Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.

Jean Bousquet 1, 2, * Josep Anto 3, 4, 5, 6 Pascal Demoly 7, 8 Holger Schünemann 9 Alkis Togias 10 Mübeccel Akdis 11 Charles Auffray 12 Claus Bachert 13 Thomas Bieber 14 Philippe Bousquet 1 Kai-Håkon Carlsen 15 Thomas Casale 16 Alavaro Cruz 17 Thomas Keil 18 Karin Lodrup Carlsen 15 Marcus Maurer 19 K. Ohta 20 N. G. Papadopoulos 21 M. Roman Rodriguez 22 B. Samolinski 23 I. Agache 24 A. Andrianarisoa 25 I. Annesi-Maesano 26 F. Ballester 27 C. E. Baena-Cagnani 28, 29 X. Basagaña 3, 4, 5 E. D. Bateman 30 E. H. Bel 31 A. Bedbrook 7 B. Beghé 32 M. Beji 33 Ali Ben Kheder 34 M. Benet 3, 4, 5 Kazi Saifuddin Bennoor 35 K. C. Bergmann 19 Fouad Berrissoul 36 Carsten Bindslev Jensen 37 Eugene Bleecker 38 S. Bonini 39 A. L. Boner 40 L. P. Boulet 41 Christopher Brightling 42 Jan Brozek 9 Andrew Bush 43 W. W. Busse 44 Paulo Augusto Moreira Camargos 45 Giorgio Walter Canonica 46 Warner Carr 47 Alfredo Cesario 48, 49 Y. Z. Chen 50 A. M. Chiriac 1 David Costa 51 Latonia Cox 52 Adnan Custovic 53 Ronald Dahl 54 Ulf Darsow 55 Toufik Didi 56 Habib Douagui 57 Ruta Dubakiene 58 Abdellah El-Meziane 59 Joao Fonseca 60 W. J. Fokkens 61 E. Fthenou 62 Amiran Gamkrelidze 63 J. Garcia-Aymerich 3, 4, 5, 6 Roy Gerth van Wijk 64 E. Gimeno-Santos 3 Stefano Guerra 3, 4, 5, 65 Tari Haahtela 66 H. Haddad 67 Peter Hellings 68 B. Hellquist-Dahl 54 C. Hohmann 18 Peter Howarth 69 J. O. Hourihane 70 Marc Humbert 71 Bénédicte Jacquemin 2 Jocelyne Just 72 Omer Kalayci 73 Michael Kaliner 74 Francine Kauffmann 2 Marjan Kerkhof 75 G. Khayat 76 Bernard Koffi N'Goran 77 M. Kogevinas 3, 4, 5 Gerard Koppelman 78 Marek Kowalski 79 Inger Kull 80, 81 Piotr Kuna 82 Désirée Larenas 83 I. Lavi 3 Lan Thi Tuyet Le 84 Phil Lieberman 85 Brian Lipworth 86 Bassam Mahboub 87 M. J. Makela 66 Francis Martin 88 Fernando Martinez 89 Gailen Marshall 90 A. Mazon 27 Erik Melen 91 Eli Meltzer 92 F. Mihaltan 93 Yousser Mohammad 94 Azzeddine Mohammadi 95 Isabelle Momas 96 Mario Morais-Almeida 97 Joaquim Mullol 98 Antonella Muraro 99 Robert Naclerio 100 Salim Nafti 101 Leyla Namazova-Baranova 102 Martijn Nawijn 103 Tshipukane Nyembue 104 Sam Oddie 105 Robyn O'Hehir 106 Yoshitaka Okamoto 107 M. P. Orru 108 Cevdet Ozdemir 109 G. S. Ouedraogo 110 Susanna Palkonen 111 Petr Panzner 112 G. Passalacqua 46 Ruby Pawankar 113 Bernard Pigearias 114 Isabelle Pin 115 M. Pinart 3 Christophe Pison 116 Ted Popov 117 Daniela Porta 118 Dirkje Postma 78 David Price 119 Klaus Rabe 120 Julia Ratomaharo 121 S. Reitamo 65 Djamel Rezagui 122 Johannes Ring 123 R. Roberts 124 Joseph Roca 125 B. Rogala 126 Antonino Romano 127 José Rosado-Pinto 128 Dermot Ryan 129, 130 Mario Sanchez-Borges 131 Glenis Scadding 132 Aziz Sheikh 133 Frances Estelle Reed Simons 134 Valérie Siroux 115 Peter Schmid-Grendelmeier 135 H. A. Smit 136 Talant Sooronbaev 137 Renato Stein 3, 138 P. J. Sterk 31, 121 J. Sunyer 3, 4, 5, 6 Ingrid Terreehorst 139 Elina Toskala 140 Yves Tremblay 141 Rudolf Valenta 142 Dominique Valeyre 143 Olivier Vandenplas 144 Chris Van Weel 145 M. Vassilaki 62 R. Varraso 71, 2 Giovanni Viegi 146, 147 De Yun Wang 148 Magnus Wickman 149 Dennis Williams 150 Stefan Wöhrl 151 J. Wright 105 Arzu Yorgancioglu 152 Osman Yusuf 153 H. J. Zar 154 M. E. Zernotti 28 Mihaela Zidarn 155 N. Zhong 156 Torsten Zuberbier 19, 157
* Auteur correspondant
Abstract : Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
Type de document :
Article dans une revue
International Archives of Allergy and Immunology, Karger, 2012, 158 (3), pp.216-31. 〈10.1159/000332924〉
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Jean Bousquet, Josep Anto, Pascal Demoly, Holger Schünemann, Alkis Togias, et al.. Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper.. International Archives of Allergy and Immunology, Karger, 2012, 158 (3), pp.216-31. 〈10.1159/000332924〉. 〈inserm-00788048〉

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