Identification of pluripotent and adult stem cell genes unrelated to cell cycle and associated with poor prognosis in multiple myeloma.

Abstract : Gene expression-based scores used to predict risk in cancer frequently include genes coding for DNA replication, repair or recombination. Using two independent cohorts of 206 and 345 previously-untreated patients with Multiple Myeloma (MM), we identified 50 cell cycle-unrelated genes overexpressed in multiple myeloma cells (MMCs) compared to normal human proliferating plasmablasts and non-proliferating bone marrow plasma cells and which have prognostic value for overall survival. Thirty-seven of these 50 myeloma genes (74%) were enriched in genes overexpressed in one of 3 normal human stem cell populations--pluripotent (18), hematopoietic (10) or mesenchymal stem cells (9)--and only three genes were enriched in one of 5 populations of differentiated cells (memory B lymphocytes, T lymphocytes, polymorphonuclear cells, monocytes, osteoclasts). These 37 genes shared by MMCs and adult or pluripotent stem cells were used to build a stem cell score ((SC)score), which proved to be strongly prognostic in the 2 independent cohorts of patients compared to other gene expression-based risk scores or usual clinical scores using multivariate Cox analysis. This finding highlights cell cycle-unrelated prognostic genes shared by myeloma cells and normal stem cells, whose products might be important for normal and malignant stem cell biology.
Type de document :
Article dans une revue
PLoS ONE, Public Library of Science, 2012, 7 (7), pp.e42161. 〈10.1371/journal.pone.0042161〉
Liste complète des métadonnées

Littérature citée [50 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00802686
Contributeur : Monique Frei <>
Soumis le : mercredi 20 mars 2013 - 11:55:30
Dernière modification le : vendredi 20 octobre 2017 - 01:17:33
Document(s) archivé(s) le : dimanche 2 avril 2017 - 15:51:05

Fichier

journalplusone.004216_2012.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Alboukadel Kassambara, Dirk Hose, Jérôme Moreaux, Thierry Rème, Jennifer Torrent, et al.. Identification of pluripotent and adult stem cell genes unrelated to cell cycle and associated with poor prognosis in multiple myeloma.. PLoS ONE, Public Library of Science, 2012, 7 (7), pp.e42161. 〈10.1371/journal.pone.0042161〉. 〈inserm-00802686〉

Partager

Métriques

Consultations de la notice

197

Téléchargements de fichiers

134