.270, issue.45, pp.26976-26985, 1995.
DOI : 10.1074/jbc.270.45.26976

N. Jonckheere, V. Fauquette, L. Stechly, N. Saint-laurent, and S. Aubert, Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2?? overexpression, British Journal of Cancer, vol.7, issue.4, pp.637-644, 2009.
DOI : 10.1158/0008-5472.CAN-07-5953
URL : https://hal.archives-ouvertes.fr/inserm-00410436

G. Piessen, N. Jonckheere, A. Vincent, B. Hemon, and M. Ducourouble, Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1??, Biochemical Journal, vol.402, issue.1, pp.81-91, 2007.
DOI : 10.1042/BJ20061461
URL : https://hal.archives-ouvertes.fr/hal-00478670

J. Merlin, L. Stechly, S. De-beauce, D. Monte, and E. Leteurtre, Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells, Oncogene, vol.9, issue.1, pp.2514-2525, 2011.
DOI : 10.1038/onc.2010.631

M. Van-der-sluis, M. Melis, N. Jonckheere, M. Ducourouble, and H. Buller, The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells, Biochemical and Biophysical Research Communications, vol.325, issue.3, pp.952-960, 2004.
DOI : 10.1016/j.bbrc.2004.10.108

C. Mariette, M. Perrais, E. Leteurtre, N. Jonckheere, and B. Hemon, Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway, Biochemical Journal, vol.377, issue.3, pp.701-708, 2004.
DOI : 10.1042/bj20031132

I. Van-seuningen, M. Perrais, P. Pigny, N. Porchet, and J. Aubert, Sequence of the 59-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells, Biochem J 348 Pt, vol.3, pp.675-686, 2000.

K. Carraway, M. Funes, H. Workman, and C. Sweeney, Contribution of Membrane Mucins to Tumor Progression Through Modulation of Cellular Growth Signaling Pathways, Curr Top Dev Biol, vol.78, pp.1-22, 2007.
DOI : 10.1016/S0070-2153(06)78001-2

M. Hollingsworth and B. Swanson, Mucins in cancer: protection and control of the cell surface, Nature Reviews Cancer, vol.4, issue.1, pp.45-60, 2004.
DOI : 10.1038/nrc1251

N. Jonckheere and I. Van-seuningen, The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers, Biochimie, vol.92, issue.1, pp.1-11, 2010.
DOI : 10.1016/j.biochi.2009.09.018

N. Moniaux, F. Escande, N. Porchet, J. Aubert, and S. Batra, Structural organization and classification of the human mucin genes, Frontiers in Bioscience, vol.6, issue.1, pp.1192-1206, 2001.
DOI : 10.2741/Moniaux

J. Rhodes, B. Campbell, and L. Yu, Lectin???epithelial interactions in the human colon, Biochemical Society Transactions, vol.36, issue.6, pp.1482-1486, 2008.
DOI : 10.1042/BST0361482

Q. Zhao, M. Barclay, J. Hilkens, X. Guo, and H. Barrow, Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis, Molecular Cancer, vol.9, issue.1, p.154, 2010.
DOI : 10.1186/1476-4598-9-154

S. Senapati, P. Chaturvedi, W. Chaney, S. Chakraborty, and V. Gnanapragassam, Novel Interaction of MUC4 and Galectin: Potential Pathobiological Implications for Metastasis in Lethal Pancreatic Cancer, Clinical Cancer Research, vol.17, issue.2, pp.267-274, 2011.
DOI : 10.1158/1078-0432.CCR-10-1937

S. Chang, A. Dohrman, C. Basbaum, S. Ho, and T. Tsuda, Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer, Gastroenterology, vol.107, issue.1, pp.28-36, 1994.
DOI : 10.1016/0016-5085(94)90057-4

M. Erkan, C. Reiser-erkan, C. Michalski, and J. Kleeff, Tumor microenvironment and progression of pancreatic cancer, Exp Oncol, vol.32, pp.128-131, 2010.

