Migraine -Current understanding and treatment, N Engl J Med, vol.346, pp.257-270, 2002. ,
Palotie, on behalf of the International Headache Genetics Consortium, Genome-wide association study of migraine implicates a common susceptibility variant on 8q22, Nat Genet, vol.1, issue.42, pp.869-873, 2010. ,
Genome-wide association study reveals three susceptibility loci for common migraine in the general population, Nat Genet, vol.43, pp.695-698, 2011. ,
Migraine as a Cerebral Ionopathy with Impaired Central Sensory Processing, Molecular Neurology, pp.439-461, 2007. ,
DOI : 10.1016/B978-012369509-3.50030-5
Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS, Nature Reviews Neurology, vol.460, issue.2, pp.86-96, 2012. ,
DOI : 10.1038/nrneurol.2011.228
The Clinical Spectrum of Familial Hemiplegic Migraine Associated with Mutations in a Neuronal Calcium Channel, New England Journal of Medicine, vol.345, issue.1, pp.17-24, 2001. ,
DOI : 10.1056/NEJM200107053450103
Molecular genetics of migraine, Human Genetics, vol.38, issue.Suppl 4, pp.115-132, 2009. ,
DOI : 10.1007/s00439-009-0684-z
Calcium Channelopathies, NeuroMolecular Medicine, vol.8, issue.3, pp.307-318, 2006. ,
DOI : 10.1385/NMM:8:3:307
Familial hemiplegic migraine, Neurotherapeutics, vol.20, issue.suppl 1, pp.274-284, 2007. ,
DOI : 10.1016/j.nurt.2007.01.008
Ca V 2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis, J Physiol Paris, 2012. ,
2.1 calcium channel function from mouse models of familial hemiplegic migraine, The Journal of Physiology, vol.97, issue.Suppl 1, pp.1871-1878, 2010. ,
DOI : 10.1113/jphysiol.2010.188003
Functional consequences of mutations in the human ? 1A calcium channel subunit linked to familial hemiplegic migraine, J Neurosci, vol.19, pp.1610-1619, 1999. ,
Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons, 1A2 2 [13], pp.13284-13289, 2002. ,
DOI : 10.1073/pnas.192242399
Gating Deficiency in a Familial Hemiplegic Migraine Type 1 Mutant P/Q-type Calcium Channel, Journal of Biological Chemistry, vol.280, issue.25, pp.24064-24071, 2005. ,
DOI : 10.1074/jbc.M502223200
A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression, Neuron, vol.41, pp.701-710, 2004. ,
High cortical spreading depression susceptibility and migraine-associated symptoms in Ca V 2.1 S218L mice, Ann Neurol, vol.67, pp.85-98, 2010. ,
Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice, Neuron, vol.61, issue.5, pp.762-673, 2009. ,
DOI : 10.1016/j.neuron.2009.01.027
2.1) calcium channels expressed in human embryonic kidney cells, The Journal of Physiology, vol.77, issue.2, pp.337-347, 2003. ,
DOI : 10.1113/jphysiol.2002.026716
The S218L familial hemiplegic migraine mutation promotes deinhibition of Cav2.1 calcium channels during direct G-protein regulation, Pfl??gers Archiv - European Journal of Physiology, vol.454, issue.Pt 1, pp.315-326, 2008. ,
DOI : 10.1007/s00424-008-0541-2
URL : https://hal.archives-ouvertes.fr/inserm-00376518
The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition, Pflügers Arch, vol.458, pp.489-502, 2009. ,
Structural elements in domain IV that influence biophysical and pharmacological properties of human ? 1A -containing high-voltageactivated calcium channels, Biophys J, pp.76-1384, 1999. ,
Cloning and expression of a neuronal calcium channel ? subunit, J Biol Chem, vol.268, pp.12359-12366, 1993. ,
Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit., Proceedings of the National Academy of Sciences, vol.89, issue.8, pp.3251-3255, 1992. ,
DOI : 10.1073/pnas.89.8.3251
Rim1 modulates direct G-protein regulation of Ca V 2.2 channels, Pflugers Arch, pp.461-447, 2011. ,
URL : https://hal.archives-ouvertes.fr/inserm-00587552
