PMID: identifiant
de la référence Pubmed : |
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 (18336639) |
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| titre : |
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The -308 TNFalpha gene polymorphism in severe acute alcoholic hepatitis: identification of a new susceptibility marker. |
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| auteur(s) : |
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Eric Nguyen-Khac1, 2, Hakim Houchi2, Martine Daoust2, Jean Louis Dupas1, Mickaël Naassila2 |
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| laboratoire : |
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| résumé : |
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BACKGROUND: This study investigated whether genetic polymorphisms in the tumor necrosis factor alpha (TNFalpha) gene's promoter region play a role in severe acute alcoholic hepatitis (AAH). METHODS: One-hundred and fifty patients (58 AAH patients, 45 cirrhosis group free-AAH, 47 healthy group) were genotyped for 3 TNFalpha polymorphisms (-238, -308, -863) using a polymerase chain reaction-restriction fragment length polymorphism technique. Serum TNFalpha levels were determined. RESULTS: The TNFalpha-308 allele A frequency was significantly lower in AAH group (0.09), than cirrhosis (0.28) (p < 0.001), and healthy groups (p < 0.001). The TNFalpha-308 A/G, A/A genotypes were significantly lower in AAH group, than cirrhosis (p = 0.005), and healthy groups (p < 0.001). For AAH group, there were no clinical, biological, and serum TNFalpha differences between the -308 G/G and A/G, A/A genotype patients, apart higher transaminase in the former group (p = 0.02). AAH and cirrhosis groups did not differ for the frequency of TNFalpha-238, -863 polymorphisms. The specific genotype did not appear to have any influence on the therapeutic response following corticotherapy or posttreatment 6-month survival. In the AAH group, nonsurvivors had higher TNFalpha levels than survivors (7.9 +/- 8.8 vs. 3.3 +/- 1.6 pg/ml, p = 0.01). CONCLUSIONS: These results attest to the involvement of TNFalpha-related genetic factors in susceptibility to AAH. |
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| domaine : |
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Sciences du Vivant/Neurosciences
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langue du texte
intégral : |
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Anglais |
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| ISSN : |
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0145-6008 |
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| type de publication : |
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Articles dans des revues avec comité de lecture |
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| DOI : |
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10.1111/j.1530-0277.2008.00629.x |
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| journal : |
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| Alcoholism: Clinical and Experimental Research (Alcohol Clin Exp Res) |
| Publisher |
Wiley-Blackwell |
| ISSN |
0145-6008 (eISSN : 1530-0277) |
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| Audience : |
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internationale |
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| date de publication : |
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05/2008 |
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date de publication
électronique : |
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11/03/2008 |
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| volume : |
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32 |
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| numéro : |
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5 |
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| page, identifiant, ... : |
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822-8 |
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| Descripteur(s) MeSH : |
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Adrenal Cortex Hormones – Adult – Aged – Female – Genetic Predisposition to Disease – Genotype – Hepatitis – Alcoholic – Humans – Liver Cirrhosis – Male – Middle Aged – Polymorphism – Single Nucleotide – Promoter Regions – Genetic – Tumor Necrosis Factor-alpha |
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