PMID: identifiant
de la référence Pubmed : |
 |
 (22862824)  |
|
| titre : |
|
Joint modeling of success and treatment discontinuation in in vitro fertilization programs: a retrospective cohort study. |
|
| auteur(s) : |
|
Pénélope Troude ( ) 1, 2, Sophie Ancelet1, 3, Juliette Guibert4, 5, Jean-Luc Pouly6, Jean Bouyer1, 2, Elise de La Rochebrochard1, 2 |
|
| laboratoire : |
|
|
|
| résumé : |
|
ABSTRACT: BACKGROUND: As discontinuation in in vitro fertilization (IVF) programs has been associated with a poor prognosis, one hypothesis is that some couple-specific predictive factors in IVF may be shared with opposite effect by both successful (i.e. live birth) and treatment discontinuation processes. Our objective was to perform a joint analysis of these two processes to examine the hypothesis of a link between the two processes. METHODS: Analyses were conducted on a retrospective cohort of 3,002 women who began IVF between 1998 and 2002 in two French IVF centers: a Parisian center and a center in a medium-sized city in central France. A shared random effects model based on a joint modelization of IVF treatment success and discontinuation was used to study the link between the two processes. RESULTS: Success and discontinuation processes were significantly linked in the medium-sized city center, whereas they were not linked in the Parisian center. The center influenced risk of treatment discontinuation but not chance of success. The well-known inverse-J relation between the woman's age and chance of success was observed, as expected. Risk of discontinuation globally increased as the woman's age increased. CONCLUSIONS: The link between success and discontinuation processes could depend on the fertility center. In particular, the woman's decision to pursue or to discontinue IVF in a particular center could depend on the presence of other IVF centers in the surrounding area. |
|
| domaine : |
|
Sciences du Vivant/Médecine humaine et pathologie/Gynécologie et obstétrique
|
|
langue du texte
intégral : |
|
Anglais |
|
| ISSN : |
|
1471-2393 |
|
|
| type de publication : |
|
Articles dans des revues avec comité de lecture |
|
| DOI : |
|
10.1186/1471-2393-12-77 |
|
| journal : |
|
|
|
| Audience : |
|
internationale |
|
| date de publication : |
|
03/08/2012 |
|
date de publication
électronique : |
|
03/08/2012 |
|
| volume : |
|
12 |
|
| numéro : |
|
1 |
|
| page, identifiant, ... : |
|
77 |
|
|
| contrat, financement : |
|
This project was supported by the Agence Nationale de la Recherche [n°ANR-06-BLAN-0221-01] and by a post-doctoral grant from the Région Ile-de-France and Paris-Sud XI University [n°F-08-1220/R]. |
|
| Projet ANR : |
|
| Référence du projet |
ANR-06-BLAN-0221-01 |
|
|
