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Smoking Status and Metabolic Syndrome in the Multi-Ethnic Study of Atherosclerosis. A cross-sectional study.
Berlin I., Lin S., Lima J. Ac, Bertoni A. Gerald
Tobacco Induced Diseases 10, 1 (2012) 9 - http://www.hal.inserm.fr/inserm-00748513
Smoking Status and Metabolic Syndrome in the Multi-Ethnic Study of Atherosclerosis. A cross-sectional study.
Ivan Berlin () 1, Susan Lin2, Joao Lima3, Alain Bertoni4
1 :  CPN - Centre de Psychiatrie et Neurosciences
Université Paris V - Paris Descartes – Université Pierre et Marie Curie (UPMC) - Paris VI – INSERM : U894
2 ter Rue d'Alésia - 75014 PARIS
2 :  CFCM - Center for Family and Community Medicine
Columbia University Medical Center
630 West 168th Street - P&S Box 100 - New York, NY 10032
3 :  Cardiovascular Imaging
The Johns Hopkins Hospital – Johns Hopkins University School of Medicine – Heart and Vascular Institute
600 N. Wolfe Street - Sheikh Zayed Tower - Blalock Room 524 - Baltimore, MD 21287
4 :  Department of Epidemiology & Prevention
Wake Forest University Health Sciences – Public Health Siences (PHS)
Division of Public Health Sciences - Medical Center Boulevard, Winston-Salem, North Carolina 27157-1063
ABSTRACT: BACKGROUND: Current smoking is associated with type 2 diabetes mellitus and impaired glucose tolerance but its association with the metabolic syndrome (metS), particularly with sufficiently sampled African American representation, has not been clearly established. OBJECTIVE: To assess whether a) metS is associated with smoking; b) any increased risk of metS among smokers is independent of body mass index (BMI) compared with non-smokers; c) smoking status is differentially associated with the metS and its components across different ethnic groups. METHODS: Cross sectional analysis of the Multi-Ethnic Study of Atherosclerosis (MESA) a community population-based sample free of cardiovascular disease. RESULTS: Current smokers (N=769) had higher risk of metS (odds ratio [OR, 95 % confidence interval]: 1.4, 1.1-1.7) versus never (reference, N=2981) and former smokers (1.0, 0.8-1.1, N=2163) and for metS components: high waist circumference (WC) (OR:1.9, 1.2-2.1), low high density lipoprotein cholesterol (HDL-C) (1.5, 1.3-1.8), elevated plasma triglycerides (TG) (OR:1.4, 1.2-1.7) as well as high C-reactive protein (CRP, an inflammatory marker) concentration (OR: 1.6,1.3-2.0) compared to never and former smokers after adjustment for BMI. A smoking status by ethnicity interaction occurred such that African American current and former smokers had greater likelihood of low HDL-C than White counterparts. CONCLUSIONS: This study found that smoking is associated with the metS and despite the lower BMI of current smokers the prevalence of low HDL-C, elevated TG and CRP is higher among them than among non-smokers. African American individuals generally have higher HDL-C than Whites but smoking wipes out this advantage.
Sciences du Vivant/Santé publique et épidémiologie

Articles dans des revues avec comité de lecture
Tobacco Induced Diseases
Publisher BioMed Central
ISSN 1617-9625 

Metabolic syndrome – Smoking – Ethnic groups – Body mass index
The MESA study was supported by contracts N01-HC-95159 through N01-HC-95169 from the National Heart, Lung and Blood Institute
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