Dissection of functional domains of the voltage-dependent Ca 2+ channel ? 2 5 subunit, J Neurosci, vol.17, pp.6884-6891, 1997. ,
Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release, Journal of Biological Chemistry, vol.286, issue.18, pp.15757-15765, 2011. ,
DOI : 10.1074/jbc.M110.187757
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfl??gers Archiv - European Journal of Physiology, vol.12, issue.2, pp.391-85, 1981. ,
DOI : 10.1007/BF00656997
Channel Activity in HEK-293 Cells, Cellular and Molecular Neurobiology, vol.24, issue.3, pp.317-330, 2004. ,
DOI : 10.1023/B:CEMN.0000022765.52109.26
Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement, Proceedings of the National Academy of Sciences, vol.107, issue.25, pp.11352-11357, 2010. ,
DOI : 10.1073/pnas.1000142107
Computation of molecular electrostatics with boundary element methods, Biophysical Journal, vol.73, issue.4, pp.1830-1841, 1997. ,
DOI : 10.1016/S0006-3495(97)78213-4
Opioids: cellular mechanisms of tolerance and physical dependence, Current Opinion in Pharmacology, vol.5, issue.1, pp.60-68, 2005. ,
DOI : 10.1016/j.coph.2004.08.012
Comparison of N-and P/Q-type voltage-gated calcium channel current inhibition, J Neurosci, vol.17, pp.4570-4579, 1997. ,
calcium channels by different G protein ?? subunit isoforms, The Journal of Physiology, vol.17, issue.2, pp.203-212, 2000. ,
DOI : 10.1111/j.1469-7793.2000.00203.x
oocytes, The Journal of Physiology, vol.95, issue.3, pp.419-432, 2000. ,
DOI : 10.1111/j.1469-7793.2000.t01-1-00419.x
Protein-dependent facilitation of neuronal ?1A, ?1B, and ?1E Ca channels, J Neurosci, vol.18, pp.5240-5252, 1998. ,
Membrane binding of the colicin E1 channel: activity requires an electrostatic interaction of intermediate magnitude, Biophysical Journal, vol.70, issue.6, pp.2774-2783, 1996. ,
DOI : 10.1016/S0006-3495(96)79847-8
Molecular modelling investigation of wild-type and the R528H mutated segment IIS4 of human L-type voltage-gated calcium channels, Protein Engineering Design and Selection, vol.11, issue.11 ,
DOI : 10.1093/protein/11.11.1033
Electrostatic potentials of proteins in water: a structured continuum approach, Bioinformatics, vol.23, issue.2, pp.99-103, 2007. ,
DOI : 10.1093/bioinformatics/btl312
Presynaptic Ca2+ channels ??? integration centers for neuronal signaling pathways, Trends in Neurosciences, vol.29, issue.11, pp.617-624, 2006. ,
DOI : 10.1016/j.tins.2006.08.006
Primary structure and functional expression from complementary DNA of a brain calcium channel, Nature, vol.350, issue.6317, pp.398-402, 1991. ,
DOI : 10.1038/350398a0
Primary structure of a calcium channel that is highly expressed in the rat cerebellum., Proceedings of the National Academy of Sciences, vol.88, issue.13, pp.5621-5625, 1991. ,
DOI : 10.1073/pnas.88.13.5621
Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca 2+ channel gene CACNL1A4, Cell, vol.87, pp.543-552, 1996. ,
Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the ?1A-voltage- dependent calcium channel, Nat Genet, vol.15, pp.62-69, 1997. ,
Direct binding of G-protein ???? complex to voltage-dependent calcium channels, Nature, vol.385, issue.6615, pp.446-450, 1997. ,
DOI : 10.1038/385446a0
Crosstalk between G proteins and protein kinase C mediated by the calcium channel ??1 subunit, Nature, vol.385, issue.6615, pp.442-446, 1997. ,
DOI : 10.1038/385442a0
2 calcium channels, Channels, vol.20, issue.6, pp.497-509, 2010. ,
DOI : 10.1038/nature01772
Direct G Protein Modulation of Cav2 Calcium Channels, Pharmacological Reviews, vol.58, issue.4, pp.837-862, 2006. ,
DOI : 10.1124/pr.58.4.11
Migraine: gene mutations and functional consequences, Current Opinion in Neurology, vol.20, issue.3, pp.299-305, 2007. ,
DOI : 10.1097/WCO.0b013e3281338d1f