P. J. Goadsby, R. B. Lipton, and M. D. Ferrari, Migraine -Current understanding and treatment, N Engl J Med, vol.346, pp.257-270, 2002.

E. T. Kubisch, R. R. Dermitzakis, and A. Frants, Palotie, on behalf of the International Headache Genetics Consortium, Genome-wide association study of migraine implicates a common susceptibility variant on 8q22, Nat Genet, vol.1, issue.42, pp.869-873, 2010.

J. E. Griffiths, M. Buring, T. Kallela, C. Freilinger, P. M. Kubisch et al., Genome-wide association study reveals three susceptibility loci for common migraine in the general population, Nat Genet, vol.43, pp.695-698, 2011.

M. D. Ferrari, A. M. Van-den-maagdenberg, R. R. Frants, and P. J. Goadsby, Migraine as a Cerebral Ionopathy with Impaired Central Sensory Processing, Molecular Neurology, pp.439-461, 2007.
DOI : 10.1016/B978-012369509-3.50030-5

S. Rajakulendran, D. Kaski, and M. G. Hanna, Neuronal P/Q-type calcium channel dysfunction in inherited disorders of the CNS, Nature Reviews Neurology, vol.460, issue.2, pp.86-96, 2012.
DOI : 10.1038/nrneurol.2011.228

A. Ducros, C. Dernier, A. Joutel, M. Cecillon, C. Lescoat et al., The Clinical Spectrum of Familial Hemiplegic Migraine Associated with Mutations in a Neuronal Calcium Channel, New England Journal of Medicine, vol.345, issue.1, pp.17-24, 2001.
DOI : 10.1056/NEJM200107053450103

B. D. Vries, R. R. Frants, M. D. Ferrari, and A. M. , Molecular genetics of migraine, Human Genetics, vol.38, issue.Suppl 4, pp.115-132, 2009.
DOI : 10.1007/s00439-009-0684-z

R. Felix and C. Channelopathies, Calcium Channelopathies, NeuroMolecular Medicine, vol.8, issue.3, pp.307-318, 2006.
DOI : 10.1385/NMM:8:3:307

D. Pietrobon, Familial hemiplegic migraine, Neurotherapeutics, vol.20, issue.suppl 1, pp.274-284, 2007.
DOI : 10.1016/j.nurt.2007.01.008

O. D. Uchitel, C. G. Inchauspe, F. J. Urbano, and M. N. Di-guilmi, Ca V 2.1 voltage activated calcium channels and synaptic transmission in familial hemiplegic migraine pathogenesis, J Physiol Paris, 2012.

D. Pietrobon, 2.1 calcium channel function from mouse models of familial hemiplegic migraine, The Journal of Physiology, vol.97, issue.Suppl 1, pp.1871-1878, 2010.
DOI : 10.1113/jphysiol.2010.188003

M. Hans, S. Luvisetto, M. E. Williams, M. Spagnolo, A. Urrutia et al., Functional consequences of mutations in the human ? 1A calcium channel subunit linked to familial hemiplegic migraine, J Neurosci, vol.19, pp.1610-1619, 1999.

A. Tottene, T. Fellin, S. Pagnutti, S. Luvisetto, J. Striessnig et al., Familial hemiplegic migraine mutations increase Ca2+ influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons, 1A2 2 [13], pp.13284-13289, 2002.
DOI : 10.1073/pnas.192242399

C. F. Barrett, Y. Q. Cao, and R. W. Tsien, Gating Deficiency in a Familial Hemiplegic Migraine Type 1 Mutant P/Q-type Calcium Channel, Journal of Biological Chemistry, vol.280, issue.25, pp.24064-24071, 2005.
DOI : 10.1074/jbc.M502223200

. Ferrari, A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression, Neuron, vol.41, pp.701-710, 2004.

M. D. Pietrobon and . Ferrari, High cortical spreading depression susceptibility and migraine-associated symptoms in Ca V 2.1 S218L mice, Ann Neurol, vol.67, pp.85-98, 2010.

