J. Scott, B. Chin, M. Bilban, and L. Otterbein, Restoring HOmeostasis: is heme oxygenase-1 ready for the clinic?, Trends in Pharmacological Sciences, vol.28, issue.5, pp.200-205, 2007.
DOI : 10.1016/j.tips.2007.03.006

S. Ryter, J. Alam, and A. Choi, Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications, Physiological Reviews, vol.86, issue.2, pp.583-650, 2006.
DOI : 10.1152/physrev.00011.2005

J. Clark, C. Green, and R. Motterlini, Involvement of the Heme Oxygenase???Carbon Monoxide Pathway in Keratinocyte Proliferation, Biochemical and Biophysical Research Communications, vol.241, issue.2, pp.215-220, 1997.
DOI : 10.1006/bbrc.1997.7742

K. Peyton, S. Reyna, G. Chapman, D. Ensenat, X. Liu et al., Heme oxygenase-1-derived carbon monoxide is an autocrine inhibitor of vascular smooth muscle cell growth, Blood, vol.99, issue.12, pp.4443-4448, 2002.
DOI : 10.1182/blood.V99.12.4443

R. Motterlini, C. Green, and R. Foresti, Regulation of Heme Oxygenase-1 by Redox Signals Involving Nitric Oxide, Antioxidants & Redox Signaling, vol.4, issue.4, pp.615-624, 2002.
DOI : 10.1089/15230860260220111

M. Vesely, D. Exon, J. Clark, R. Foresti, C. Green et al., Heme oxygenase-1 induction in skeletal muscle cells: hemin and sodium nitroprusside are regulators in vitro

K. Poss and S. Tonegawa, Heme oxygenase 1 is required for mammalian iron reutilization, Proceedings of the National Academy of Sciences, vol.94, issue.20, pp.10919-10924, 1997.
DOI : 10.1073/pnas.94.20.10919

K. Ohta, A. Yachie, K. Fujimoto, H. Kaneda, T. Wada et al., Tubular injury as a cardinal pathologic feature in human heme oxygenase-1 deficiency, American Journal of Kidney Diseases, vol.35, issue.5, pp.863-870, 2000.
DOI : 10.1016/S0272-6386(00)70256-3

B. Zuckerbraun, B. Chin, B. Wegiel, T. Billiar, E. Czsimadia et al., Carbon monoxide reverses established pulmonary hypertension, The Journal of Experimental Medicine, vol.267, issue.9, pp.2109-2119, 2006.
DOI : 10.1172/JCI23203

J. Kohmoto, A. Nakao, T. Kaizu, A. Tsung, A. Ikeda et al., Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts, Surgery, vol.140, issue.2, pp.179-185, 2006.
DOI : 10.1016/j.surg.2006.03.004

R. Motterlini and L. Otterbein, The therapeutic potential of carbon monoxide, Nature Reviews Drug Discovery, vol.51, issue.9, pp.728-743, 2010.
DOI : 10.1038/nrd3228

R. Motterlini, J. Clark, R. Foresti, P. Sarathchandra, B. Mann et al., Carbon Monoxide-Releasing Molecules: Characterization of Biochemical and Vascular Activities, Circulation Research, vol.90, issue.2
DOI : 10.1161/hh0202.104530

J. Clark, P. Naughton, S. Shurey, C. Green, T. Johnson et al., Cardioprotective Actions by a Water-Soluble Carbon Monoxide-Releasing Molecule, Circulation Research, vol.93, issue.2, pp.2-8, 2003.
DOI : 10.1161/01.RES.0000084381.86567.08

J. Varadi, I. Lekli, B. Juhasz, I. Bacskay, G. Szabo et al., Beneficial effects of carbon monoxide-releasing molecules on post-ischemic myocardial recovery, Life Sciences, vol.80, issue.17, pp.1619-1626, 2007.
DOI : 10.1016/j.lfs.2007.01.047

S. Lancel, S. Hassoun, R. Favory, B. Decoster, R. Motterlini et al., Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis, Journal of Pharmacology and Experimental Therapeutics, vol.329, issue.2, pp.641-648, 2009.
DOI : 10.1124/jpet.108.148049

