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HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.
Guillaume S., Perroud N., Jollant F., Jaussent I., Olié E., Malafosse A., Courtet P.
Journal of Psychiatric Research (2012) epub ahead of print - http://www.hal.inserm.fr/inserm-00759957
HPA axis genes may modulate the effect of childhood adversities on decision-making in suicide attempters.
Sebastien Guillaume () 1, 2, Nader Perroud3, Fabrice Jollant4, Isabelle Jaussent1, 2, Emilie Olié1, 2, Alain Malafosse4, 5, Philippe Courtet1, 2
1 :  Urgence et post-urgence psychiatrique
Hôpital Lapeyronie – CHRU Montpellier
371, avenue du Doyen Gaston Giraud 34295 Montpellier cedex 5
2 :  Neuropsychiatrie : recherche épidémiologique et clinique
INSERM : U1061 – Université Montpellier I
Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier
3 :  Département de Psychiatrie
Hôpital Belle-Idée – Geneva University Hospitals
2 ch. du Petit-Bel-Air, 1225 Chêne-Bourg
4 :  McGill Group for Suicide Studies
Douglas Mental Health University Institute – McGill University
Montreal, Québec
5 :  Department of Medical Genetics and Laboratory
Geneva University Hospitals
2 ch Petit Bel-Air, CH-1225 Chêne-Bourg
decision-making and stress
Decision-making impairment is found in several neuropsychiatric disorders, including suicidal behavior, and has been shown to be modulated by genes. On the other hand, early trauma have/has been associated with poor mental health outcome in adulthood, in interaction with genetic factors, possibly through sustained alterations in the hypothalamic-pituitary-adrenal axis (HPA axis). Here, we aimed to investigate the effect of childhood trauma and its interaction with HPA-axis related genes on decision-making abilities in adulthood among a sample of suicide attempters. The Iowa Gambling Task (IGT) was used to assess decision-making in 218 patients with a history of suicide attempt. Participant fulfilled the Childhood Trauma Questionnaire to report traumatic childhood experiences. Patients were genotyped for single-nucleotide polymorphisms within CRHR1 and CRHR2 genes. Patients with a history of sexual abuse had significantly lower IGT scores than non-sexually abused individuals. Polymorphisms within CRHR1 and CRHR2 genes interacted with both childhood sexual abuse and emotional neglect to influence IGT performance. In conclusion, childhood sexual abuse and emotional neglect may have long-term effects on decision-making through an interaction with key HPA axis genes. Even if these results need to be replicated in other sample, impaired decision-making may thus be the dimension through which child maltreatment, in interaction with HPA axis related genes, may have a sustained negative impact on adult mental health.
Sciences du Vivant/Médecine humaine et pathologie/Psychiatrie et santé mentale

Articles dans des revues avec comité de lecture
Journal of Psychiatric Research (J Psychiatr Res)
Publisher Elsevier
ISSN 0022-3956 
epub ahead of print

Child abuse – Gene Environment Interaction – Stress – Decision-making – Attempted suicide.
This study received financial support from CHU Montpellier (PHRC UF 7653), Agence Nationale de la Recherche (ANR NEURO 2007 "GENESIS) and by the Swiss National Fund (Grants 320030-112084).
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