Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.

Pascal Legendre 1, * Benjamin Förstera 2, 3 Rene Jüttner 4 Jochen Meier 3
* Auteur correspondant
1 Physiopathologie des Maladies du Système Nerveux Central
2 Fachbereich Biologie, Chemie & Pharmazie
3 RNA Editing and Hyperexcitability Disorders
4 Developmental Neurobiology
Abstract : Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged due to the discovery of posttranscriptional processing. GLR transcripts are edited through enzymatic modification of a single nucleotide leading to amino acid substitution within the neurotransmitter binding domain. RNA editing produces gain-of-function receptors well suited for generation and maintenance of tonic inhibition of neuronal excitability. As neuronal activity deprivation in early stages of development or in epileptic tissue is detrimental to neurons and because RNA editing of GlyR is up-regulated in temporal lobe epilepsy patients with a severe course of disease a pathophysiological role of these receptors emerges. This review contains a state-of-the-art discussion of (patho)physiological implications of GlyR RNA editing.
keyword : RNA editing RNA splicing hippocampus epilepsy GABA
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Article dans une revue
Frontiers in Molecular Neuroscience, Frontiers Media, 2009, 2, pp.23. <10.3389/neuro.02.023.2009>
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Pascal Legendre, Benjamin Förstera, Rene Jüttner, Jochen Meier. Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.. Frontiers in Molecular Neuroscience, Frontiers Media, 2009, 2, pp.23. <10.3389/neuro.02.023.2009>. <inserm-00745356>

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