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Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors.
Tong X., Garofalakis A., Dubois A., Boisgard R., Ducongé F., Trébossen R., Tavitian B.
EJNMMI Research 2, 1 (2012) 19 - http://www.hal.inserm.fr/inserm-00757432
 (22564761) 
Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors.
Xiao Tong1, Anikitos Garofalakis1, Albertine Dubois1, Raphaël Boisgard1, Frédéric Ducongé1, Régine Trébossen1, Bertrand Tavitian () 1
1 :  U1023 - Imagerie In Vivo de l'expression des gènes
http://www-dsv.cea.fr/dsv/instituts/institut-d-imagerie-biomedicale-i2bm
INSERM : U1023 – CEA : DSV/I2BM – Université Paris XI - Paris Sud
CEA - Service Hospitalier Frédéric Joliot 4, place du Général Leclerc 91401 Orsay Cedex
France
ABSTRACT: BACKGROUND: Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of the present study is to co-register fDOT and PET molecular images of tumors in mice automatically. METHODS: The coordinates of bimodal fiducial markers (FM) in regions of detection were automatically detected in planar optical images (x, y positions) in laser pattern optical surface images (z position) and in 3-D PET images. A transformation matrix was calculated from the coordinates of the FM in fDOT and in PET and applied in order to co-register images of mice bearing neuroendocrine tumors. RESULTS: The method yielded accurate non-supervised co-registration of fDOT and PET images. The mean fiducial registration error was smaller than the respective voxel sizes for both modalities, allowing comparison of the distribution of contrast agents from both modalities in mice. Combined imaging depicting tumor metabolism with PET-[18 F]2-deoxy-2-fluoro-D-glucose and blood pool with fDOT demonstrated partial overlap of the two signals. CONCLUSIONS: This automatic method for co-registration of fDOT with PET and other modalities is efficient, simple and rapid, opening up multiplexing capacities for experimental in vivo molecular imaging.
Sciences du Vivant/Ingénierie biomédicale/Imagerie
Sciences du Vivant/Ingénierie biomédicale
Anglais
2191-219X

Articles dans des revues avec comité de lecture
10.1186/2191-219X-2-19
EJNMMI Research (EJNMMI Res)
Publisher BioMed Central
ISSN 2191-219X 
internationale
07/05/2012
07/05/2012
2
1
19

Co-registration – fDOT – PET – Fiducial marker detection – Optical surface image – Neuroendocrine tumors – MEN2A
15769
Acronyme European Union Program FMT-XCT (grant agreement no. 201792)
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