Assessment of diastolic function from velocity-encoded cardiac magnetic resonance data in patients with hypertrophic cardiomyopathy

1532-429X-15-S1-P1701532-429X Poster presentation Assessment of diastolic function from velocity-encoded cardiac magnetic resonance data in patients with hypertrophic cardiomyopathy AshrafpoorGolmehr KachenouraNadjia BollacheEmilie MacronLaurent AzarineArshid BruguièreEric FontaineSébastien DesnosMichel HagègeAAlbert MousseauxElie RedheuilAlban

Hôpital Européen Georges Pompidou, Paris, France

Inserm U678, Université Pierre et Marie Curie Paris 6, Paris, France

Journal of Cardiovascular Magnetic Resonance Abstracts of the 16th Annual SCMR Scientific SessionsPublication of this supplement is fully supported by the Society for Cardiovascular Magnetic Resonance.Meeting abstracts16th Annual SCMR Scientific SessionsSan Francisco, CA, USA

31 January - 3 February 2013

http://www.scmr.org/1532-429X 2013 15 Suppl 1 P170 http://www.jcmr-online.com/content/15/S1/P170 10.1186/1532-429X-15-S1-P170 3012013 2013Ashrafpoor et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Background

Diastolic dysfunction evaluation may be relevant for early diagnosis of hypertrophic cardiomyopathy (HCM) and subsequent risk assessment. The aim of our study was to assess phase contrast cardiac magnetic resonance (PC-CMR) diastolic parameters obtained with a semi-automated method in relation to left ventricular (LV) remodeling and late gadolinium enhancement (LGE) in patients with HCM.

Methods

We studied 48 patients with HCM and 23 healthy volunteers matched for age, sex and body surface area (BSA). Mitral inflow and myocardial velocities were assessed using through plane 2D PC-CMR (VENC=150cm/s and 20cm/s respectively). Transmitral peak flow-rates (Ef and Af) and early E' peak myocardial longitudinal velocity were obtained semi-automatically using CardFlow (INSERM U678). LV volumes, segmental thickness and mass were obtained from SSFP images. LGE volume was quantified semi-automatically using a 6 SD threshold.

Results

Peak myocardial longitudinal velocity E' was significantly lower and E/E' was significantly higher in patients with HCM compared with controls (Table). We found a linear relationship between decreased E' and increased LV mass index (p<0.0001), decreased mass/end-diastolic volume (M/EDV) ratio (p<0.0001), increased LGE mass (p=0.04) and LGE extension (p=0.04). The relationships between E' and LV mass index and M/EDV were independent of age, gender, BSA and systolic blood pressure (p<0.001).

Table 1

Controls (n=23)

HCM (n=48)

LV mass (g)

132 (33)

195 (69)

0.0001

LV mass index (g/m2)

69 (13)

106 (36)

<0.0001

EDV (ml)

139 (37)

151 (45)

ESV (ml)

50 (14)

51 (23)

Mass/EDV (g/ml)

0.99 (0.3)

1.35 (0.5)

0.0026

LV ejection fraction (%)

64 (5)

66 (10)

Maximal wall thickness (mm)

20 (4)

Extent of LV hypertrophy (%)

16 (17)

LGE (g)

4.1 (4.6)

LGE (%)

2 .3 (2.2)

Ef/Af

1.21 (0.7)

1.47 (2.3)

E' (cm/s)

8.6 (4.7)

3.4 (1.6)

<0.0001

E/E'

8.1 (4.3)

25.3 (18.6)

0.0001

DT (ms)

213.9 (72.1)

241.4 (67.4)

0.11

LV, left ventricular; EDV, end-diastolic volume; ESV, end-systolic volume; LGE, late gadolinium enhancement; DT, deceleration time

Conclusions

Comparison of patients with HCM and healthy volunteers by CMR showed significantly altered LV diastolic function related to LV hypertrophy and LGE. Assessment of diastolic function may be considered for a comprehensive cardiac evaluation in HCM.

Funding

None