N. Giuliani and V. Rizzoli, Myeloma cells and bone marrow osteoblast interactions: role in the development of osteolytic

T. Andersen, K. Soe, T. Sondergaard, T. Plesner, and J. Delaisse, Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells, British Journal of Haematology, vol.19, issue.4
DOI : 10.1111/j.1365-2141.2009.07980.x

J. Moreaux, D. Hose, A. Kassambara, T. Reme, P. Moine et al., Cancer and the microenvironment: myeloma-osteoclast interactions as a

T. Matthes, I. Dunand-sauthier, M. Santiago-raber, K. Krause, O. Donze et al., Production of the plasma-cell survival factor a proliferationa functional component of a plasma cell niche in the bone marrow, Blood, vol.116, issue.11, pp.1867-1875, 2010.

K. Olive, M. Jacobetz, C. Davidson, A. Gopinathan, D. Mcintyre et al., Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer, Science, vol.324, issue.5933, 2009.
DOI : 10.1126/science.1171362

B. Shum, M. Huseni, D. Powers, A. Nanisetti, Y. Zhang et al., CS1, a potential new therapeutic antibody target for the treatment of multiple myeloma, Clin Cancer Res, 2008.

H. Olteanu, A. Harrington, P. Hari, and S. Kroft, CD200 expression in plasma cell myeloma 2011; is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2 and -3, Br J Haematol. Br J Cancer, vol.88, issue.6, pp.855-862, 2003.

J. Rossi, N. Fegueux, Z. Lu, E. Legouffe, C. Exbrayat et al., Optimizing the use of anti-interleukin-6 monoclonal antibody with dexamethasone and 140???mg/m2 of melphalan in multiple myeloma: results of a pilot study including biological aspects, Bone Marrow Transplantation, vol.36, issue.9, pp.771-779, 2005.
DOI : 10.1038/sj.bmt.1705138
URL : https://hal.archives-ouvertes.fr/inserm-00136072

A. Radbruch, G. Muehlinghaus, E. Luger, A. Inamine, K. Smith et al., Competence and competition: the challenge of becoming a long-lived plasma cell, Nature Reviews Immunology, vol.106, issue.10
DOI : 10.1038/nri1886

E. Mohr, K. Serre, R. Manz, A. Cunningham, M. Khan et al., Dendritic Cells and Monocyte/Macrophages That Create the IL-6 Age-associated changes in counts and detailed www.impactjournals.com/oncotarget characterization of circulating normal CD138-and CD138+ plasma cells, Andres M and Myeloma Stem Cell N. Circulating human B and plasma cells, pp.1016-1020, 2010.

A. Caraux, M. Perez-andres, M. Larroque, G. Requirand, Z. Lu et al., Mobilization of plasma cells in healthy individuals treated with granulocyte colony-stimulating factor for haematopoietic stem cell collection, Immunology, vol.273, issue.2, pp.266-272, 2011.
DOI : 10.1111/j.1365-2567.2010.03361.x

B. Paiva, M. Perez-andres, M. Vidriales, J. Almeida, N. De-las-heras et al., Competition between clonal plasma cells and normal cells for potentially overlapping bone marrow niches is associated with a progressively altered cellular distribution 39 A phase 2 study of bortezomib in relapsed, refractory myeloma, N Engl J