P. Kwan and M. Brodie, Early Identification of Refractory Epilepsy, New England Journal of Medicine, vol.342, issue.5, pp.314-319, 2000.
DOI : 10.1056/NEJM200002033420503

N. Temkin, Preventing and treating posttraumatic seizures: The human experience, Epilepsia, vol.58, issue.Suppl. 10, pp.10-13, 2009.
DOI : 10.1111/j.1528-1167.2008.02005.x

J. François, E. Koning, A. Ferrandon, and A. Nehlig, The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy, Epilepsy Research, vol.72, issue.2-3, pp.147-163, 2006.
DOI : 10.1016/j.eplepsyres.2006.07.014

C. Brandt, A. Gastens, M. Sun, M. Hausknecht, and W. Löscher, Treatment with valproate after status epilepticus: Effect on neuronal damage, epileptogenesis, and behavioral alterations in rats, Neuropharmacology, vol.51, issue.4, pp.789-804, 2006.
DOI : 10.1016/j.neuropharm.2006.05.021

C. Brandt, M. Glien, A. Gastens, M. Fedrowitz, K. Bethmann et al., Prophylactic treatment with levetiracetam after status epilepticus: Lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats, Neuropharmacology, vol.53, issue.2, pp.207-221, 2007.
DOI : 10.1016/j.neuropharm.2007.05.001

A. Pitkänen, J. Nissinen, E. Jolkkonen, J. Tuunanen, and T. Halonen, Effects of vigabatrin treatment on status epilepticus-induced neuronal damage and mossy fiber sprouting in the rat hippocampus, Epilepsy Research, vol.33, issue.1, pp.67-85, 1999.
DOI : 10.1016/S0920-1211(98)00074-6

A. Vezzani, A. Friedman, and R. Dingledine, The role of inflammation in epileptogenesis, Neuropharmacology, vol.69
DOI : 10.1016/j.neuropharm.2012.04.004

P. Buckmaster, . Jl, M. Avoli, M. Rogawski, and R. Olsen, Mossy Fiber Sprouting in the Dentate Gyrus.I nJasper's Basic Mechanisms of the Epilepsies [Internet], National Center for Biotechnology Information (US, vol.2012

A. Pitkänen, J. Nissinen, K. Lukasiuk, L. Jutila, L. Paljärvi et al., Association Between the Density of Mossy Fiber Sprouting and Seizure Frequency in Experimental and Human Temporal Lobe Epilepsy, Epilepsia, vol.15, issue.s6, pp.24-29, 2000.
DOI : 10.1016/S0006-8993(97)00087-5

E. Bahh, B. Lespinet, V. Lurton, D. Coussemacq, M. et al., Correlations Between Granule Cell Dispersion, Mossy Fiber Sprouting, and Hippocampal Cell Loss in Temporal Lobe Epilepsy, Epilepsia, vol.15, issue.10, pp.1393-1401, 1999.
DOI : 10.1006/exnr.1997.6469

R. Sankar, D. Shin, H. Liu, A. Mazarati, A. Pereira-de-vasconcelos et al., Patterns of status epilepticus-induced neuronal injury during development and long-term consequences, pp.8382-8393, 1998.

R. Sankar, D. Shin, A. Mazarati, H. Liu, H. Katsumori et al., Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity, Annals of Neurology, vol.98, issue.4, pp.580-589, 2000.
DOI : 10.1002/1531-8249(200010)48:4<580::AID-ANA4>3.0.CO;2-B

S. Auvin, D. Shin, A. Mazarati, J. Nakagawa, J. Miyamoto et al., Inflammation Exacerbates Seizure-induced Injury in the Immature Brain, Epilepsia, vol.190, issue.20, pp.27-34, 2007.
DOI : 10.1111/j.1341-8076.2005.00266.x

S. Auvin, A. Mazarati, D. Shin, and R. Sankar, Inflammation enhances epileptogenesis in the developing rat brain, Neurobiology of Disease, vol.40, issue.1, pp.303-310, 2010.
DOI : 10.1016/j.nbd.2010.06.004

J. Cavazos, G. Golarai, and T. Sutula, Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence, J Neurosci, vol.11, pp.2795-2803, 1991.

