G. Watt and P. Parola, Scrub typhus and tropical rickettsioses, Current Opinion in Infectious Diseases, vol.16, issue.5, pp.429-465, 2003.
DOI : 10.1097/00001432-200310000-00009

S. Seong, M. Choi, and I. Kim, Orientia tsutsugamushi infection:overview and immune responses, Microbes and Infection, vol.3, issue.1, pp.11-21, 2001.
DOI : 10.1016/S1286-4579(00)01352-6

S. Chattopadhyay and A. Richards, Scrub Typhus Vaccines: Past History and Recent Developments, Human Vaccines, vol.3, issue.3, pp.73-80, 2007.
DOI : 10.4161/hv.3.3.4009

A. Tamura, N. Ohashi, H. Urakami, and S. Miyamura, Classification of Rickettsia tsutsugamushi in a New Genus, Orientia gen. nov., as Orientia tsutsugamushi comb. nov., International Journal of Systematic Bacteriology, vol.45, issue.3, pp.589-91, 1995.
DOI : 10.1099/00207713-45-3-589

N. Cho, H. Kim, J. Lee, S. Kim, J. Kim et al., The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host cell interaction genes, Proceedings of the National Academy of Sciences, vol.104, issue.19, pp.7981-7987, 2007.
DOI : 10.1073/pnas.0611553104

D. Paris, R. Phetsouvanh, A. Tanganuchitcharnchai, M. Jones, K. Jenjaroen et al., Orientia tsutsugamushi in Human Scrub Typhus Eschars Shows Tropism for Dendritic Cells and Monocytes Rather than Endothelium, PLoS Neglected Tropical Diseases, vol.1166, issue.1, p.1466, 2012.
DOI : 10.1371/journal.pntd.0001466.s003

M. De-fost, W. Chierakul, K. Pimda, A. Dondorp, and N. White, Van der Poll. T Activation of cytotoxic lymphocytes in patients with scrub typhus, Am J Trop Med Hyg, vol.72, pp.465-472, 2005.

S. Kramme, A. L. , V. Khoa, N. Trin-le, V. Tannich et al., Orientia tsutsugamushi Bacteremia and Cytokine Levels in Vietnamese Scrub Typhus Patients, Journal of Clinical Microbiology, vol.47, issue.3, pp.586-595, 2009.
DOI : 10.1128/JCM.00997-08

J. Yun, Y. Koh, K. Lee, J. Hyun, Y. Choi et al., Infection, Microbiology and Immunology, vol.36, issue.6, pp.551-558, 2005.
DOI : 10.1111/j.1348-0421.2005.tb03761.x
URL : https://hal.archives-ouvertes.fr/hal-00830742

M. Benoit, E. Ghigo, C. Capo, D. Raoult, and J. Mege, The Uptake of Apoptotic Cells Drives Coxiella burnetii Replication and Macrophage Polarization: A Model for Q Fever Endocarditis, PLoS Pathogens, vol.285, issue.5
DOI : 10.1371/journal.ppat.1000066.s005

G. Dennis, B. Sherman, D. Hosack, Y. J. Gao, W. Lane et al., DAVID: database for annotation, visualization, and integrated discovery, Genome Biology, vol.4, issue.5, p.3, 2003.
DOI : 10.1186/gb-2003-4-5-p3

F. Martinez, S. Gordon, M. Locati, and A. Mantovani, Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression, The Journal of Immunology, vol.177, issue.10, pp.7303-7314, 2006.
DOI : 10.4049/jimmunol.177.10.7303

D. Mosser and J. Edwards, Exploring the full spectrum of macrophage activation, Nature Reviews Immunology, vol.117, issue.12, pp.958-69, 2008.
DOI : 10.1038/nri2448

M. Benoit, B. Desnues, and J. Mege, Macrophage Polarization in Bacterial Infections, The Journal of Immunology, vol.181, issue.6, pp.3733-3742, 2008.
DOI : 10.4049/jimmunol.181.6.3733

A. Untergasser, H. Nijveen, X. Rao, T. Bisseling, R. Geurts et al., Primer3Plus, an enhanced web interface to Primer3, Nucleic Acids Research, vol.35, issue.Web Server, pp.71-75, 2007.
DOI : 10.1093/nar/gkm306