D. Backer, O. Elinck, E. Blanckaert, B. Leybaert, L. Motterlini et al., Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress, Gut, vol.58, issue.3, pp.347-356, 2009.
DOI : 10.1136/gut.2008.155481

N. Maicas, M. Ferrandiz, I. Devesa, R. Motterlini, M. Koenders et al., The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model, European Journal of Pharmacology, vol.634, issue.1-3, pp.184-191, 2010.
DOI : 10.1016/j.ejphar.2010.02.028

A. Yabluchanskiy, P. Sawle, S. Homer-vanniasinkam, C. Green, R. Foresti et al., CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke*, Critical Care Medicine, vol.40, issue.2, pp.544-552, 2012.
DOI : 10.1097/CCM.0b013e31822f0d64

S. Chlopicki, R. Olszanecki, E. Marcinkiewicz, M. Lomnicka, and R. Motterlini, Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase, Cardiovascular Research, vol.71, issue.2, pp.393-401, 2006.
DOI : 10.1016/j.cardiores.2006.03.011

K. Kramkowski, A. Leszczynska, A. Mogielnicki, S. Chlopicki, A. Fedorowicz et al., Antithrombotic Properties of Water-Soluble Carbon Monoxide-Releasing Molecules, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.32, issue.9, pp.2149-2157, 2012.
DOI : 10.1161/ATVBAHA.112.253989

URL : https://hal.archives-ouvertes.fr/inserm-00732395

P. Urquhart, G. Rosignoli, D. Cooper, R. Motterlini, and M. Perretti, Carbon Monoxide-Releasing Molecules Modulate Leukocyte-Endothelial Interactions under Flow, Journal of Pharmacology and Experimental Therapeutics, vol.321, issue.2, pp.656-662, 2007.
DOI : 10.1124/jpet.106.117218

F. Zobi, A. Degonda, M. Schaub, and A. Bogdanova, Complexes, Inorganic Chemistry, vol.49, issue.16, pp.7313-7322, 2010.
DOI : 10.1021/ic100458j

C. Photoinduced, cellular uptake and cytotoxicity of a tris(pyrazolyl)methane (tpm) manganese tricarbonyl complex, Chem Commun, vol.15, pp.1798-1800, 2008.

R. Kretschmer, G. Gessner, H. Gorls, S. Heinemann, and M. Westerhausen, Dicarbonyl-bis(cysteamine)iron(II): A light induced carbon monoxide releasing molecule based on iron (CORM-S1), Journal of Inorganic Biochemistry, vol.105, issue.1, pp.6-9, 2011.
DOI : 10.1016/j.jinorgbio.2010.10.006

A. Atkin, S. Williams, P. Sawle, R. Motterlini, J. Lynam et al., mu(2)-Alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism, Dalton Trans, vol.19, pp.3653-3656, 2009.

S. Romanski, B. Kraus, U. Schatzschneider, J. Neudorfl, S. Amslinger et al., Acyloxybutadiene Iron Tricarbonyl Complexes as Enzyme-Triggered CO-Releasing Molecules (ET-CORMs), Angewandte Chemie International Edition, vol.180, issue.10, pp.2392-2396, 2011.
DOI : 10.1002/anie.201006598

R. Rimmer, H. Richter, and P. Ford, A Photochemical Precursor for Carbon Monoxide Release in Aerated Aqueous Media, Inorganic Chemistry, vol.49, issue.3, pp.1180-1185, 2010.
DOI : 10.1021/ic902147n

P. Sawle, J. Hammad, I. Fairlamb, B. Moulton, O. Brien et al., Bioactive Properties of Iron-Containing Carbon Monoxide-Releasing Molecules, Journal of Pharmacology and Experimental Therapeutics, vol.318, issue.1, pp.403-410, 2006.
DOI : 10.1124/jpet.106.101758

L. Hewison, S. Crook, T. Johnson, B. Mann, H. Adams et al., Iron indenyl carbonyl compounds: CO-releasing molecules, Dalton Transactions, vol.348, issue.38, pp.8967-8975, 2010.
DOI : 10.1039/c0dt00203h

S. Crook, B. Mann, J. Meijer, H. Adams, P. Sawle et al., [Mn(CO)4{S2CNMe(CH2CO2H)}], a new water-soluble CO-releasing molecule, Dalton Transactions, vol.318, issue.16, pp.4230-4235, 2011.
DOI : 10.1039/c1dt10125k

