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Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study.
Troude P., Ancelet S., Guibert J., Pouly J.-L., Bouyer J., de La Rochebrochard E.
BMC Pregnancy and Childbirth 12, 1 (2012) 77 - http://www.hal.inserm.fr/inserm-00760462
 (22862824) 
Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study.
Pénélope Troude () 1, 2, Sophie Ancelet1, 3, Juliette Guibert4, 5, Jean-Luc Pouly6, Jean Bouyer1, 2, Elise de La Rochebrochard1, 2
1 :  CESP - Centre de recherche en épidémiologie et santé des populations
INSERM : U1018 – Hôpital Paul Brousse – Assistance publique - Hôpitaux de Paris (AP-HP) – Université Paris XI - Paris Sud – Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)
16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
France
2 :  INED - Institut National d'Etudes Démographiques Paris
INED
France
3 :  IRSN - Institut de radioprotection et de sûreté nucléaire
http://www.irsn.org/
Ministère de l'écologie de l'Energie, du Développement durable et de l'Aménagement du territoire – Ministère de l'économie, de l'industrie et de l'emploi – Ministère de l'Enseignement Supérieur et de la Recherche Scientifique – Ministère de la Défense – Ministère de la santé
BP17 92262 Fontenay-aux-Roses Cedex
France
4 :  Unité de Médecine de la Reproduction
Hôpital Cochin – Assistance publique - Hôpitaux de Paris (AP-HP)
Service de Gynécologie-Obstétrique II - 27 rue du Faubourg Saint-Jacques 75014 Paris
France
5 :  Laboratoire de Procréation Médicalement Assistée
Institut Mutualiste de Montsouris
42 Boulevard Jourdan 75014 Paris
France
6 :  FIV - Fécondation In Vitro sans micro-injection
CHU Clermont-Ferrand
Reproduction AMP CECOS - Assistance Médicale à la Procréation (AMP) - 58 rue Montalembert 63003 Clermont-Ferrand
France
ABSTRACT: BACKGROUND: As discontinuation in in vitro fertilization (IVF) programs has been associated with a poor prognosis, one hypothesis is that some couple-specific predictive factors in IVF may be shared with opposite effect by both successful (i.e. live birth) and treatment discontinuation processes. Our objective was to perform a joint analysis of these two processes to examine the hypothesis of a link between the two processes. METHODS: Analyses were conducted on a retrospective cohort of 3,002 women who began IVF between 1998 and 2002 in two French IVF centers: a Parisian center and a center in a medium-sized city in central France. A shared random effects model based on a joint modelization of IVF treatment success and discontinuation was used to study the link between the two processes. RESULTS: Success and discontinuation processes were significantly linked in the medium-sized city center, whereas they were not linked in the Parisian center. The center influenced risk of treatment discontinuation but not chance of success. The well-known inverse-J relation between the woman's age and chance of success was observed, as expected. Risk of discontinuation globally increased as the woman's age increased. CONCLUSIONS: The link between success and discontinuation processes could depend on the fertility center. In particular, the woman's decision to pursue or to discontinue IVF in a particular center could depend on the presence of other IVF centers in the surrounding area.
Sciences du Vivant/Médecine humaine et pathologie/Gynécologie et obstétrique
Anglais
1471-2393

Articles dans des revues avec comité de lecture
10.1186/1471-2393-12-77
BMC Pregnancy and Childbirth
Publisher BioMed Central
ISSN 1471-2393 
internationale
03/08/2012
03/08/2012
12
1
77

This project was supported by the Agence Nationale de la Recherche [n°ANR-06-BLAN-0221-01] and by a post-doctoral grant from the Région Ile-de-France and Paris-Sud XI University [n°F-08-1220/R].
15951
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