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Plasma and exhaled breath condensate nitrite-nitrate level in relation to environmental exposures in adults in the EGEA study.
Rava M., Varraso R., Decoster B., Huyvaert H., Le Moual N., Jacquemin B., Künzli N., Kauffmann F., Zerimech F., Matran R. et al
Nitric Oxide: Biology and Chemistry 27, 3 (2012) 169-75 - http://www.hal.inserm.fr/inserm-00742527
(22750238)
Plasma and exhaled breath condensate nitrite-nitrate level in relation to environmental exposures in adults in the EGEA study.
Marta Rava () 1, Raphäelle Varraso1, Brigitte Decoster2, Hélène Huyvaert2, Nicole Le Moual1, Bénédicte Jacquemin1, Nino Künzli3, 4, Francine Kauffmann1, Farid Zerimech5, Régis Matran2, Rachel Nadif1
1 :  CESP - Centre de recherche en épidémiologie et santé des populations
INSERM : U1018 – Université Paris XI - Paris Sud – Hôpital Paul Brousse – Assistance publique - Hôpitaux de Paris (AP-HP)
16 avenue Paul Vaillant Couturier 94807 Villejuif Cedex, France
France
2 :  Service de Physiologie
PRES Université Lille Nord de France : EA4483
Faculté de Médecine - 1 Rue du Professeur Calmette 59000 Lille
France
3 :  University Basel Medical School
University Basel Medical School
Klingelbergstrasse 61, CH-4056 Basel
Suisse
4 :  Epidemiology & Public Health
SwissTropical and Public Health Institute – Medical School University of Basel
Socinstrasse 57, P.O.Box 4002, Basel
Suisse
5 :  Service de Biochimie
CHRU Lille
Boulevard du Professeur Leclercq 59037 Lille
France
This study evaluated the associations between biological markers in the nitrate-nitrite-NO pathway and four environmental exposures among subjects examined in the second survey (2003-2007) of the French Epidemiological study on Genetics and Environment of Asthma (EGEA). Total nitrite and nitrate (NO(2)(-) /NO(3)(-)) levels were measured both in plasma and in exhaled breath condensate (EBC) in 949 adults. Smoking, diet and exposure to chlorine products were assessed using standardized questionnaires. Exposure to air pollutants was estimated by using geostatistical models. All estimates were obtained with generalized estimating equations for linear regression models. Median levels of NO(2)(-)/NO(3)(-) were 36.3μM (1st-3rd quartile: 25.7, 51.1) in plasma and 2.0μmol/mg proteins (1st-3rd quartile 0.9, 3.9) in EBC. After adjustment for asthma, age, sex and menopausal status, plasma NO(2)(-)/NO(3)(-) level increased with leafy vegetable consumption (above versus below median=0.04 (95%CI: 0.001, 0.07)) and decreased in smokers (versus non/ex-smokers=-0.08 (95%CI: -0.11, -0.04). EBC NO(2)(-)/NO(3)(-) level decreased in smokers (-0.08 (95%CI: -0.16, -0.001)) and with exposure to ambient O(3) concentration (above versus below median=-0.10 (95%CI: -0.17, -0.03)). Cured meat, chlorine products, PM(10) and NO(2) concentrations were not associated with NO(2)(-)/NO(3)(-) levels. Results suggest that potential modifiable environmental and behavioral risk factors may modify NO(2)(-)/NO(3)(-) levels in plasma and EBC according to the route of exposure.
Sciences du Vivant/Santé publique et épidémiologie
Anglais
1089-8603

Articles dans des revues avec comité de lecture
10.1016/j.niox.2012.06.007
Nitric Oxide: Biology and Chemistry (Nitric Oxide)
Publisher Elsevier
ISSN 1089-8603 (eISSN : 1089-8611)
internationale
15/10/2012
27/06/2012
27
3
169-75

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