L. Hewison, T. Johnson, B. Mann, A. Meijer, P. Sawle et al., A re-investigation of [Fe(l-cysteinate)2(CO)2]2???: an example of non-heme CO coordination of possible relevance to CO binding to ion channel receptors, Dalton Transactions, vol.4, issue.33, pp.8328-8334, 2011.
DOI : 10.1039/c1dt10338e

A. Nesmeyanov and I. Kritsakaya, Some views on the structure and chemistry of iron ??-allyl complexes, Journal of Organometallic Chemistry, vol.14, issue.2, pp.387-394, 1968.
DOI : 10.1016/S0022-328X(00)87678-0

H. Murdoch and E. Weiss, ?-Allyl-eisencarbonyl-halogenide, Helvetica Chimica Acta, vol.1, issue.6, pp.1927-1933, 2004.
DOI : 10.1002/hlca.19620450625

J. Dieter and K. Nicholas, A convenient stereoselective synthesis of cationic (??3-allyl)iron tetracarbonyl complexes, Journal of Organometallic Chemistry, vol.212, issue.1, pp.107-113, 1981.
DOI : 10.1016/S0022-328X(00)85530-8

D. Enders, B. Jandeleit, V. Berg, S. Raabe, G. Runsink et al., Iron-Mediated Allylic Substitution Reactions with Chirality Transfer. Stereochemistry of the Formation of Diastereo- and Enantiomerically Enriched Olefinic and Allylic Tetracarbonyl Iron Complexes, Organometallics, vol.20, issue.21, pp.4312-4332, 2001.
DOI : 10.1021/om010343l

P. Sawle, R. Foresti, B. Mann, T. Johnson, C. Green et al., Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages, British Journal of Pharmacology, vol.103, issue.6, pp.800-810, 2005.
DOI : 10.1038/sj.bjp.0706241

R. Motterlini, B. Mann, T. Johnson, J. Clark, R. Foresti et al., Bioactivity and Pharmacological Actions of Carbon Monoxide-Releasing Molecules, Current Pharmaceutical Design, vol.9, issue.30, pp.2525-2539, 2003.
DOI : 10.2174/1381612033453785

A. Atkin, J. Lynam, B. Moulton, P. Sawle, R. Motterlini et al., Modification of the deoxy-myoglobin/carbonmonoxy-myoglobin UV-vis assay for reliable determination of CO-release rates from organometallic carbonyl complexes, Dalton Transactions, vol.227, issue.21, pp.5755-5761, 2011.
DOI : 10.1039/c0dt01809k

S. Mclean, B. Mann, and R. Poole, Sulfite species enhance carbon monoxide release from CO-releasing molecules: Implications for the deoxymyoglobin assay of activity, Analytical Biochemistry, vol.427, issue.1, pp.36-40, 2012.
DOI : 10.1016/j.ab.2012.04.026

R. Motterlini, P. Sawle, S. Bains, J. Hammad, A. R. Foresti et al., CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule, The FASEB Journal, vol.19, pp.284-286, 2005.
DOI : 10.1096/fj.04-2169fje

M. Desmard, K. Davidge, O. Bouvet, D. Morin, D. Roux et al., A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia, The FASEB Journal, vol.23, issue.4, pp.1023-1031, 2009.
DOI : 10.1096/fj.08-122804

J. Clark, R. Foresti, C. Green, and R. Motterlini, Dynamics of haem oxygenase-1 expression and bilirubin production in cellular protection against oxidative stress, Biochemical Journal, vol.348, issue.3, pp.615-619, 2000.
DOI : 10.1042/bj3480615

N. Garrido-mesa, D. Camuesco, B. Arribas, M. Comalada, E. Bailon et al., The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties, Pharmacological Research, vol.63, issue.4, pp.308-319, 2011.
DOI : 10.1016/j.phrs.2010.12.011

R. Foresti, H. J. Clark, J. Johnson, R. Mann, B. Friebe et al., Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule, British Journal of Pharmacology, vol.93, issue.3, pp.453-460, 2004.
DOI : 10.1038/sj.bjp.0705825

