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Helminth-infected patients with malaria: a low profile transmission hub?
Nacher M.
Malaria Journal 11, 1 (2012) 376 - http://www.hal.inserm.fr/inserm-00758017
 (23153258) 
Helminth-infected patients with malaria: a low profile transmission hub?
Mathieu Nacher () 1, 2
1 :  Epidémiologie des Parasitoses et Mycoses Tropicales
Université des Antilles et de la Guyane : EA3593
Campus Saint Denis, Cayenne, 97300
Guyane Française
2 :  Centre d'investigation clinique Antilles-Guyane
INSERM : CIE802 – CH Cayenne
Guyane Française
ABSTRACT: Eclipsed by the debates about malaria incidence and severity in individual patients, malaria transmission in helminth-infected persons has so far received very little attention. Studies in humans have shown increased malaria incidence and prevalence, and a trend for a reduction of symptoms in patients with malaria. This suggests that such patients could possibly be less likely to seek treatment thus carrying malaria parasites and their gametocytes for longer durations, therefore, being a greater potential source of transmission. In addition, in humans, a study showed increased gametocyte carriage, and in an animal model of helminth-malaria co-infection, there was increased malaria transmission. These elements converge towards the hypothesis that patients co-infected with worms and malaria may represent a hub of malaria transmission. The test of this hypothesis requires verifying, in different epidemiological settings, that helminth-infected patients have more gametocytes, that they have less symptomatic malaria and longer-lasting infections, and that they are more attractive for the vectors. The negative outcome in one setting of one of the above aspects does not necessarily mean that the other two aspects may suffice to increase transmission. If it is verified that patients co-infected by worms and malaria could be a transmission hub, this would be an interesting piece of strategic information in the context of the spread of anti-malarial resistance and the malaria eradication attempts.
Sciences du Vivant/Médecine humaine et pathologie/Maladies infectieuses
Anglais
1475-2875

Articles dans des revues avec comité de lecture
10.1186/1475-2875-11-376
Malaria Journal (Malar J)
Publisher BioMed Central
ISSN 1475-2875 
internationale
15/11/2012
15/11/2012
11
1
376

Malaria – Worms – Coinfection – Immunomodulation – Anemia – Asymptomatic – Transmission – Vector
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