B. Tseng, H. Yang, J. Liou, L. Chen, and Y. Hsu, Immunohistochemical Study of Scrub Typhus: A Report of Two Cases, The Kaohsiung Journal of Medical Sciences, vol.24, issue.2, pp.92-100, 2008.
DOI : 10.1016/S1607-551X(08)70103-7

T. Byrd and M. Horwitz, Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron., Journal of Clinical Investigation, vol.83, issue.5, pp.1457-65, 1989.
DOI : 10.1172/JCI114038

H. Chu, J. Lee, S. Han, S. Kim, N. Cho et al., Exploitation of the Endocytic Pathway by Orientia tsutsugamushi in Nonprofessional Phagocytes, Infection and Immunity, vol.74, issue.7, pp.4246-53, 2006.
DOI : 10.1128/IAI.01620-05

Y. Rikihisa and S. Ito, Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes, Journal of Experimental Medicine, vol.150, issue.3, pp.703-711, 1979.
DOI : 10.1084/jem.150.3.703

D. Levy, I. Marie, and J. Durbin, Induction and function of type I and III interferon in response to viral infection, Current Opinion in Virology, vol.1, issue.6, pp.476-86, 2011.
DOI : 10.1016/j.coviro.2011.11.001

A. Moussawi, K. Ghigo, E. Kalinke, U. Alexopoulou, L. Mege et al., Type I Interferon Induction Is Detrimental during Infection with the Whipple's Disease Bacterium, Tropheryma whipplei, PLoS Pathogens, vol.75, issue.1, p.1000722, 2010.
DOI : 10.1371/journal.ppat.1000722.s003

A. Lebreton, P. Cossart, and H. Bierne, Bacteria tune interferon responses by playing with chromatin, Virulence, vol.181, issue.1, pp.87-91, 2012.
DOI : 10.1074/jbc.M110.207068
URL : https://hal.archives-ouvertes.fr/hal-01350803

T. Decker, M. Muller, and S. Stockinger, The Yin and Yang of type I interferon activity in bacterial infection, Nature Reviews Immunology, vol.264, issue.9, pp.675-87, 2005.
DOI : 10.1016/j.it.2004.08.010

A. Billings, H. Feng, J. Olano, and D. Walker, Rickettsial infection in murine models activates an early anti-rickettsial effect mediated by NK cells and associated with production of gamma interferon, Am J Trop Med Hyg, vol.65, pp.52-58, 2001.

D. Walker, J. Olano, and H. Feng, Critical Role of Cytotoxic T Lymphocytes in Immune Clearance of Rickettsial Infection, Infection and Immunity, vol.69, issue.3, pp.1841-1847, 2001.
DOI : 10.1128/IAI.69.3.1841-1846.2001

J. Carrero, B. Calderon, and E. Unanue, Infection, The Journal of Experimental Medicine, vol.137, issue.4, pp.535-575, 2004.
DOI : 10.1038/nature01850

K. Mayer-barber, B. Andrade, D. Barber, S. Hieny, C. Feng et al., Innate and Adaptive Interferons Suppress IL-1?? and IL-1?? Production by Distinct Pulmonary Myeloid Subsets during Mycobacterium tuberculosis Infection, Immunity, vol.35, issue.6, pp.1023-1057, 2011.
DOI : 10.1016/j.immuni.2011.12.002
URL : http://doi.org/10.1016/j.immuni.2011.12.002

S. Mariathasan and D. Monack, Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation, Nature Reviews Immunology, vol.96, issue.1, pp.31-40, 2007.
DOI : 10.1038/nri1997

M. Kim, M. Kim, and J. Kang, Orientia tsutsugamushi inhibits tumor necrosis factor ?? production by inducing interleukin 10 secretion in murine macrophages, Microbial Pathogenesis, vol.40, issue.1, pp.1-7, 2006.
DOI : 10.1016/j.micpath.2005.09.002

U. Boehm, T. Klamp, M. Groot, and J. Howard, Cellular responses to interferon-gamma