B. Farrow, D. Albo, and D. Berger, The Role of the Tumor Microenvironment in the Progression of Pancreatic Cancer, Journal of Surgical Research, vol.149, issue.2, pp.319-328, 2008.
DOI : 10.1016/j.jss.2007.12.757

D. Mahadevan, V. Hoff, and D. , Tumor-stroma interactions in pancreatic ductal adenocarcinoma, Molecular Cancer Therapeutics, vol.6, issue.4, pp.1186-1197, 2007.
DOI : 10.1158/1535-7163.MCT-06-0686

M. Junttila, S. Li, and J. Westermarck, Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival, The FASEB Journal, vol.22, issue.4, pp.954-965, 2008.
DOI : 10.1096/fj.06-7859rev

M. Perrais, P. Pigny, M. Ducourouble, D. Petitprez, and N. Porchet, Characterization of Human Mucin Gene MUC4 Promoter. IMPORTANCE OF GROWTH FACTORS AND PROINFLAMMATORY CYTOKINES FOR ITS REGULATION IN PANCREATIC CANCER CELLS, Journal of Biological Chemistry, vol.276, issue.33, pp.30923-30933, 2001.
DOI : 10.1074/jbc.M104204200

E. Shaulian and K. M. , AP-1 in cell proliferation and survival, Oncogene, vol.20, issue.19, pp.2390-2400, 2001.
DOI : 10.1038/sj.onc.1204383

E. Wagner and A. Nebreda, Signal integration by JNK and p38 MAPK pathways in cancer development, Nature Reviews Cancer, vol.136, issue.8, pp.537-549, 2009.
DOI : 10.1038/nrc2694

D. Cheon, Y. Wang, J. Deng, Z. Lu, and L. Xiao, CA125/MUC16 Is Dispensable for Mouse Development and Reproduction, PLoS ONE, vol.93, issue.10, p.4675, 2009.
DOI : 10.1371/journal.pone.0004675.s003

N. Porchet, M. Buisine, J. Desseyn, N. Moniaux, and S. Nollet, G??nes MUC : une superfamille de g??nes ? Vers une classification fonctionnelle des apomucines humaines, Journal de la Soci??t?? de Biologie, vol.193, issue.1, pp.85-99, 1999.
DOI : 10.1051/jbio/1999193010085

R. Derynck, R. Akhurst, and A. Balmain, TGF-beta signaling in tumor suppression and cancer progression, Nature Genetics, vol.29, issue.2, pp.117-129, 2001.
DOI : 10.1038/ng1001-117

M. Kielosto, P. Nummela, K. Jarvinen, M. Yin, and E. Holtta, Identification of integrins ??6 and ??7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells, International Journal of Cancer, vol.22, issue.5, pp.1065-1073, 2009.
DOI : 10.1002/ijc.24391

D. Artis, N. Humphreys, C. Potten, N. Wagner, and W. Muller, ??7 integrin-deficient mice: delayed leukocyte recruitment and attenuated protective immunity in the small intestine during enteric helminth infection, European Journal of Immunology, vol.30, issue.6, pp.1656-1664, 2000.
DOI : 10.1002/1521-4141(200006)30:6<1656::AID-IMMU1656>3.0.CO;2-Z

M. Tidswell, R. Pachynski, S. Wu, S. Qiu, and E. Dunham, Structurefunction analysis of the integrin beta 7 subunit: identification of domains involved in adhesion to MAdCAM-1, J Immunol, vol.159, pp.1497-1505, 1997.

J. Breuss, J. Gallo, H. Delisser, I. Klimanskaya, and H. Folkesson, Expression of the beta 6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling, J Cell Sci, vol.108, pp.2241-2251, 1995.

N. Walsh, M. Clynes, J. Crown, O. Donovan, and N. , Alterations in integrin expression modulates invasion of pancreatic cancer cells, Journal of Experimental & Clinical Cancer Research, vol.28, issue.1, p.140, 2009.
DOI : 10.1186/1756-9966-28-140

J. Fogh, T. Orfeo, J. Tiso, F. Sharkey, and J. Fogh, Twenty-Three New Human Tumor Lines Established in Nude Mice, Pathobiology, vol.48, issue.3, pp.229-239, 1980.
DOI : 10.1159/000162990

Y. Kim, H. Kern, T. Mullins, M. Koriwchak, and R. Metzgar, Characterization of Clones of a Human Pancreatic Adenocarcinoma Cell Line Representing Different Stages of Differentiation, Pancreas, vol.4, issue.3, pp.353-362, 1989.
DOI : 10.1097/00006676-198906000-00013