Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Fluids and Barriers of the CNS Année : 2012

Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.

Anny-Claude Luissint
  • Fonction : Auteur
  • PersonId : 935155
Cédric Artus
  • Fonction : Auteur
  • PersonId : 935156
Fabienne Glacial
  • Fonction : Auteur
  • PersonId : 935157
Kayathiri Ganeshamoorthy
  • Fonction : Auteur
  • PersonId : 935158
Pierre-Olivier Couraud
  • Fonction : Auteur correspondant
  • PersonId : 922210

Connectez-vous pour contacter l'auteur

Résumé

ABSTRACT: The Blood--brain barrier (BBB), present at the level of the endothelium of cerebral blood vessels, selectively restricts the blood-to-brain paracellular diffusion of compounds; it is mandatory for cerebral homeostasis and proper neuronal function. The barrier properties of these specialized endothelial cells notably depend on tight junctions (TJs) between adjacent cells: TJs are dynamic structures consisting of a number of transmembrane and membrane-associated cytoplasmic proteins, which are assembled in a multimolecular complex and acting as a platform for intracellular signaling. Although the structural composition of these complexes has been well described in the recent years, our knowledge about their functional regulation still remains fragmentary. Importantly, pericytes, embedded in the vascular basement membrane, and perivascular microglial cells, astrocytes and neurons contribute to the regulation of endothelial TJs and BBB function, altogether constituting the so-called neurovascular unit.The present review summarizes our current understanding of the structure and functional regulation of endothelial TJs at the BBB. Accumulating evidence points to a correlation between BBB dysfunction, alteration of TJ complexes and progression of a variety of CNS diseases, such as stroke, multiple sclerosis and brain tumors, as well as neurodegenerative diseases like Parkinson's and Alzheimer's diseases. Understanding how TJ integrity is controlled may thus help improve drug delivery across the BBB and the design of therapeutic strategies for neurological disorders.
Fichier principal
Vignette du fichier
2045-8118-9-23.pdf (410.34 Ko) Télécharger le fichier
2045-8118-9-23.xml (172.56 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Loading...

Dates et versions

inserm-00772323 , version 1 (10-01-2013)

Identifiants

Citer

Anny-Claude Luissint, Cédric Artus, Fabienne Glacial, Kayathiri Ganeshamoorthy, Pierre-Olivier Couraud. Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation.. Fluids and Barriers of the CNS, 2012, 9 (1), pp.23. ⟨10.1186/2045-8118-9-23⟩. ⟨inserm-00772323⟩
114 Consultations
264 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More