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Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure.
Barbier E., Pierrefiche O., Vaudry D., Vaudry H., Daoust M., Naassila M.
Neuropharmacology 55, 7 (2008) 1199-211 - http://www.hal.inserm.fr/inserm-00746171
Long-term alterations in vulnerability to addiction to drugs of abuse and in brain gene expression after early life ethanol exposure.
Estelle Barbier1, Olivier Pierrefiche1, David Vaudry2, Hubert Vaudry2, Martine Daoust1, Mickaël Naassila1
1 :  Alcoolisation précoce et vulnerabilité à la dépendance
INSERM : ERI24 – Université de Picardie Jules Verne
faculte de pharmacie 1, rue des louvels 80037 AMIENS CEDEX 1
2 :  Neuroendocrinologie cellulaire et moléculaire
INSERM : IFR23 – Université de Rouen
Universite de Rouen 76821 MONT-SAINT-AIGNAN CEDEX
Exposure to ethanol early in life can have long-lasting implications on brain function and drug of abuse response later in life. The present study investigated in rats, the long-term consequences of pre- and postnatal (early life) ethanol exposure on drug consumption/reward and the molecular targets potentially associated with these behavioral alterations. Since a relationship has been demonstrated between heightened drugs intake and susceptibility to drugs-induced locomotor activity/sensitization, anxiolysis, we tested these behavioral responses, depending on the drug, in control and early life ethanol-exposed animals. Our results show that progeny exposed to early life ethanol displayed increased consumption of ethanol solutions and increased sensitivity to cocaine rewarding effects assessed in the conditioned place preference test. Offspring exposed to ethanol were more sensitive to the anxiolytic effect of ethanol and the increased sensitivity could, at least in part, explain the alteration in the consumption of ethanol for its anxiolytic effects. In addition, the sensitivity to hypothermic effects of ethanol and ethanol metabolism were not altered by early life ethanol exposure. The sensitization to cocaine (20 mg/kg) and to amphetamine (1.2 mg/kg) was increased after early life ethanol exposure and, could partly explain, an increase in the rewarding properties of psychostimulants. Gene expression analysis revealed that expression of a large number of genes was altered in brain regions involved in the reinforcing effects of drugs of abuse. Dopaminergic receptors and transporter binding sites were also down-regulated in the striatum of ethanol-exposed offspring. Such long-term neurochemical alterations in transmitter systems and in the behavioral responses to ethanol and other drugs of abuse may confer an increased liability for addiction in exposed offspring.
Sciences du Vivant/Neurosciences

Articles dans des revues avec comité de lecture
Neuropharmacology (Neuropharmacology)
Publisher Elsevier
ISSN 0028-3908 

Amphetamine – Animals – Anxiety – Avoidance Learning – Brain Chemistry – Central Nervous System Depressants – Central Nervous System Stimulants – Choice Behavior – Cocaine – Conditioning – Operant – Ethanol – Female – Gene Expression – Male – Motor Activity – Polymorphism – Genetic – Pregnancy – Radioligand Assay – Rats – Sprague-Dawley – Receptor – Cannabinoid – CB1 – Receptors – Dopamine D1 – Dopamine D2 – GABA-A – N-Methyl-D-Aspartate – Reverse Transcriptase Polymerase Chain Reaction – Substance-Related Disorders