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Immunomodulatory and antitumour effects of abnormal Savda Munziq on S180 tumour-bearing mice.
Aikemu A., Umar A., Yusup A., Upur H., Berké B., Bégaud B., Moore N.
BMC Complementary and Alternative Medicine 12, 1 (2012) 157 - http://www.hal.inserm.fr/inserm-00748704
 (22978453) 
Immunomodulatory and antitumour effects of abnormal Savda Munziq on S180 tumour-bearing mice.
Ainiwaer Aikemu1, 2, Anwar Umar3, 4, Abdiryim Yusup3, Halmurat Upur () 2, 3, Bénédicte Berké3, 4, Bernard Bégaud3, 4, Nicholas Moore () 3, 4
1 :  Department of Drug Analysis
Xinjiang Medical University
830011, Urumqi, Xinjiang
Chine
2 :  Faculty of Traditional Uyghur Medicine
Xingjiang Medical University
830011, Urumqi, Xingjiang
Chine
3 :  Department of Pharmacology
Xinjiang Medical University
830011, Urumqi, Xingjiang
Chine
4 :  Laboratoire de Pharmacologie Expérimentale
Université Victor Segalen - Bordeaux II – CHU Bordeaux – Département Hospitalo-Universitaire de Pharmacologie de Bordeaux
Zone Nord - Bâtiment 1A - Case 36 - 146, rue Léo Saignat 33076 Bordeaux Cedex
France
UNLABELLED: ABSTRACT: BACKGROUND: Abnormal Savda Munziq (ASMq), a traditional uyghur medicine, has shown anti-tumour properties in vitro. This study attempts to confirm these effects in vivo and measure effects on the immune system. METHODS: Kunming mice transplanted with Sarcoma 180 cells were treated with ASMq (2-8 g/kg/day) by intra-gastric administration compared to model and cyclophosphamide (20 mg/kg/day). After the 14th day post tumour implant, thymus, liver, spleen and tumours were removed, weighed, and processed for histopathological analysis. Blood samples were also taken for haematological and biochemical analyses including TNF-α , IL-1 β and IL-2. Splenic lymphocyte function was measured with MTT; lymphocyte subpopulations were measured by flow cytometry. RESULTS: ASMq treated animals had reduced tumour volume compared to model and increased concentrations of TNF-α, IL-1β and IL-2 compared to untreated and to cyclophosphamide-treated animals. No histopathological alterations were observed. The absence of viable S180 cells and the presence of necrotic cells and granulation tissue were observed in tumour tissue of treated animals. The effect on T lymphocytes was unclear. CONCLUSIONS: ASMq confirmed in vivo anti-tumour effects observed in vitro, which may be at least in part mediated by increased immune activity.
Sciences du Vivant/Pharmacologie/Médicaments/Pharmacologie
Sciences du Vivant/Pharmacologie/Médicaments
Anglais
1472-6882

Articles dans des revues avec comité de lecture
10.1186/1472-6882-12-157
BMC Complementary and Alternative Medicine (BMC Complement Altern Med)
Publisher BioMed Central
ISSN 1472-6882 
internationale
2012
17/09/2012
12
1
157

This research work was supported by Ministry of Education Changjiang Scholar and Innovative Team Development Program of China No.IRT0977 This research work was supported by National Natural Science Foundation of China (No.30260128).
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