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Critical role of surface chemical modifications induced by length shortening on multi-walled carbon nanotubes-induced toxicity.
Bussy C., Pinault M., Cambedouzou J., Landry M. Julie, Jegou P., Mayne-L'hermite M., Launois P., Boczkowski J., Lanone S.
Particle and Fibre Toxicology 9, 1 (2012) 46 - http://www.hal.inserm.fr/inserm-00761589
 (23181604) 
Critical role of surface chemical modifications induced by length shortening on multi-walled carbon nanotubes-induced toxicity.
Cyrill Bussy1, 2, Mathieu Pinault3, Julien Cambedouzou2, Marion Landry1, Pascale Jegou4, Martine Mayne-L'hermite3, Pascale Launois2, Jorge Boczkowski1, 5, 6, Sophie Lanone () 1, 5
1 :  Institut Mondor de Recherche Biomédicale
INSERM : U955 – Université Paris-Est Créteil Val-de-Marne (UPEC) – IFR10
8 rue du Général Sarrail, 94010 Créteil
France
2 :  LPS - Laboratoire de Physique des Solides
http://www.lps.u-psud.fr/
CNRS : UMR8502 – Université Paris XI - Paris Sud
Bat. 510 91405 Orsay cedex
France
3 :  LFP - URA 2453 - Laboratoire Francis PERRIN
http://www-lfp.cea.fr
CNRS : URA2453 – CEA : DSM/IRAMIS
LFP, CEA/SACLAY, 91191 GIF SUR YVETTE CEDEX
France
4 :  SPCSI - Service de Physique et de Chimie des Surfaces et Interfaces
http://www-drecam.cea.fr/spcsi/
CEA : DSM/IRAMIS
DSM/DRECAM/SPCSI, CEA Saclay F-91191 Gif sur Yvette
France
5 :  Service de Pneumologie et Pathologie Professionnelle
CHI Créteil – Faculté de Médecine
40 avenue de Verdun - 94010 Créteil cedex
France
6 :  Service de physiologie, explorations fonctionnelles [Mondor]
Assistance publique - Hôpitaux de Paris (AP-HP) – Hôpital Henri Mondor – Université Paris-Est Créteil Val-de-Marne (UPEC)
51, av du Maréchal de Tassigny, Créteil
France
ABSTRACT: Given the increasing use of carbon nanotubes (CNT) in composite materials and their possible expansion to new areas such as nanomedicine which will both lead to higher human exposure, a better understanding of their potential to cause adverse effects on human health is needed. Like other nanomaterials, the biological reactivity and toxicity of CNT were shown to depend on various physicochemical characteristics, and length has been suggested to play a critical role.We therefore designed a comprehensive study that aimed at comparing the effects on murine macrophages of two samples of multi-walled CNT (MWCNT) specifically synthesized following a similar production process (aerosol-assisted CVD), and used a soft ultrasonic treatment in water to modify the length of one of them.We showed that modification of the length of MWCNT leads, unavoidably, to accompanying structural (i.e. defects) and chemical (i.e. oxidation) modifications that affect both surface and residual catalyst iron nanoparticle content of CNT. The biological response of murine macrophages to the two different MWCNT samples was evaluated in terms of cell viability, pro-inflammatory cytokines secretion and oxidative stress. We showed that structural defects and oxidation both induced by the length reduction process are at least as responsible as the length reduction itself for the enhanced pro-inflammatory and pro-oxidative response observed with short (oxidized) compared to long (pristine) MWCNT.In conclusion, our results stress that surface properties should be considered, alongside the length, as essential parameters in CNT-induced inflammation, especially when dealing with a safe design of CNT, for application in nanomedicine for example.
Sciences du Vivant/Santé publique et épidémiologie
Anglais
1743-8977

Articles dans des revues avec comité de lecture
10.1186/1743-8977-9-46
Particle and Fibre Toxicology
Publisher BioMed Central
ISSN 1743-8977 
internationale
27/11/2012
27/11/2012
9
1
46

Carbon nanotubes – Macrophages – Length – Surface chemistry
This work was supported by the Région Ile-de-France in the framework of C'nano IdF (NANOTUBTOX project), as well as for the MEG FEG instrument used, C'Nano-IdF is the nanoscience competence center of Paris Region, supported by CNRS, CEA, MESR and Région Ile-de-France.
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