A. Tottene, R. Conti, A. Fabbro, D. Vecchia, M. Shapovalova et al., Enhanced Excitatory Transmission at Cortical Synapses as the Basis for Facilitated Spreading Depression in CaV2.1 Knockin Migraine Mice, Neuron, vol.61, issue.5, pp.762-673, 2009.
DOI : 10.1016/j.neuron.2009.01.027

K. Melliti, M. Grabner, and G. Seabrook, 2.1) calcium channels expressed in human embryonic kidney cells, The Journal of Physiology, vol.77, issue.2, pp.337-347, 2003.
DOI : 10.1113/jphysiol.2002.026716

N. Weiss, A. Sandoval, R. Felix, A. Van-den-maagdenberg, and M. D. Waard, The S218L familial hemiplegic migraine mutation promotes deinhibition of Cav2.1 calcium channels during direct G-protein regulation, Pfl??gers Archiv - European Journal of Physiology, vol.454, issue.Pt 1, pp.315-326, 2008.
DOI : 10.1007/s00424-008-0541-2
URL : https://hal.archives-ouvertes.fr/inserm-00376518

. Fernandez-fernandez, The hemiplegic migraine-associated Y1245C mutation in CACNA1A results in a gain of channel function due to its effect on the voltage sensor and G-protein-mediated inhibition, Pflügers Arch, vol.458, pp.489-502, 2009.

M. Hans, A. Urrutia, C. Deal, P. F. Brust, K. Stauderman et al., Structural elements in domain IV that influence biophysical and pharmacological properties of human ? 1A -containing high-voltageactivated calcium channels, Biophys J, pp.76-1384, 1999.

A. Castellano, X. Wei, L. Birnbaumer, and E. Perez-reyes, Cloning and expression of a neuronal calcium channel ? subunit, J Biol Chem, vol.268, pp.12359-12366, 1993.

H. L. Kim, H. Kim, P. Lee, R. G. King, and H. Chin, Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha 2 subunit., Proceedings of the National Academy of Sciences, vol.89, issue.8, pp.3251-3255, 1992.
DOI : 10.1073/pnas.89.8.3251

N. Weiss, A. Sandoval, S. Kyonaka, R. Felix, Y. Mori et al., Rim1 modulates direct G-protein regulation of Ca V 2.2 channels, Pflugers Arch, pp.461-447, 2011.
URL : https://hal.archives-ouvertes.fr/inserm-00587552

R. Felix, C. A. Gurnett, M. De-waard, and K. P. Campbell, Dissection of functional domains of the voltage-dependent Ca 2+ channel ? 2 5 subunit, J Neurosci, vol.17, pp.6884-6891, 1997.

M. A. Gandini, A. Sandoval, R. González-ramírez, Y. Mori, M. De-waard et al., Functional Coupling of Rab3-interacting Molecule 1 (RIM1) and L-type Ca2+ Channels in Insulin Release, Journal of Biological Chemistry, vol.286, issue.18, pp.15757-15765, 2011.
DOI : 10.1074/jbc.M110.187757

O. P. Hamill, A. Marty, E. Neher, B. Sakmann, and F. Sigworth, Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches, Pfl??gers Archiv - European Journal of Physiology, vol.12, issue.2, pp.391-85, 1981.
DOI : 10.1007/BF00656997

G. Avila, A. Sandoval, and R. Felix, Channel Activity in HEK-293 Cells, Cellular and Molecular Neurobiology, vol.24, issue.3, pp.317-330, 2004.
DOI : 10.1023/B:CEMN.0000022765.52109.26

X. Chen, Q. Wang, F. Ni, and J. Ma, Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement, Proceedings of the National Academy of Sciences, vol.107, issue.25, pp.11352-11357, 2010.
DOI : 10.1073/pnas.1000142107

J. Liang and S. Subramaniam, Computation of molecular electrostatics with boundary element methods, Biophysical Journal, vol.73, issue.4, pp.1830-1841, 1997.
DOI : 10.1016/S0006-3495(97)78213-4

C. P. Bailey and M. Connor, Opioids: cellular mechanisms of tolerance and physical dependence, Current Opinion in Pharmacology, vol.5, issue.1, pp.60-68, 2005.
DOI : 10.1016/j.coph.2004.08.012

K. P. Currie and A. P. Fox, Comparison of N-and P/Q-type voltage-gated calcium channel current inhibition, J Neurosci, vol.17, pp.4570-4579, 1997.

