Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Arthritis Research and Therapy Année : 2012

Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation.

Yoland Schoindre
  • Fonction : Auteur
  • PersonId : 934581
Noël Zahr
  • Fonction : Auteur
  • PersonId : 934584
Kubéraka Mariampillai
  • Fonction : Auteur
  • PersonId : 934585
Lucile Musset
  • Fonction : Auteur
  • PersonId : 934587
Jean-Charles Piette
  • Fonction : Auteur
  • PersonId : 934588

Résumé

ABSTRACT: INTRODUCTION: Systemic lupus erythematosus (SLE) is a T and B cell-dependent autoimmune disease characterized by the appearance of autoantibodies, a global regulatory T cells (Tregs) depletion and an increase in Th17 cells. Recent studies have shown the multifaceted immunomodulatory effects of vitamin D, notably the expansion of Tregs and the decrease of Th1 and Th17 cells. A significant correlation between higher disease activity and lower serum 25-hydroxyvitamin D levels [25(OH)D] was also shown. METHODS: In this prospective study, we evaluated the safety and the immunological effects of vitamin D supplementation (100 000 IU of cholecalciferol per week for 4 weeks, followed by 100 000 IU of cholecalciferol per month for 6 months.) in 20 SLE patients with hypovitaminosis D. RESULTS: Serum 25(OH)D levels dramatically increased under vitamin D supplementation from 18.7±6.7 at day 0 to 51.4±14.1 (p<0.001) at 2 months and 41.5±10.1 ng/mL (p<0.001) at 6 months. Vitamin D was well tolerated and induced a preferential increase of naïve CD4+ T cells, an increase of regulatory T cells and a decrease of effector Th1 and Th17 cells. Vitamin D also induced a decrease of memory B cells and anti-DNA antibodies. No modification of the prednisone dosage or initiation of new immunosuppressant agents was needed in all patients. We did not observe SLE flare during the 6 months follow-up period. CONCLUSIONS: This preliminary study suggests the beneficial role of vitamin D in SLE patients and needs to be confirmed in randomized controlled trials.
Fichier principal
Vignette du fichier
ar4060.pdf (2.18 Mo) Télécharger le fichier
AR4060-S1.DOC (380.5 Ko) Télécharger le fichier
ar4060.xml (67.56 Ko) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Format : Autre
Format : Autre
Loading...

Dates et versions

inserm-00768700 , version 1 (23-12-2012)

Identifiants

Citer

Benjamin Terrier, Nicolas Derian, Yoland Schoindre, Wahiba Chaara, Guillaume Geri, et al.. Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation.. Arthritis Research and Therapy, 2012, 14 (5), pp.R221. ⟨10.1186/ar4060⟩. ⟨inserm-00768700⟩
252 Consultations
281 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More