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Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.
Legendre P., Förstera B., Jüttner R., Meier J. C.
Front Mol Neurosci 2 (2009) 23 - http://www.hal.inserm.fr/inserm-00745356
 (19936314) 
Glycine Receptors Caught between Genome and Proteome - Functional Implications of RNA Editing and Splicing.
Pascal Legendre () 1, Benjamin Förstera2, 3, Rene Jüttner4, Jochen Meier3
1 :  Physiopathologie des Maladies du Système Nerveux Central
INSERM : U952 – Université Pierre et Marie Curie (UPMC) - Paris VI – CNRS : UMR7224
Bât. B, 4ème étage, case courrier 37 9 quai Saint Bernard 75252 Paris Cedex 05
France
2 :  Fachbereich Biologie, Chemie & Pharmazie
Freie Universität Berlin
Kaiserswerther Straße 16-18 14195 Berlin
Allemagne
3 :  RNA Editing and Hyperexcitability Disorders
Max Delbrück Center for Molecular Medicine
Robert-Rössle-Straße 13125 Berlin
Allemagne
4 :  Developmental Neurobiology
Max Delbrück Center for Molecular Medicine
Robert-Rössle-Straße 13125 Berlin
Allemagne
Information processing in the brain requires a delicate balance between excitation and inhibition. Glycine receptors (GlyR) are involved in inhibitory mechanisms mainly at a synaptic level, but potential novel roles for these receptors recently emerged due to the discovery of posttranscriptional processing. GLR transcripts are edited through enzymatic modification of a single nucleotide leading to amino acid substitution within the neurotransmitter binding domain. RNA editing produces gain-of-function receptors well suited for generation and maintenance of tonic inhibition of neuronal excitability. As neuronal activity deprivation in early stages of development or in epileptic tissue is detrimental to neurons and because RNA editing of GlyR is up-regulated in temporal lobe epilepsy patients with a severe course of disease a pathophysiological role of these receptors emerges. This review contains a state-of-the-art discussion of (patho)physiological implications of GlyR RNA editing.
Sciences du Vivant/Génétique
Anglais
1662-5099

Articles dans des revues avec comité de lecture
10.3389/neuro.02.023.2009
Front Mol Neurosci
internationale
2009
09/11/2009
2
23

RNA editing – RNA splicing – hippocampus – epilepsy – GABA
This study was supported by the DFG (ME2075/3-1 to JCM and RA424/5-1 to RJ, and Sonderforschungsbereich SFB-TR3 B5 to Jochen C. Meier) and the Helmholtz Association (VH-NG-246 to Jochen C. Meier), and Institut National de la Santé Et de la Recherche Médicale (INSERM to Pascal Legendre), and Centre de la Recherché Scientifique (CNRS to Pascal Legendre).
Acronyme NEURO
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