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The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity: a pilot study.
Launois C., Barbe C., Bertin E., Nardi J., Perotin J.-M., Dury S., Lebargy F., Deslee G.
BMC Pulmonary Medicine 12, 1 (2012) 61 - http://www.hal.inserm.fr/inserm-00761665
 (23025326) 
The modified Medical Research Council scale for the assessment of dyspnea in daily living in obesity: a pilot study.
Claire Launois () 1, Coralie Barbe2, Eric Bertin3, Julie Nardi1, Jeanne-Marie Perotin1, Sandra Dury1, François Lebargy1, Gaëtan Deslee1
1 :  Plasticité de l'épithélium respiratoire dans les conditions normales et pathologiques
INSERM : U903
CHU Hôpital Maison Blanche Reims
France
2 :  Unité d'Aide Méthodologique
Hôpital Robert Debré – CHU Reims
Pôle Recherche et Innovations - Rue du Général Kœnig 51100 Reims
France
3 :  Service d'Endocrinologie-Diabétologie-Nutrition
Hôpital Robert Debré – CHU Reims
Rue du Général Kœnig 51100 Reims
France
ABSTRACT: BACKGROUND: Dyspnea is very frequent in obese subjects. However, its assessment is complex in clinical practice. The modified Medical Research Council scale (mMRC scale) is largely used in the assessment of dyspnea in chronic respiratory diseases, but has not been validated in obesity. The objectives of this study were to evaluate the use of the mMRC scale in the assessment of dyspnea in obese subjects and to analyze its relationships with the 6-minute walk test (6MWT), lung function and biological parameters. METHODS: Forty-five obese subjects (17 M/28 F, BMI: 43 +/- 9 kg/m2) were included in this pilot study. Dyspnea in daily living was evaluated by the mMRC scale and exertional dyspnea was evaluated by the Borg scale after 6MWT. Pulmonary function tests included spirometry, plethysmography, diffusing capacity of carbon monoxide and arterial blood gases. Fasting blood glucose, total cholesterol, triglyceride, N-terminal pro brain natriuretic peptide, C-reactive protein and hemoglobin levels were analyzed. RESULTS: Eighty-four percent of patients had a mMRC >= 1 and 40% a mMRC >= 2. Compared to subjects with no dyspnea (mMRC = 0), a mMRC >= 1 was associated with a higher BMI (44 +/- 9 vs 36 +/- 5 kg/m2, p = 0.01), and a lower expiratory reserve volume (ERV) (50 +/- 31 vs 91 +/- 32%, p = 0.004), forced expiratory volume in one second (FEV1) (86 +/- 17 vs 101 +/- 16%, p = 0.04) and distance covered in 6MWT (401 +/- 107 vs 524 +/- 72 m, p = 0.007). A mMRC >= 2 was associated with a higher Borg score after the 6MWT (4.7 +/- 2.5 vs 6.5 +/- 1.5, p < 0.05). CONCLUSION: This study confirms that dyspnea is very frequent in obese subjects. The differences between the "dyspneic" and the "non dyspneic" groups assessed by the mMRC scale for BMI, ERV, FEV1 and distance covered in 6MWT suggests that the mMRC scale might be an useful and easy-to-use tool to assess dyspnea in daily living in obese subjects.
Sciences du Vivant/Médecine humaine et pathologie/Pneumologie et système respiratoire
Anglais
1471-2466

Articles dans des revues avec comité de lecture
10.1186/1471-2466-12-61
BMC Pulmonary Medicine
Publisher BioMed Central
ISSN 1471-2466 
internationale
01/10/2012
01/10/2012
12
1
61

Dyspnea – Obesity – Modified Medical Research Council scale – Six-minute walk test – Lung function
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