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Nanopsychiatry-The potential role of nanotechnologies in the future of psychiatry: A systematic review.
Fond G., Macgregor A., Miot S.
European Neuropsychopharmacology (2012) epub ahead of print - http://www.hal.inserm.fr/inserm-00759948
(23183130)
Nanopsychiatry-The potential role of nanotechnologies in the future of psychiatry: A systematic review.
Guillaume Fond () 1, 2, Alexandra Macgregor1, 2, Stéphanie Miot3
1 :  Neuropsychiatrie : recherche épidémiologique et clinique
INSERM : U1061 – Université Montpellier I
Hôpital La Colombière 39 AV Charles Flahault BP 34493 -Pav 42 Calixte Cavalier 34093 CEDEX 5 Montpellier
France
2 :  Service Universitaire de Psychiatrie Adulte
Hôpital La Colombière – CHRU Montpellier
39, avenue Charles Flahault 34295 Montpellier cedex 5
France
3 :  Physiopathologie des Maladies du Système Nerveux Central
INSERM : U952 – Université Pierre et Marie Curie (UPMC) - Paris VI – CNRS : UMR7224
Bât. B, 4ème étage, case courrier 37 9 quai Saint Bernard 75252 Paris Cedex 05
France
Nanomedicine is defined as the area using nanotechnology's concepts for the benefit of human beings' health and well being. In this article, we aimed to provide an overview of areas where nanotechnology is applied and how they could be extended to care for psychiatric illnesses. The main applications of nanotechnology in psychiatry are (i) pharmacology. There are two main difficulties in neuropharmacology: drugs have to pass the blood-brain barrier and then to be internalized by targeted cells. Nanoparticles could increase drugs bioavailability and pharmacokinetics, especially improving safety and efficacy of psychotropic drugs. Liposomes, nanosomes, nanoparticle polymers, nanobubbles are some examples of this targeted drug delivery. Nanotechnologies could also add new pharmacological properties, like nanoshells and dendrimers (ii) living analysis. Nanotechnology provides technical assistance to in vivo imaging or metabolome analysis (iii) central nervous system modeling. Research teams have succeeded to modelize inorganic synapses and mimick synaptic behavior, a step essential for further creation of artificial neural systems. Some nanoparticle assemblies present the same small worlds and free-scale networks architecture as cortical neural networks. Nanotechnologies and quantum physics could be used to create models of artificial intelligence and mental illnesses. We are not about to see a concrete application of nanomedicine in daily psychiatric practice. Even if nanotechnologies are promising, their safety is still inconsistent and this must be kept in mind. However, it seems essential that psychiatrists do not forsake this area of research the perspectives of which could be decisive in the field of mental illness.
Sciences du Vivant/Médecine humaine et pathologie/Psychiatrie et santé mentale
Anglais
1873-7862

Articles dans des revues avec comité de lecture
10.1016/j.euroneuro.2012.10.016
European Neuropsychopharmacology (Eur Neuropsychopharmacol)
Publisher Elsevier
ISSN 0924-977X 
internationale
22/11/2012
22/11/2012
epub ahead of print

nanopsychiatrie – psychiatrie – nanotechnologie – nanomédecine – nanocarrier – nanohub – imagerie – système nerveux central – liposome
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