V. Khanna, M. Jain, M. Barthwal, D. Kalita, J. Boruah et al., Vasomodulatory effect of novel peroxovanadate compounds on rat aorta: Role of rho kinase and nitric oxide/cGMP pathway, Pharmacological Research, vol.64, issue.3, pp.274-282, 2011.
DOI : 10.1016/j.phrs.2011.03.016

R. Motterlini, Carbon monoxide-releasing molecules (CO-RMs): vasodilatory, anti-ischaemic and anti-inflammatory activities: Figure 1, Biochemical Society Transactions, vol.35, issue.5, pp.1142-1146, 2007.
DOI : 10.1042/BST0351142

R. Foresti and R. Motterlini, Interaction of Carbon Monoxide with Transition Metals: Evolutionary Insights into Drug Target Discovery, Current Drug Targets, vol.11, issue.12, pp.1595-1604, 2010.
DOI : 10.2174/1389450111009011595

A. Sandouka, B. Fuller, B. Mann, C. Green, R. Foresti et al., Treatment with CO-RMs during cold storage improves renal function at reperfusion, Kidney International, vol.69, issue.2, pp.239-247, 2006.
DOI : 10.1038/sj.ki.5000016

Y. Tayem, T. Johnson, B. Mann, C. Green, and R. Motterlini, Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule, AJP: Renal Physiology, vol.290, issue.4, pp.789-794, 2006.
DOI : 10.1152/ajprenal.00363.2005

M. Gonzalez, M. Yim, S. Cheng, A. Moyes, A. Hobbs et al., Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules, Inorganic Chemistry, vol.51, issue.1, pp.601-608, 2012.
DOI : 10.1021/ic2021287

D. Bikiel, S. Gonzalez, D. Salvo, F. Milagre, H. Eberlin et al., Tetrachlorocarbonyliridates: Water-Soluble Carbon Monoxide Releasing Molecules Rate-Modulated by the Sixth Ligand, Inorganic Chemistry, vol.50, issue.6, pp.2334-2345, 2011.
DOI : 10.1021/ic102038v

W. Zhang, A. Atkin, R. Thatcher, A. Whitwood, I. Fairlamb et al., Diversity and design of metal-based carbon monoxide-releasing molecules (CO-RMs) in aqueous systems: revealing the essential trends, Dalton Transactions, vol.12, issue.22, pp.4351-4358, 2009.
DOI : 10.1039/b819091g

K. Decaluwe, B. Pauwels, S. Verpoest, and J. Van-de-voorde, Divergent mechanisms involved in CO and CORM-2 induced vasorelaxation, European Journal of Pharmacology, vol.674, issue.2-3, pp.370-377, 2012.
DOI : 10.1016/j.ejphar.2011.11.004

M. Desmard, R. Foresti, D. Morin, M. Dagoussat, A. Berdeaux et al., by Carbon Monoxide-Releasing Molecules, Antioxidants & Redox Signaling, vol.16, issue.2, pp.153-163, 2011.
DOI : 10.1089/ars.2011.3959

URL : https://hal.archives-ouvertes.fr/inserm-00656413

S. Stohs and D. Bagchi, Oxidative mechanisms in the toxicity of metal ions, Free Radical Biology and Medicine, vol.18, issue.2, pp.321-336, 1995.
DOI : 10.1016/0891-5849(94)00159-H

A. Tavares, M. Teixeira, C. Romao, J. Seixas, L. Nobre et al., Reactive Oxygen Species Mediate Bactericidal Killing Elicited by Carbon Monoxide-releasing Molecules, Journal of Biological Chemistry, vol.286, issue.30, pp.26708-26717, 2011.
DOI : 10.1074/jbc.M111.255752

T. Murray, C. Okegbe, Y. Gao, B. Kazmierczak, R. Motterlini et al., The Carbon Monoxide Releasing Molecule CORM-2 Attenuates Pseudomonas aeruginosa Biofilm Formation, PLoS ONE, vol.41, issue.Pt 6, p.35499, 2012.
DOI : 10.1371/journal.pone.0035499.s004

C. Jackson, S. Schmitt, Q. Dou, and J. Kodanko, : Photoactivated Carbon Monoxide Release, Growth Inhibitory Activity, and Peptide Ligation, Inorganic Chemistry, vol.50, issue.12, pp.5336-5338, 2011.
DOI : 10.1021/ic200676s