M. I. Arnot, S. C. Stotz, S. E. Jarvis, and G. W. Zamponi, calcium channels by different G protein ?? subunit isoforms, The Journal of Physiology, vol.17, issue.2, pp.203-212, 2000.
DOI : 10.1111/j.1469-7793.2000.00203.x

C. Cantí, Y. Bogdanov, and A. C. , oocytes, The Journal of Physiology, vol.95, issue.3, pp.419-432, 2000.
DOI : 10.1111/j.1469-7793.2000.t01-1-00419.x

U. Meza and B. Adams, Protein-dependent facilitation of neuronal ?1A, ?1B, and ?1E Ca channels, J Neurosci, vol.18, pp.5240-5252, 1998.

S. D. Zakharov, J. B. Heymann, Y. L. Zhang, and W. A. Cramer, Membrane binding of the colicin E1 channel: activity requires an electrostatic interaction of intermediate magnitude, Biophysical Journal, vol.70, issue.6, pp.2774-2783, 1996.
DOI : 10.1016/S0006-3495(96)79847-8

K. J. Schleifer and H. D. Höltje, Molecular modelling investigation of wild-type and the R528H mutated segment IIS4 of human L-type voltage-gated calcium channels, Protein Engineering Design and Selection, vol.11, issue.11
DOI : 10.1093/protein/11.11.1033

A. Hildebrandt, R. Blossey, S. Rjasanow, O. Kohlbacher, and H. P. Lenhof, Electrostatic potentials of proteins in water: a structured continuum approach, Bioinformatics, vol.23, issue.2, pp.99-103, 2007.
DOI : 10.1093/bioinformatics/btl312

R. M. Evans and G. W. Zamponi, Presynaptic Ca2+ channels ??? integration centers for neuronal signaling pathways, Trends in Neurosciences, vol.29, issue.11, pp.617-624, 2006.
DOI : 10.1016/j.tins.2006.08.006

Y. Mori, T. Friedrich, M. S. Kim, A. Mikami, J. Nakai et al., Primary structure and functional expression from complementary DNA of a brain calcium channel, Nature, vol.350, issue.6317, pp.398-402, 1991.
DOI : 10.1038/350398a0

T. V. Starr, W. Prystay, and T. P. Snutch, Primary structure of a calcium channel that is highly expressed in the rat cerebellum., Proceedings of the National Academy of Sciences, vol.88, issue.13, pp.5621-5625, 1991.
DOI : 10.1073/pnas.88.13.5621

G. J. Lindhout, M. H. Van-ommen, M. D. Hofker, R. Ferrari, and . Frants, Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the Ca 2+ channel gene CACNL1A4, Cell, vol.87, pp.543-552, 1996.

S. H. Dobyns, H. Y. Subramony, C. C. Zoghbi, and . Lee, Autosomal dominant cerebellar ataxia (SCA6) associated with small polyglutamine expansions in the ?1A-voltage- dependent calcium channel, Nat Genet, vol.15, pp.62-69, 1997.

M. De-waard, H. Liu, D. Walker, V. E. Scott, C. A. Gurnett et al., Direct binding of G-protein ???? complex to voltage-dependent calcium channels, Nature, vol.385, issue.6615, pp.446-450, 1997.
DOI : 10.1038/385446a0

G. W. Zamponi, E. Bourinet, D. Nelson, J. Nargeot, and T. P. Snutch, Crosstalk between G proteins and protein kinase C mediated by the calcium channel ??1 subunit, Nature, vol.385, issue.6615, pp.442-446, 1997.
DOI : 10.1038/385442a0

K. P. Currie, 2 calcium channels, Channels, vol.20, issue.6, pp.497-509, 2010.
DOI : 10.1038/nature01772

H. W. Tedford and G. W. Zamponi, Direct G Protein Modulation of Cav2 Calcium Channels, Pharmacological Reviews, vol.58, issue.4, pp.837-862, 2006.
DOI : 10.1124/pr.58.4.11

A. M. Van-den-maagdenberg, J. Haan, G. M. Terwindt, and M. Ferrari, Migraine: gene mutations and functional consequences, Current Opinion in Neurology, vol.20, issue.3, pp.299-305, 2007.
DOI : 10.1097/WCO.0b013e3281338d1f