K. Jung, K. Chu, S. Lee, J. Kim, D. Sinn et al., Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus, Neurobiology of Disease, vol.23, issue.2, pp.237-246, 2006.
DOI : 10.1016/j.nbd.2006.02.016

H. Zhang, R. Sun, G. Lei, L. Yang, and C. Liu, Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats, Journal of Zhejiang University SCIENCE B, vol.9, issue.11, pp.903-915, 2008.
DOI : 10.1631/jzus.B0820018

N. Polascheck, M. Bankstahl, and W. Löscher, The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy, Experimental Neurology, vol.224, issue.1, pp.219-233, 2010.
DOI : 10.1016/j.expneurol.2010.03.014

L. Holtman, E. Van-vliet, R. Van-schaik, C. Queiroz, E. Aronica et al., Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy, Epilepsy Research, vol.84, issue.1, pp.56-66, 2009.
DOI : 10.1016/j.eplepsyres.2008.12.006

L. Holtman, E. Van-vliet, P. Edelbroek, E. Aronica, and J. Gorter, Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy, Epilepsy Research, vol.91, issue.1, pp.49-56, 2010.
DOI : 10.1016/j.eplepsyres.2010.06.011

J. Levin, G. Serrano, and R. Dingledine, Reduction in delayed mortality and subtle improvement in retrograde memory performance in pilocarpine-treated mice with conditional neuronal deletion of cyclooxygenase-2 gene, Epilepsia, vol.9, issue.8, pp.1411-1420, 2012.
DOI : 10.1111/j.1528-1167.2012.03584.x

T. Ravizza, F. Noé, D. Zardoni, V. Vaghi, M. Sifringer et al., Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1?? production, Neurobiology of Disease, vol.31, issue.3, pp.327-333, 2008.
DOI : 10.1016/j.nbd.2008.05.007

M. Maroso, S. Balosso, T. Ravizza, V. Iori, C. Wright et al., Interleukin-1?? Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice, Neurotherapeutics, vol.11, issue.suppl 5, pp.304-315, 2011.
DOI : 10.1007/s13311-011-0039-z

E. Gutierrez, W. Banks, and A. Kastin, Blood-borne interleukin-1 receptor antagonist crosses the blood-brain barrier, Journal of Neuroimmunology, vol.55, issue.2, pp.153-160, 1994.
DOI : 10.1016/0165-5728(94)90005-1

A. Greenhalgh, J. Galea, A. Dénes, P. Tyrrell, and N. Rothwell, Rapid brain penetration of interleukin-1 receptor antagonist in rat cerebral ischaemia: pharmacokinetics, distribution, protection, British Journal of Pharmacology, vol.35, issue.1, pp.153-159, 2010.
DOI : 10.1111/j.1476-5381.2010.00684.x

S. Zucchini, A. Buzzi, M. Barbieri, D. Rodi, B. Paradiso et al., FGF-2 Overexpression Increases Excitability and Seizure Susceptibility but Decreases Seizure-Induced Cell Loss, Journal of Neuroscience, vol.28, issue.49, pp.13112-13124, 2008.
DOI : 10.1523/JNEUROSCI.1472-08.2008

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3844742

B. Paradiso, P. Marconi, S. Zucchini, E. Berto, A. Binaschi et al., Localized delivery of fibroblast growth factor-2 and brain-derived neurotrophic factor reduces spontaneous seizures in an epilepsy model, Proceedings of the National Academy of Sciences, vol.106, issue.17, pp.7191-7196, 2009.
DOI : 10.1073/pnas.0810710106

R. Bovolenta, S. Zucchini, B. Paradiso, D. Rodi, F. Merigo et al., Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures, Journal of Neuroinflammation, vol.7, issue.1, pp.81-86, 2010.
DOI : 10.1186/1742-2094-7-81

URL : http://doi.org/10.1186/1742-2094-7-81