GLP-1, the gut-brain, and brain-periphery axes.

Abstract : Glucagon-like peptide 1 (GLP-1) is a gut hormone which directly binds to the GLP-1 receptor located at the surface of the pancreatic β-cells to enhance glucose-induced insulin secretion. In addition to its pancreatic effects, GLP-1 can induce metabolic actions by interacting with its receptors expressed on nerve cells in the gut and the brain. GLP-1 can also be considered as a neuropeptide synthesized by neuronal cells in the brain stem that release the peptide directly into the hypothalamus. In this environment, GLP-1 is assumed to control numerous metabolic and cardiovascular functions such as insulin secretion, glucose production and utilization, and arterial blood flow. However, the exact roles of these two locations in the regulation of glucose homeostasis are not well understood. In this review, we highlight the latest experimental data supporting the role of the gut-brain and brain-periphery axes in the control of glucose homeostasis. We also focus our attention on the relevance of β-cell and brain cell targeting by gut GLP-1 for the regulation of glucose homeostasis. In addition to its action on β-cells, we find that understanding the physiological role of GLP-1 will help to develop GLP-1-based therapies to control glycemia in type 2 diabetes by triggering the gut-brain axis or the brain directly. This pleiotropic action of GLP-1 is an important concept that may help to explain the observation that, during their treatment, type 2 diabetic patients can be identified as 'responders' and 'non-responders'.
Type de document :
Article dans une revue
Review of Diabetic Studies, The Society for Biomedical, 2011, 8 (3), pp.418-31. 〈10.1900/RDS.2011.8.418〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00756731
Contributeur : Marie Francoise Simon <>
Soumis le : vendredi 23 novembre 2012 - 16:05:59
Dernière modification le : lundi 26 novembre 2012 - 14:27:22

Lien texte intégral

Identifiants

Collections

Citation

Cendrine Cabou, Rémy Burcelin. GLP-1, the gut-brain, and brain-periphery axes.. Review of Diabetic Studies, The Society for Biomedical, 2011, 8 (3), pp.418-31. 〈10.1900/RDS.2011.8.418〉. 〈inserm-00756731〉

Partager

Métriques

Consultations de la notice

69