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Predictive value of daily living score in acute respiratory failure of COPD patients requiring invasive mechanical ventilation pilot study.
Langlet K., Van Der Linden T., Launois C., Fourdin C., Cabaret P., Kerkeni N., Barbe C., Lebargy F., Deslée G.
BMC Pulmonary Medicine 12, 1 (2012) 66 - http://www.hal.inserm.fr/inserm-00762253
 (23078114) 
Predictive value of daily living score in acute respiratory failure of COPD patients requiring invasive mechanical ventilation pilot study.
Ketty Langlet () 1, 2, Thierry Van Der Linden1, Claire Launois3, Caroline Fourdin1, Philippe Cabaret1, Nadia Kerkeni1, Coralie Barbe2, François Lebargy2, Gaetan Deslée3
1 :  Service d'Urgences et de Réanimation médicale polyvalente
Hôpital Saint Philibert
Rue du Grand But BP 249 59462 Lomme Cedex
France
2 :  Unité d'Aide Méthodologique
Hôpital Robert Debré – CHU Reims
Pôle Recherche et Innovations - Rue du Général Kœnig 51100 Reims
France
3 :  Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques
INSERM : U903
CHU Hôpital Maison Blanche Reims
France
ABSTRACT: BACKGROUND: Mechanical ventilation (MV) is imperative in many forms of acute respiratory failure (ARF) in COPD patients. Previous studies have shown the difficulty to identify parameters predicting the outcome of COPD patients treated by invasive MV. Our hypothesis was that a non specialized score as the activities daily living (ADL) score may help to predict the outcome of these patients. METHODS: We studied the outcome of 25 COPD patients admitted to the intensive care unit for ARF requiring invasive MV. The patients were divided into those weaning success (group A n = 17, 68%) or failure (group B n = 8, 32%). We investigated the correlation between the ADL score and the outcome and mortality. RESULTS: The ADL score was higher in group A (5.1 +/-1.1 vs 3.7 +/- 0.7 in group B, p < 0.01). Weaning was achieved in 76.5of the cases with an ADL score [greater than or equal to] 4 and in 23.5of the cases with an ADL score < 4 (p < 0.05). Pulmonary function test, arterial blood gases collected during period of clinical stability and at admission and nutritional status were similar in both groups. The mortality, at six months, was 36%. The ADL score was a significant predictor of 6-month mortality (80with an ADL score <4, 20with an ADL score [greater than or equal to]4, p < 0.01). CONCLUSION: Our pilot study demonstrates that the ADL score is predictive of weaning success and mortality at 6 months, suggesting that the assessment of daily activities should be an important component of ARF management in COPD patients.
Sciences du Vivant/Médecine humaine et pathologie/Pneumologie et système respiratoire
Anglais
1471-2466

Articles dans des revues avec comité de lecture
10.1186/1471-2466-12-66
BMC Pulmonary Medicine
Publisher BioMed Central
ISSN 1471-2466 
internationale
18/10/2012
18/10/2012
12
1
66

Chronic obstructive pulmonary disease – Acute respiratory failure – Mechanical ventilation weaning – Mortality – Activities of Daily Living score
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